Jérôme Yelnik's research while affiliated with French National Centre for Scientific Research and other places

Publications (116)

Chapter
Recently, different organizational levels of the striatopallidal and pallidothalamic projections have been studied through various experimental approaches. This has brought to light important characteristics of this major part of the basal ganglia system. For example it has been shown that the medial pallidum receives a specific and significant inp...
Article
The morphology and distribution of dopaminergic interplexiform cells in adult rat and monkey retinas were analyzed to determine any correlation with the function of dopamine in the outer retinal layers. The retinas were processed as whole mounts for tyrosine hydroxylase immunohistochemistry. There was a network formed by the sclerally directed proc...
Article
Neuronal morphology was analyzed in the central complex (centre median-parafascicular complex) of macaques and humans. Cell bodies were described from Nissl material. Golgi-impregnated dendritic arborizations were reconstructed from serial sections and digitized in three dimensions by computer-assisted microscopy. The central complex was subdivided...
Chapter
In the first IBAGS book we tried to define the basal ganglia and to determine their components using rational criteria. Eight years later, an answer, acceptable by most specialists, may be given. It now appears advisable to place the set of the basal ganglia in a more general system also including their inputs and outputs. Despite numerous attempts...
Chapter
The existence of a compartmentation of the striatum suggests that this neuronal set consists of different subdivisions, namely the striosomes and matrix (Graybiel and Ragsdale, 1978), which could process separately different types of information. Characteristically, this occurs in tight neuronal set-spaces (see Percheron et al. in this volume) whic...
Article
A quantitative taxonomy of primate striatal neurons was elaborated on the basis of the morphology of Golgi-impregnated neurons. Dendritic arborizations were reconstructed from serial sections and digitized in three dimensions by means of a video computer system. Topological, metrical, and geometrical parameters were measured for each neuron. Groups...
Chapter
Since the discovery of intrinsic retinal dopamine (DA)-neurons (Malmfors, 1963), a number of physiological roles in retinal neurotransmission have been established for DA (see Ehinger, 1983, for review). The best documented at the level of cellular and molecular biology is unquestionably the uncoupling action of DA on horizontal cell gap junctions...
Article
The spatial organization of Golgi-stained dendritic arborizations of the substantia nigra was studied in three dimensions by using a video computer system. Dendritic orientation was analyzed in relation to the cytoarchitectonic boundaries and to the direction of the axons of the striato-pallidonigral bundle. All the brains, humans and macaques, wer...
Article
Neuronal morphology was analyzed in the pars compacta, reticulata, and lateralis of the substantia nigra of humans and macaques. Golgi-impregnated dendritic arborizations, reconstructed from serial sections, were described by using topological, metrical, and geometrical parameters measured in three dimensions. Morphological parameters were statisti...
Chapter
Human pathology or experimental lesions easily disclose which “modality” of nervous activity sensory or motor pyramidal systems are dealing with. This is not the case in basal ganglia (see DeLong and Georgopoulos, 1981). Many recent studies look for the identification of substances involved in synaptic transmission. Our approach is purely morpholog...
Article
The most widely used conventional stereotactic method utilizing the Horsley-Clarke coordinate system does not allow accurate intracerebral placements. Improving the precision of stereotactic surgery in monkeys has become imperative in neurological research to limit the waste of animals. This problem can be resolved with the use of a stereotactic te...
Article
An atlas of the macaque substantia nigra was established in ventricular coordinates. Having verified that nigral contours are stable in both Macaca mulatta and Macaca speciosa, the antero-posterior sequence of four subdivisions was described on eight vertico-transverse levels after a comparison between histological and histochemical data. The pars...
Article
The morphology of pallidal neurons was analyzed quantitatively in Golgi-impregnated brains of men and macaques (Macaca irus). Selected neurons were drawn with a camera lucida and reconstructed from serial sections. Dendritic arborizations were analyzed in three dimensions using a video computer microscope (Yelnik et al., 1981). Morphological (topol...
Article
An atlas of transverse sections of the globus pallidus and striatum was established in macaque with reference to ventricular coordinates. The three-dimensional geometry of the striato-pallidal complex was investigated by means of sagittal and horizontal reconstructions. Both a personal case studied with autoradiography and data from literature were...

Citations

... Studies reported five cases of postoperative ICH (~1.6%), of which one resulted in prolonged finger palsy 29 and another resulted in prolonged dysarthria. 53 Finally, in two cases (0.8%), DBS therapy itself became the source of a new obsession (eg, checking settings and battery life), which contributed to worsening OCD. 40 47 For a ...
... She manifested progressive walking difficulties with freezing of gait and had to use a walking aid. Increasing gait abnormalities were initially thought to be related to long-term effects of neurostimulation 13 ; dopaminergic denervation was subsequently discovered on DaTscan, and she was treated with levodopa (600 mg/day) with partial gait improvement. At last examination (61 years old; Hôpital Pitié-Salpêtrière, Paris, France), she presented generalized dystonia with signs of parkinsonism, including rightsided akinesia, right-foot freezing and festination, along with dysarthria and hypophonia (Supporting Information Video 2). ...
... Frequency and width of spontaneous spikes generated by CA1 pyramidal neurons that contributed to calcium influx through the L-type voltagedependent calcium channels increased. Senova et al, 20 2019 ...
... The blood releases oxygen to active neurons faster than inactive neurons, which causes changes in the relative levels of oxyhemoglobin and deoxyhemoglobin, can be detected by MRI-blood oxygenation level dependent (MRI-BOLD) sequences based on their different magnetic susceptibility [177]. In a study of the subcortical GM of TBI patients, TBI subjects were noticed to have a significant reduction in CVR in subcortical GM regions compared to HCs [178]. In addition, CVR of TBI patients was found to significantly decrease in multiple temporal lobe gyri bilaterally as well [179]. ...
... These devices exhibit numerous advantages in improving the quality of patient life and/or extending patient life, although supplying power to these devices is still a technical challenge. Deep brain stimulation (DBS) as a powerful tool has been clinically used to treat Parkinson's disease (4), essential tremor (5), dystonia (6), pain (7), and other diseases (8)(9)(10). However, its power supply remains a main challenge (11)(12)(13)(14)(15)(16)(17), as shown in fig. ...
... 49,119,120 Interestingly, a recent study found that DBS of the GPi was able to induce MDD, indicating a possible role for the globus pallidus in the neurocircuitry underlying MDD. 121 Indeed, previous investigation of the development of MDD after subcortical brain lesions found that 89% of patients that developed MDD had lesions of the GPe. 122 Further research is needed to fully elucidate the roles of the NAc, STN, and GP in MDD and GAD and their efficacy as therapeutic targets. ...
... In this study, individual anatomical variability was partially accounted for by translation of pathways to the patientspecific space using a subcortical normalization strategy . Nevertheless, the proposed method of optimal activation profile derivation could be applied for basal ganglia pathways directly reconstructed from patient data as described in Pujol et al. (2017). ...
... In the literature, changes in depression, anxiety and impulse-control disorders following DBS for PD are mixed (some indicate overall improvements within samples, others declines) [29], and these divergent outcomes were reflected in the clinicians' comments. Instances of increased irritability [30] and transient episodes of mania [31] and hypomania [32] described by our sample of clinicians working in OCD, have also been reported in OCD DBS literature. The nature and prevalence of personality change differed substantially according to treatment indications (e.g. ...
... 15 However, in a report by Fleury and colleagues, which was also conducted with a target in the brain, contrary results were seen and gait deteriorated in participants with DBS. 16 The occurrence of FOG was also demonstrated in other studies after DBS was used in patients without PD suffering from other movement disorders, such as generalized dystonia. 17,18 One could assume that these differences in the effect of DBS on the occurrence or severity of FOG may correlate with the patients' response to dopaminergic drugs; 19 however, it appears that the stimulation parameters and configuration including voltage, frequency, and electrode location also play an important role and that some options may have more beneficial effects in improving FOG. ...
... Selected studies were seven case series observational studies [24][25][26][27][29][30][31], one randomized crossover trial [28], and twelve individual case reports [32][33][34][35][36][37][38][39][40][41][42][43]. Genotype of the patients with the indication of number of CAG triplets was available in all studies, with the exception of four [37][38][39]41]. ...