Jian Hu's research while affiliated with Harbin Medical University and other places
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Publications (9)
Background:
Bipolar disorder (BD) and alcohol use disorder (AUD) are two major independent causes of psychopathology in the general population. The prevalence of AUD in BD is high. Identifying the clinical and demographic features of patients with BD who may develop AUD could help with early identification and intervention.
Methods:
Data from 23...
Aims:
To study whether autophagy participates in the neuroprotective effect of nerve growth factor (NGF) on neurons treated with alcohol.
Methods:
The autophagy-related markers were used to explore the role of autophagy in PC12 cells exposed to alcohol or pre-incubated with NGF before initiating the treatment with alcohol (100 mM; 6 h). PC12 cel...
The purpose of this study was to investigate the association between the metabotropic glutamate receptor 3 (GRM3) subunit gene and alcohol dependence by the single-nucleotide polymorphisms (SNPs). Methods: Two hundred and forty-eight male alcohol-dependent patients and 235 male control subjects were recruited. Ten SNPs in the GRM3 region were studi...
Primer sequences for PCR-LDR of GRM3 region.
Background:
We studied the effects of single nucleotide polymorphisms (SNPs) in the metabotropic glutamate receptor 3 (GRM3) gene on brain N-acetylaspartate (NAA) concentrations and executive function (EF) skills in non-smoking, active alcoholics, and evaluated associations between these variables.
Methods:
SNPs (rs6465084, rs1468412, and rs2299...
The human serotonin receptor 1B (HRT1B) plays an important role in regulating serotonin release. Previous research has suggested that the genetic variation of the HTR1B gene may confer susceptibility to alcoholism or some subtypes of alcohol dependence, but the evidence has been inconsistent. The aim of the present study is to examine whether polym...
The aims of this study were (a) to investigate the neuropathological damage in brain regions and changes of corticosteroid concentrations related to chronic alcohol administration, (b) to see what effect fluoxetine (Prozac) has on the neuropathological damage and corticosteroid levels, and (c) to evaluate the potential association between neuropath...
This study examined the association of plasma homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with schizophrenia in the Han population residing in northern China. We detected the MTHFR C677T genotype in 123 schizophrenia patients and compared it with the genotype of 123 controls by polymerase chain reaction...
Citations
... In line with recently published data [47], we observed that hearts from DOXO-treated mice have reduced NGF content, already in the initial phases of treatment, which is expected to compromise the ability of CMs to feed innervating neurons. Such mechanisms, previously not taken into account, may overlap the neurotoxic effects of DOXO, including the induction of oxidative stress and autophagy impairment, given that NGF, in addition to activating pro-survival and trophic signaling [84][85][86][87], has antioxidant effects and is an autophagy activator in both CMs and SNs [88][89][90][91]. ...
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... Выявлена взаимосвязь в зависимости от полиморфизма генов между уровнем серотонина в головном мозге и алкогольной зависимостью на материале исследовательской выборки китайских ханьцевпредставителей преобладающей национальности в провинции Хэйлунцзян. По результатам генетических исследований обнаружено, что полиморфизм гена 5-HTR1B, гена DRD2, гена TaqIA и метаботропного глутаматного рецептора 3 (GRM3) связан с предрасположением к развитию алкогольной зависимости в китайской популяции ханьцев, что можно расценивать как новую мишень, на которую должно быть направлено внимание при лечении алкоголизма [1,2]. ...
... Subcortical GM. Altered levels of NAA were noted within the cerebellum (combined VOIs from cerebellar cortex [56,57,59,62,63], vermis [47,54,55,57,61,64], and dentate nucleus [57]) and the hippocampus [65,66]. Both models indicated lower NAA levels within the alcohol-using group (Cerebellum: k = 12; g = −0.36; ...
... In 1998 the first association between a polymorphism in this gene and alcohol addiction was identified, but this association was also produced in the simultaneous presence of antisocial behaviour and the results were relatively unreliable [19,25,26]. Positive associations have also been observed between this gene and alcohol dependence in the Taiwanese Han and Chinese populations [27,28], although some studies have been unable to replicate these results [29]. In the case of cocaine addiction, the only notable study is that carried out by Cigler et al. (2001), which, similar to a study on methamphetamine addiction carried out in a Japanese population [30], did not detect any association. ...
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... Патофизиологические исследования показывают снижение числа нейронов в мозге лабораторных крыс на фоне воздействия алкоголя. Инновационное лечение стволовыми клетками, очень популярное в последние 10 лет, показало, что мезенхимальные стволовые клетки могут ингибировать хроническое вызванное этанолом окислительное повреждение у крыс [3,4]. ...
... There are a lot of similar studies [39,40]. On the other hand, studies have found that elevated homocysteine levels and the TT genotype of the methylenetetrahydrofolate reductase (MTFHR) gene, which leads to elevated homocysteine levels, are associated with the risk of schizophrenia [27,41]. At the same time, some studies have found that the homocysteine level of brothers and sisters of patients with schizophrenia is significantly higher than that of the general population [28]. ...
