Jiayan Nie's research while affiliated with Hubei Biopesticide Engineering Research Centre and other places

Publications (6)

Article
Hypoxia, the most common feature in the tumor microenvironment, is closely related to tumor malignant progression and poor patient’s prognosis. Exosomes, initially recognized as cellular “garbage dumpsters”, are now known to be important mediums for mediating cellular communication in tumor microenvironment. However, the mechanisms of hypoxic tumor...
Article
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Background and AimsHypoxia represents one of the most pervasive microenvironmental stresses in HCC due to the overwhelming growth and inadequate blood supply. HIF1α as an important transcription factor participates in the regulation of various biological behaviors of HCC cells under hypoxia. Our previous study indicated that miR-375 is a hypoxia-as...
Article
Full-text available
Background: Consumption of ultra-processed foods (UPFs) plays a potential role in the development of obesity and other diet-related noncommunicable diseases (NCDs), but no studies have systematically focused on this. This study aimed to summarize the evidence for the association between UPFs consumption and health outcomes. Methods: A comprehens...
Article
Full-text available
Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and inflammation, and its influence on CD4+ T cell activation, proliferation, and differentiation of inflammatory bowel disease (IBD). Methods: LncRNA expression profiles were detecte...
Article
Background: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. We aimed to clarify the characteristics and clinical significance of peripheral lymphocyte subset alteration in COVID-19. Methods: The levels of peripheral lymphocyte subsets were measured by flow...

Citations

... These exosomes contain high levels of miRNA-210-3p, which inhibit apoptosis and promote the transition from G1 to S cycle by downregulating the expression of CELF2. Clinical investigation has also revealed that exosomes containing miRNA-210-3p have high levels in colorectal cancer patients and are correlated with an unfavorable prognosis [98]. Therefore, the signaling networks affected by exosomes may determine tumor progression by influencing TME [99,100]. ...
... Many ready-to-eat or ready-to-heat foods and drinks are high in added sugars, sodium, saturated fats, and refined carbohydrates. Excessive consumption of these nutrients and ultra-processed foods increases the risk of obesity and related NCDs [13][14][15][16][17][18][19][20][21][22][23][24][25]. Indeed, a growing literature including both a large randomized controlled trial and over 45 longitudinal cohort studies linked ultra-processed food with increased risk of overweight/obesity, diet-related NCDs, and total and heart disease-linked mortality [16,26]. ...
... While the impact of NSAIDs (non-steroidal anti-inflammatory drugs) and oral contraceptives [256,257], whose long-term consumption is known to be associated with IBD, on the epigenome of IBD patients has apparently not yet been investigated, other molecules have a known impact (Table 4). Several treatments used in IBD exert their anti-inflammatory action via epigenetic modifications, such as 5ASA [258,259], anti-TNF [125,127,[260][261][262][263][264], exclusive enteral nutrition [265] and mesenchymal stem cells [266,267]. Antibiotics [268][269][270] and probiotics [271][272][273][274][275][276] can also reduce gut inflammation through various epigenetic mechanisms. ...
... The results of this study have showed that there was no significant difference in the short-term mortality between the two groups, but there was a reduced inflammatory response in patients who received parenteral glutamine supplementation to enteral nutrition, especially at the 7 th day NLR, 4 th and 7 th day PLR. The increased and unregulated synthesis of soluble inflammatory markers known as "cytokine storm" is a common cause of acute respiratory distress syndrome (ARDS) in COVID-19 patients [11,12]. ARDS, which is defined by immune cell infiltration in both the lungs and hypoxemia, is the primary cause of death in COVID-19. ...
... Changing the cell cycle mechanism of tumors is an important means to maintain its unlimited proliferation ability and also an important cause of tumor growth and increase of tumor load in vivo. In addition, clinical deaths that are associated with liver cancer are also caused by metastatic lesions (26). Therefore, the occurrence and development of tumors are often inhibited to prolong the survival time of patients with advanced liver cancer by inhibiting cell proliferation, inducing cell apoptosis, affecting the tumor cell cycle, and weakening the invasion and metastasis ability of liver cancer (27). ...
... Huang et al analyzed the rst 41 cases with COVID-19, and found that compared with non-ICU patients, ICU patients had higher plasma levels of cytokines, which could be associated with disease severity [7] . Chen et al analyzed 21 cases with COVID- 19, and found that compared with moderate cases, severe cases had markedly higher levels of cytokines, and markedly lower numbers of T lymphocytes, CD4 + T cells, and CD8 + T cells [8] . Ulhaq et al also presented the evidence that circulating IL-6 levels are closely linked to the severity of COVID-19 [9] . ...