Ji-Su Kim's research while affiliated with Incheon National University and other places
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Publications (117)
Background: Nanodiamonds have gained a rapidly growing interest in biomedical applications; however, little is known regarding their biokinetics owing to difficulties in measurements and limited synthesis/purification technologies. In this study, we investigated the distribution kinetics of detonation-synthesized nanodiamonds in mice via intravenou...
Microplastics (MPs) are found in every ocean and are frequently ingested by marine animals. This study analyzed MPs in the stomachs and intestines of 12 large marine animals comprising one fin whale (Balaenoptera physalus), seven finless porpoises (Neophocaena asiaeorientalis), two loggerhead turtles (Caretta caretta), one Indo-Pacific bottlenose d...
Through a literature survey and meta-data analysis, monitoring methods and contamination levels of marine micro- and macroplastics in seawater were compared between the North Pacific and the world's other ocean basins. The minimum cut-off size in sampling and/or analysis of microplastics was crucial to the comparison of monitoring data. The North P...
Cytokine release syndrome (CRS) is a systemic inflammatory response resulting in overexpression of cytokines in serum and tissues, which leads to multiple-organ failure. Due to rapid aggravation of symptoms, timely intervention is paramount; however, current therapies are limited in their capacity to address CRS. Here, we find that the intravenous...
Polypropylene (PP) is the second most highly produced plastic worldwide, and its microplastic forms are found in water and food matrices. However, the effects of PP microplastics on human health remain largely unknown. Here, we prepared 85.2 µm-sized weathered PP (w-PP) microplastics by sieving the microplastic particles after fragmentation and acc...
Arctic sea ice entraps microplastics (MP) from seawater and atmosphere and is recognized as sink and transport vector of MPs. However, ice-trapped fraction in the global MP budget, contribution of atmospheric input, and linkage among Arctic basins remain unclear. To assess them, we investigated the number- and mass-based data separated by size and...
The presence of microplastics in the various food web raised concerns on human health, but little is known about the target cells and mechanism of toxicity of microplastics. In this study, we evaluated the toxicity of microplastics using relevant cell lines to the oral route of exposure. Approximately 100 μm-sized fragment-type polypropylene (PP) a...
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered potential candidates for alleviating this disorder. Pinoresinol, a lignan found in Forsythia suspensa, is a memory-enhancing agen...
Despite intensive use of plastics in agriculture, little is known about the occurrence of microplastics (MPs) in agro-environment. To identify the effect of internal sources and environmental fate on MP appearance in farmland, we examined four soil types with different agricultural practices representing either direct application of polyethylene (P...
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mechanisms involved in Aβ pathology, much remains unknown. Previous findings suggested that a protein regulated in d...
Increasing concern of human exposure to microplastics (MPs) necessitates an assessment of the quality of MP data relevant to human exposure. In this literature review for table salt, we addressed the variability and uncertainty of MP data caused by different analytical methods among studies. Additionally, validation experiment was conducted to iden...
Background:
The BLOC1S2 gene encodes the multifunctional protein BLOS2, a shared subunit of two lysosomal trafficking complexes: i) biogenesis of lysosome-related organelles complex-1 and i) BLOC-1-related complex. In our previous study, we identified an intriguing unreported transcript of the BLOC1S2 gene that has a novel exon derived from two tr...
Progranulin (PGRN) is a cysteine-rich secreted protein expressed in endothelial cells, immune cells, neurons, and adipocytes. It was first identified for its growth factor-like properties, being implicated in tissue remodeling, development, inflammation, and protein homeostasis. However, these findings are controversial, and the role of PGRN in liv...
BACKGROUND/AIM:
Peroxiredoxin (Prx) V has been known as an antioxidant enzyme which scavenges intracellular reactive oxygen species (ROS). Also, Prx V has been shown to mediate cell apoptosis in various cancers. However, the mechanism of Prx V-induced apoptosis in colon cancer cells remains unknown. Thus, in this study we analyzed the effects of...
Infrastructure in animal husbandry refers to fundamental facilities and services necessary for better living conditions of animals and its economy to function through better productivity. Mainly, infrastructure can be divided into two categories: hard infrastructure and soft infrastructure. Physical infrastructure, such as buildings, roads, and wat...
Background/Aim: Peroxiredoxin (Prx) protein family is aberrantly expressed in various cancers including gastric cancer. Among the six family members, Prx V has been known as an antioxidant enzyme which scavenges intracellular reactive oxygen species (ROS) and modulates cellular apoptosis. This study aimed at investigating the role of Prx V in apopt...
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis, steatohepatitis, chronic hepatitis with liver fibrosis or cirrhosis, and hepatocellular carcinoma. However, the mechanisms behind the pathogenesis of alcoholic liver disease ar...
BACKGROUND/AIM:
Staphylococcus aureus (S. aureus) is a major gram-positive pathogen, which can cause toxic and immunogenic injuries both in nosocomial and community-acquired infections. Peroxiredoxin (Prx) I plays crucial roles in cellular apoptosis, proliferation, and signal transduction as well as in immunoregulation. The present study aimed to...
Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer (PC). Despite their usefulness, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer...
This study proposes two collection network design models that determine the locations and capacities of collection centres and the allocations of refuse at demand points to the opened collection centres: a single-period static model for time-invariant demands and a multi-period restricted-dynamic model for time-variant demands over a planning horiz...
Previous studies have identified microplastics (MPs) in commercial table salts but could not exactly address the origin of the MPs because of several limitations. The present study is based on the hypothesis that commercial sea salts can act as an indicator of MP pollution in the surrounding environment unless the MPs are filtered out during the ma...
Pig-human xenotransplantation can trigger cell-mediated immune responses. We explored the role of gangliosides in inflammation related to immune rejection in xenotransplantation. Co-culture of xenogeneic cells (pig-MSCs and RAW264.7) was used to emulate xenotransplantation conditions. MTT assay results indicated that cell viability was significantl...
Tyrosinase is a copper-containing enzyme that regulates melanin biosynthesis and is encoded by the tyrosinase (TYR) gene. Previous studies demonstrated that mutations in TYR could lead to oculocutaneous albinism type 1 (OCA1) owing to the failure of melanin formation. Although a previous study found that albinism in the rhesus monkey was derived fr...
Glycosphingolipids are important components of the outer layer of the plasma membrane in the majority of eukaryotic cells. Specifically, gangliosides are sialic acid‑containing glycosphingolipids that participate in cell‑cell recognition, adhesion, proliferation, differentiation and signal transduction, and are integral components of cell surface m...
The current study was performed to investigate the effect of oocyte donor status, including age and body weight, on metaphase II (MII) oocyte recovery using two superovulation methods in cynomolgus monkeys. The use of Method A [recombinant gonadotrophin (75 IU/kg, 3×, 3-day intervals) and human chorionic gonadotropin (hCG)] led to great increases i...
This study addresses a variant of job-shop scheduling in which jobs are grouped into job families, but they are processed individually. The problem can be found in various industrial systems, especially in reprocessing shops of remanufacturing systems. If the reprocessing shop is a job-shop type and has the component-matching requirements, it can b...
Psoriasis is a chronic inflammatory immune-mediated autoimmune skin disorder. The histamine H4 receptor (H4R) agonist 4-methylhistamine (4-MH) plays an important role in immunomodulation of inflammatory responses associated with allergic inflammatory diseases. In this study, we investigated the effects of H4R agonist 4-MH on the development of imiq...
TSEN54 encodes a subunit of the tRNA-splicing endonuclease complex, which catalyzes the identification and cleavage of introns from precursor tRNAs. Previously, we identified an AluSx -derived alternative transcript in TSEN54 of cynomolgus monkey. Reverse transcription-polymerase chain reaction (RT-PCR) amplification and TSEN54 sequence analysis of...
Supplementary Figure S1. Verification of no genomic DNA contamination in various cDNA samples. Supplementary Figure S2. Putative translational sequence of alternative transcripts of TSEN54. Supplementary Figure S3. Multiple alignment analysis of human and primate MER54, AluYl17, and AluSx sequences in TSEN54. Supplementary Figure S4. PCR and multip...
ZKSCAN5 (also known as ZFP95) is a zinc-finger protein belonging to the Krűppel family. ZKSCAN5 contains a SCAN box and a KRAB A domain and is proposed to play a distinct role during spermatogenesis. In humans, alternatively spliced ZKSCAN5 transcripts with different 5'-untranslated regions (UTRs) have been identified. However, investigation of our...
BCS1L gene encodes mitochondrial protein and is a member of conserved AAA protein family. This gene is involved in the incorporation of Rieske FeS and Qcr10p into complex III of respiratory chain. In our previous study, AluYRa2-derived alternative transcript in rhesus monkey genome was identified. However, this transcript has not been reported in h...
In line with recent findings showing Alzheimer's disease (AD) as an insulin-resistant brain state, a non-transgenic animal model with intracerebroventricular streptozotocin (icv-STZ) administration has been proposed as a representative experimental model of AD. Although icv-STZ rodent models of AD have been increasingly researched, studies in non-h...
The accumulation and aggregation of misfolded proteins in the brain, such as amyloid-β (Aβ) and hyperphosphorylated tau, is a neuropathological hallmark of Alzheimer's disease (AD). Previously, we developed and validated a novel non-human primate model for sporadic AD (sAD) research using intracerebroventricular administration of streptozotocin (ic...
This paper reports a case study on designing and operating a Korean municipal refuse collection system. Refuse collection, one of indispensable activities in reverse logistics, is the activity that gathers end-of-use/life products and moves them to the facilities where further recovery or disposal is done. The case problem consists of two sub-probl...
Despite of the application of numerous supplements to improve in vitro culture (IVC) of mammalian cells, few studies have been conducted concerning the effect of fetal bovine serum (FBS) on early development of mammalian embryos. Thus, the current study was carried out to determine the effect of FBS on the developmental competence of porcine embryo...
Activators of protein kinase A (PKA) signaling pathway have been frequently used to transiently stall meiosis at early phase of in vitro maturation (IVM) for balancing between cytoplasmic and nuclear maturation of mammalian embryos. Despite of the tight association of 6-diazo-5-oxo-l-norleucine (DON), an inhibitor of hyaluronan synthesis, with PKA...
Although the beneficial roles of HDAC inhibitors (HDACis) in somatic cell nuclear transfer (SCNT) were known, few studies have conducted concerning the role of valproic acid (VPA) as an efficient HDACi for SCNT and its associated developmental event(s). Thus, the present study was carried out to determine the effect of VPA on developmental competen...
The coupling of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress has been explored using a variety of biological systems, but little is known regarding their role in the early development of mammalian embryos. Here, we demonstrated that early embryonic development of in vitro-produced (IVP) bovine embryos was governed by the coop...
Gangliosides are ubiquitous components of cell membranes that can act as mediators of cell adhesion and signal transduction. However, their interaction with adhesion molecules in vascular grafts following xenotransplantation is not yet clearly understood. In this study, human umbilical vein endothelial cells (HUVECs) were cocultured with porcine ao...
The coupling of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress has been explored extensively, but little is known regarding their role in the early development of mammalian embryos. Here, we demonstrated that the early development of in vitro-produced (IVP) bovine embryos was governed by the cooperative action between ROS and E...
This study considers network design, capacity planning and vehicle routing for collection systems in reverse logistics. The network design and capacity planning problems are to determine the static locations and capacities of collection points as well as the dynamic allocations of demand points to the opened collection points over a planning horizo...
This study considers the problem of determining the locations of collection points as well as the allocations of refuses at demand points to collection points while satisfying the capacity and the maximum allowable collection distance constraints at each collection point. To consider fluctuating demands commonly occurred in refuse collection system...
Refuse collection network design, one of major decision problems in reverse logistics, is the problem of locating collection points and allocating refuses at demand points to the opened collection points. As an extension of the previous models, we consider capacity and maximum allowable distance constraints at each collection point. In particular,...
This paper considers the problem of determining operation and maintenance schedules for a containership equipped with various subsystems during its sailing according to a pre-determined navigation schedule. The operation schedule, which specifies working time of each subsystem, determines the due-date of each maintenance activity and the maintenanc...
We reported previously that the intracerebroventricular streptozotocin (icv-STZ)-treated cynomolgus monkey showed regionally specific glucose hypometabolism in FDG-PET imaging, similar to that observed in the early stages of sporadic Alzheimer's disease (sAD). However, further pathological analyses of this model at the molecular level are needed to...
While a critical role of autophagy in mammalian early embryogenesis has been demonstrated, few studies have been conducted regarding the role of autophagy in in vitro maturation (IVM) of immature oocytes. In the present study we investigated the effect of rapamycin, a chemical autophagy inducer, on the nuclear and cytoplasmic maturation of porcine...
We consider the input sequencing and scheduling problems in a reconfigurable manufacturing system, a state-of-the-art manufacturing system designed at the outset for rapid changes in its hardware and software components. Due to the inherent operation and routing flexibilities of the system, each part is processed according to a multiple process pla...
This paper considers the job shop scheduling problem with alternative operations and machines, called the flexible job shop scheduling problem. As an extension of previous studies, operation and routing flexibilities are considered at the same time in the form of multiple process plans, i.e. each job can be processed through alternative operations,...
In the investigation of the expression levels of target genes, reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the most accurate and widely used method. However, a normalization step is a prerequisite to obtain accurate quantification results from RT-qPCR data. Therefore, many studies regarding the selection of r...
Nucleotide sequences of the candidate reference genes from the cynomolgus monkey.
(DOCX)
Despite the positive roles of histone deacetylase inhibitors in somatic cell nuclear transfer (SCNT), few studies have evaluated valproic acid (VPA) and its associated developmental events. Thus, the present study was conducted to elucidate the effect of VPA on the early development of bovine SCNT embryos and the underlying mechanisms of action. Th...
Many methods for efficient production of transgenic animals for biomedical research have been developed. Despite great improvements in transgenesis rates resulting from the use of intracytoplasmic sperm injection (ICSI), the ICSI-based sperm-mediated gene-transfer (iSMGT) technique is still not optimal in terms of sperm permeabilization efficiency...
Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) has been widely used to quantify relative gene expression because of the specificity, sensitivity, and accuracy of this technique. In order to obtain reliable gene expression data from RT-qPCR experiments, it is important to utilize optimal reference genes for the norm...
Melting curve analyses of the candidate reference genes and target genes in the total samples.
(TIF)
Nucleotide sequences of the candidate reference genes and target genes from the cynomolgus monkey brain.
(TIF)
Gangliosides are ubiquitous components of the membranes of mammalian cells that are thought to play important roles in various cell functions such as cell-cell interaction, cell adhesion, cell differentiation, growth control, and signaling. However, the role that gangliosides play in the immune rejection response after xenotransplantation is not ye...
Gangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs...
This study considers common due-date assignment and scheduling on parallel machines. The problem has three decision variables: assigning the common-due-date, allocating jobs to parallel machines, and sequencing the jobs assigned to each machine. The objective is to minimise the sum of due-date assignment, earliness and tardiness penalties. A mathem...
This paper presents a novel similarity measure that computes similarity scores among scientific research papers. The text of a given paper in online scientific literature is often found to be incomplete in terms of its potential to be compared with others, which likely leads to inaccurate results. Our solution to this problem makes use of both text...
In this paper, we report a case study on the common due-date assignment and scheduling problem in a paper remanufacturing system that produces corrugated cardboards using collected waste papers for a given set of orders under the make-to-order (MTO) environment. Since the system produces corrugated cardboards in an integrated process and has sequen...
Background
As a human replacement, the crab-eating macaque (Macaca fascicularis) is an invaluable non-human primate model for biomedical research, but the lack of genetic information on this primate has represented a significant obstacle for its broader use.
Results
Here, we sequenced the transcriptome of 16 tissues originated from two individuals...
Figure S1. Flowchart for bioinformatic analysis. Figure S2. Length distribution of crab-eating macaque isotigs. For the analysis of length distribution, clustered and unclustered isotigs were analyzed. Figure S3. Manual selection method for TE-derived AS events.
The coupling of autophagy and endoplasmic reticulum (ER) stress has been implicated in a variety of biological processes; however, little is known regarding the involvement of the autophagy/ER stress pathway in early embryogenesis or the underlying mechanism(s). Here, we showed that the developmental competence of in vitro-produced (IVP) bovine emb...
Gangliosides play an important role in neuronal differentiation processes. The regulation of ganglioside levels is related to the induction of neuronal cell differentiation. In this study, the ST8Sia5 gene was transfected into mESCs and then differentiated into neuronal cells. Interestingly, ST8Sia5 gene transfected mESCs expressed GQ1b by HPTLC an...
The accelerated cooling rate associated with vitrification reduces injuries attributed to cryopreservation and improves the post-freezing developmental competence of vitrified embryos. In this study, embryos were vitrified and warmed and morphologically evaluated for their development to blastocysts. Survival rates between the fresh (96.7%±3.8%) an...
