Jessica Iovine's research while affiliated with University of California, Los Angeles and other places

... Nilotinib is approved by the FDA for treatment of chronic myeloid leukemia, but has failed to demonstrate benefit in phase 2 trials in PD, PDD, and AD [11]. Bosutinib, another tyrosine kinase inhibitor approved for chronic myeloid leukemia, was associated with less worsening in CDR-SB and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) performance in an open label study with 15 AD and 16 PDD patients after 1 year of treatment [18]. A phase 2 clinical trial was recently completed in DLB showing adequate safety and tolerability, reduction of CSF a-synuclein and dopamine catabolism, and functional improvement in activities of daily living [19]. ...

... As different types of childhood trauma are associated with alternative psychopathologies and divergent tendencies towards antisocial outcomes (e.g., relapse and rearrest), it is imperative to understand the neurobiological correlates that may be promoting these patterns (Curran et al., 2018;Dalsklev et al., 2019;Hyman et al., 2008). Likewise, being able to establish the relationship between specific childhood traumas and regional abnormal brain activity may have additional translational value in region-specific non-invasive brain stimulation interventions meant to ease the symptoms related to trauma-induced psychopathologies (Blades et al., 2020;Hu et al., 2021). Here we report the use of the Trauma Checklist (TCL) 2.0-an assessment scored using multiple data sources (including institutional files, self-report and clinical assessments, and clinical videotaped interviews)-and principal component analysis (PCA) to test the effects of summed childhood trauma (in the case of novel cumulative effects of trauma) and specific subtypes of childhood trauma exposure (including types of community and observed trauma) on resting-state functional connectivity in a sample of 179 incarcerated juvenile males. ...

... Two studies were reported regarding the use of A2M for peripheral nerves. A study by Jordan and colleagues was done for chronic pain in chronic regional pain syndrome (CRPS)/fibromyalgia, thoracic outlet syndrome, and musculotendinous pain [7]. The study showed a favorable response when injected into brachial plexus targets in patients with thoracic outlet syndrome as compared with those diagnosed with CRPS/fibromyalgia [7]. ...

... Most methods of VCID treatments involve temporarily disrupting the tight junctions at the BBB (e.g., via focused ultrasound or drugs for phosphorylation of tight junctions) to deliver drugs to the brain [5][6][7]. However, this approach has the potential to treat the effects of VCID but not the primary cause. ...

... As such, tFUS may be an appropriate tool to target this region. Indeed, some work has been done, targeting this region in conjunction with exosomes to treat refractory depression [69]. So, while both TMS and tFUS are used to modulate nodes of functional circuits, TMS is more suited for modulation of cortical nodes, while tFUS is better suited for modulation of sub-cortical nodes. ...