Jiang-Nan Wu's research while affiliated with Fudan University and other places

... The active hormone, 1alpha,25-dihydrocholecalciferol [1,25(OH)2D3], is often considered only in terms of its role in controlling calcium and phosphorus homeostasis (1,2). Apart from this, VitD is also involved in immune regulation, nerve transmission, and cell differentiation, and has been linked to the prevention and treatment of multiple diseases (1)(2)(3)(4). The Chinese dietary guidelines (2022 edition) recommend that pregnant women should aim for 10-20 min of sunlight exposure per day, on average; pregnant women living in high latitude areas, experiencing sunlight deficiency during winter, or having insufficient outdoor activities to synthesize VitD through sunlight should consider taking VitD supplements, with a dosage of 10 μg/day (400 IU/day) (5). ...

... 35 However, the role of IL-27 in PE remains controversial. While Jahantigh found a positive correlation between elevated IL-27 levels and PE severity, 9 Yin's research showed no notable contrast in serum IL-27 levels between the control and PE groups but noticed a surge in the expression of IL-27 and its receptors in trophoblast cells in PE. 36 Additionally, Zhang found that IL-27 can encourage the proliferation, migration, and invasion of trophoblast cells, 37 while Ge found that IL-27 regulates the epithelial-mesenchymal transition of trophoblast cells, thereby inhibiting their migratory and invasive capacity, and contributing to the pathogenesis of PE. 38 These discrepancies could be due to differences in sample size, time of onset of PE, and IL-27 concentrations applied in in vitro experiments. The role of IL-27 as a pleiotropic cytokine in pregnancy complications requires further exploration. ...

... The GSE146904 dataset contains 10 lumbar degenerated disc (DH and DS; n = 5 for each tissue) specimens identifying the regulatory pathway for patients undergoing lumbar discectomy (Bydon et al. 2020). For GSE146904, we calculated the average expression values for the same gene with multiple probe sets (Lai et al. 2023). The raw count was then filtered with genes expressed in at least 75% of the samples, normalized, and DEGs were selected using the edgeR Bioconductor program (Robinson et al. 2010). ...

... However, there are still some barriers in improving the coverage and effectiveness of hepatitis B vaccination, such as a delay of the hepatitis B vaccine first dose, the impact of substitutable vaccine, immune failure, and cost of maternal antiviral treatment. [16][17][18][19]20,21,22,23 In addition, the decline in hepatitis B awareness is one of the challenges for the prevention and control of HBV infection in China. 16,24 In the present study, we identified that hepatitis B awareness has declined since the inclusion of hepatitis B into the national immunization program in 1992. ...

... However, when the highly prevalent T118A variant was excluded from the analysis, the prevalence of immune-escape variants remained stable over the years in this region as well (Table 2). When all the regional data were collated together, the overall prevalence of immune-escape HBsAg variants was 25 Since comparable ratios between HBV-A and HBV-D genotypes and, respectively, between ad and ay serotypes were observed only in Yakutia, we were only able to analyze the differences in the prevalence of immune-escape variants between HBV genotypes for this study region. The prevalence was significantly higher in HBV-D sequences compared to HBV-A sequences (p = 0.0008, Fisher's exact test) in the sequence set from 2018-2022, but not in the sequences collected prior to 2010. ...

... Given that the sensitive and vulnerable early period of foetal development is between the 3 rd and the 8 th weeks of gestation [5] and that a sustained period (e.g. 12 weeks) of FA is required to achieve an effective redblood-cell (RBC) folate level for attenuating the risk of NTDs [10,11], the guideline recommended starting FA 3 months before conception or initiating supplementation immediately after pregnancy [9]. However, as most pregnant women in China have their first prenatal care visit after the 7 th week of gestation [12], this may delay the initiation of FA. Inappropriate FA supplementation may reduce the effectiveness of prevention (e.g. ...

... In contrast, Aslan et al. reported higher serum apelin levels in pregnant women with GDM than in healthy pregnant women (155). Also, a recent meta-analysis showed that GDM is associated with increased apelin levels (156). Moreover, Boucher et al. found increased apelin levels at the beginning of pregnancy in obese women and mice (157). ...

... LIGHT is expressed in lymphoid tissues and can bind to three receptors: herpesvirus entry mediator (HVEM), lymphotoxin β receptor (LTβR), and DcR3 [33,34]. The primary effects of LIGHT-LTβR activation include induction of apoptosis and, in most cases, the LIGHT-HVEM interaction also selectively activates NF-κB, which initiates inflammationassociated gene transcription [35]. ...

... The secondary outcome was the risk of varying degrees of PTB (moderately and late PTB, very PTB, and extremely PTB). The relevant variables were as follows: maternal age (<20, [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], and >40 years), sex (male and female), maternal body mass index (BMI) before pregnancy (underweight, normal, overweight, and obese), marital status (married and unmarried), mother's race [White, Black, American Indian/Alaskan Native (AIAN), Asian, Native Hawaiian or Other Pacific Islander (NHOPI), and more than 1 race], parental education attainment (< high school, high school, associate degree, and ≥ bachelor's degree), prenatal care starting time (1st to 3rd month, 4th to 6th month, 7th to final month, and no prenatal care), smoking (no smoking, smoking before pregnancy, and smoking during pregnancy), history of PTB and cesareans, hypertensive eclampsia, infertility and its treatment [no treatment, fertility-enhancing drugs, assisted reproductive technology (ART), and other treatments], diabetes (prepregnancy diabetes, gestational diabetes, and no diabetes), hypertension (pre-pregnancy hypertension, gestational hypertension, and no hypertension), live birth order, mother's nativity (born in the US, born outside the US, and unknown), gonorrhea, syphilis, chlamydia, hepatitis B, and hepatitis C. ...

... The brand used for the booster dose can be similar to (homologous booster) or different from (heterologous booster) previous doses [13]. Both booster regimens are well-known and effective [14][15][16]. ...