# Jeong Hee Hong's research while affiliated with University of Southern Denmark and other places

## Publications (154)

Preprint
We construct an action of the Thompson group F on a compact space built from pairs of infinite, binary rooted trees. The action arises as an F-equivariant compactification of the action of F by translations on one of its homogeneous spaces, F/H_2, corresponding to a certain subgroup H_2 of F. The representation of F on the Hilbert space l^2(F/H_2)...
Preprint
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Lysosomes are responsible for protein degradation and clearance in cellular recycling centers. It has been known that the lysosomal chloride level is enriched and involved in intrinsic lysosomal function. However, the mechanism by which chloride levels can be sensed and the chloride-mediated lysosomal function is unknown. In this study, we verified...
Article
We apply a method inspired by Popa's intertwining-by-bimodules technique to investigate inner conjugacy of MASAs in graph $C^*$ -algebras. First, we give a new proof of non-inner conjugacy of the diagonal MASA ${\mathcal {D}}_E$ to its non-trivial image under a quasi-free automorphism, where $E$ is a finite transitive graph. Changing graphs represe...
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The biomarker 8-hydroxy-2′-deoxyguanosine (oh8dG) is derived from oxidized nucleic acids or products of oxidant-mediated DNA damage. Enhanced sodium bicarbonate cotransporter (NBC) activity is caused by reactive oxygen species (ROS) production in ventricular myocytes. Thus, we hypothesized that cardioplegia-solution-mediated ROS generation may be i...
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Lamins are nuclear envelope proteins involved in various cellular functions, such as DNA modulation, cellular differentiation, and development. In this study, we investigate the role of histamine in lung cancer biology. Since it is known that lamin-A/C is negatively regulated in lung cancer, we hypothesize that histamine signaling is related to nuc...
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The ubiquitin–proteasome system (UPS) is the main proteolytic pathway by which damaged target proteins are degraded after ubiquitination and the recruit of ubiquitinated proteins, thus regulating diverse physiological functions and the maintenance in various tissues and cells. Ca2+ signaling is raised by oxidative or ER stress. Although the basic f...
Article
s Estrogen therapy has used to prevent bone loss in postmenopausal women. Although therapeutically enhanced estrogen levels have been suggested, patients are exposed to greater risks of nephrolithiasis and cancer. It has been known that oxalate or bicarbonate transporter SLC26A6 is involved in oxalate homeostasis and its deletion results in kidney...
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by aggressive fibroblast-like synoviocytes (FLSs) and pannus formation. Various therapeutic strategies have been developed against inflammatory cytokines in RA in recent decades. Based on the migratory features of FLSs, we examined whether modulation of the migratory module attenuates...
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The canonical roles of chloride channels and chloride-associated transporters have been physiologically determined; these roles include the maintenance of membrane potential, pH balance, and volume regulation and subsequent cellular functions such as autophagy and cellular proliferative processes. However, chloride channels/transporters also play o...
Preprint
We apply a method inspired by Popa's intertwining-by-bimodules technique to investigate inner conjugacy of MASAs in graph $C^*$-algebras. First we give a new proof of non-inner conjugacy of the diagonal MASA ${\mathcal D}_E$ to its non-trivial image under a quasi-free automorphism, where $E$ is a finite transitive graph. Then we exhibit a large cla...
Article
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Cardiac surgeries have been improved by accompanying developing cardioplegia solutions. However, the cardioplegia application presents an ongoing challenge with a view of a sufficiently restored cardiac function. In this review, we focus on the cardioplegia-induced mechanism and summarize the findings of studies undertaken to improve cardioprotecti...
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Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation of the synovial membrane ultimately leading to permanent damage in the affected joints. For this study, synovial fluids from 16 patients diagnosed with either RA or osteoarthritis (OA) were used to examine volume regulation and cooperative water channels, both of which are...
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The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2...
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix-degrading enzymes in RA. Approaches that induce various cellular growth alterations of synoviocytes...
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Metastatic features of breast cancer in the brain are considered a common pathology in female patients with late-stage breast cancer. Ca2+ signaling and the overexpression pattern of Ca2+ channels have been regarded as oncogenic markers of breast cancer. In other words, breast tumor development can be mediated by inhibiting Ca2+ channels. Although...
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Although cardiac tissue is considered a target of gravitational force (g-force), the mechanism of hypergravity on the ion modulation or identification of ion transporters is still unknown. Thus, we determine the effect of hypergravity on a physical force-sensitive cytokine, IL-6 and its related channel activity to investigate rat cardiac function c...
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Spinophilin (SPL) is a multifunctional actin-binding scaffolding protein. Although increased research on SPL in cancer biology has revealed a tumor suppressive role, its modulation in cancer biology, and oncological relevance remains elusive. Thus, we determined the role of SPL in the modulation of the junctional network and cellular migration in A...
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Keratinocyte migration is initiated toward the wound skin barrier as a crucial process in wound healing. However, the migratory machinery used by keratinocytes is relatively unknown. Histamine signaling, including an increase in the Ca2+ signal, mediated the enhanced protein expression and chloride/bicarbonate exchange activity of anion exchanger A...
Article
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IP3 receptor-binding protein released with IP3 (IRBIT) interacts with various ion channels and transporters. An electroneutral type of sodium bicarbonate cotransporter, NBCn1, participates in cell migration, and its enhanced expression is related to cancer metastasis. The effect of IRBIT on NBCn1 and its relation to cancer cell migration remain obs...
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Background Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell type-specific transcriptomic changes...
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The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeti...
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Particulate matter (PM) is a type of air pollutant that induces adverse health effects, including acute exacerbation of chronic obstructive pulmonary disease (COPD). However, the effects of co-exposure to PM and cigarette smoke extract (CSE) on bronchial epithelial cells remain unknown. This study investigated the cytotoxic and pro-inflammatory eff...
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Applications of nanoparticles in various fields have been addressed. Nanomaterials serve as carriers for transporting conventional drugs or proteins through lysosomes to various cellular targets. The basic function of lysosomes is to trigger degradation of proteins and lipids. Understanding of lysosomal functions is essential for enhancing the effi...
Preprint
The problem of inner vs outer conjugacy of subalgebras of certain graph C*-algebras is investigated. For a large class of finite graphs E, we show that whenever $\alpha$ is a vertex-fixing quasi-free automorphism of the corresponding graph C*-algebra C*(E) such that \alpha(\D_E)\neq\D_E, where \D_E is the canonical MASA in C*(E), then \alpha(\D_E)\...
Article
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The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney diseases, brain dysfunction, tooth fracture, ischemic reperfusion injury, hypertension, impaired reproductive system, and systemic acidosis. Carbonic anhydrases are...
Article
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The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular functions. Although evidence is emerging that cell migration is a physiological/pathological pro...
Chapter
The problem of inner vs outer conjugacy of subalgebras of certain graph C*-algebras is investigated. For a large class of finite graphs E, we show that whenever α is a vertex-fixing quasi-free automorphism of the corresponding graph C*-algebra C* (E) such that α(DE) ̸= DE, where DE is the canonical MASA in C* (E), then α(DE) ̸= wDEw * for all unita...
Article
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Disulfiram has been used in the treatment of alcoholism and exhibits an anti-tumor effect. However, the intracellular mechanism of anti-tumor activity of Disulfiram remains unclear. In this study, we focused on the modulatory role of Disulfiram via oncogenic factor carbonic anhydrase CA12 and its associated transporter anion exchanger AE2 in lung c...
Article
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Despite the lysosomal “proton sponge hypothesis” being considered to be an additional factor for stimulating the cellular toxicity of nanoparticle-based drug delivery systems, a clear relationship between the massive influx of calcium ions and the proton sponge effect, both of which are associated with cancer cell apoptosis, has still not been eluc...
Article
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Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical problems associated with ion imbalance. However, the mechanism of ion imbalance mediated by cardioplegia and a diabetic heart is largely unclear. We hypothesized that ion transporters might be regulated differently in the diabetic heart and that the differentially r...
Article
Nanoparticles (NPs) have been studied as therapeutic drug-delivery agents for promising clinical trial outcomes. Nanomaterial-based drugs can transfer conventional drugs to target lesions, such as tumors, with increasing efficiency by enhancing drug-cell interaction or drug absorption. Although they are favorable as efficient drug transfer systems,...
Article
Although androgen depravation therapy (ADT) and immunotherapy are potential treatment options in men with metastatic prostate cancer (CaP), androgen has conventionally been proposed to be a suppressor of the immune response. However, we herein report that dihydrotestosterone (DHT) activates macrophages. When the murine macrophage cell line (RAW 264...
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Patients carrying the carbonic anhydrase12 E143K mutation showed the dry mouth phenotype. The mechanism underlying the modulation of aquaporin 5 and function in the salivary glands by carbonic anhydrase12 remains unknown. In this study, we identified the mislocalised aquaporin 5 in the salivary glands carrying the E143K. The intracellular pH of E14...
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Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expressed in salivary glands. The ro...
Data
The cholinergic receptor agonist carbachol (1 μM)-evoked intracellular Ca2+ signals with and without BAPTA-AM (BAPTA, 10 μM) in SMG acini (A) and ductal (B) cells. Arrows represent the applied time of agents. (C) The effect of acute carbachol with and without BAPTA-AM (10 μM) on CBE activities of SMG ductal cells. (D) Bars indicate the means ± SEM...
Data
The pH calibration curve for (A) HEK293T, (B) A549, and primary isolated SMG (C) acini and (D) ductal cells at pH 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, and 8.5.
Data
Expression of NBCe1 (red) and NKCC1 (red) in isolated SMG cells. The polyclonal NBCe1 antibody can recognize shared epitope on the NBCe1-A, -B, and -C isoform. (B) The interaction between NBCe1-B and SPL. Input blots were for loading control. (C) The interaction between NKCC1 and SPL. Input blots were for loading control. (D,E) The slope of pHi mea...
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Background: Penile length (PL) shortening is an underreported phenomenon following radical prostatectomy (RP) and risk factors are not fully explored. We aimed to describe longitudinal patterns of PL recovery and evaluate factors predicting complete return to baseline PL. Methods: PL measurement was performed during a preoperative and postoperat...
Article
Enamel is a highly calcified tissue. Its formation requires a progressive and dynamic system for the regulation of electrolyte concentration by enamel epithelia. A critical function of enamel epithelial cells, ameloblasts, is the secretion and movement of electrolytes via various channels and transporters to develop the enamel tissue. Enamel format...
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In article 1700860, Sang‐Hyun Kim, Dongwoo Khang, and co‐workers demonstrate stealth mesenchymal stem cells armed with anti‐cancer nanodrug that successfully eradicate and are mutually destructive with malignant lung cancers. Using this method, the current clinical dose of anticancer drug for the treatment of lung cancer can be decreased by more th...
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Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors t...
Article
Introduction: Enzalutamide is the first approved second-generation androgen receptor (AR) antagonist in the treatment of metastatic castration-resistant prostate cancer (mCRPC) with or without docetaxel-based chemotherapy. Over the past 5 years, a number of attempts were made to determine the efficacy of enzalutamide in the different clinical setti...
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Background: Although the standard treatment for the patients with recurrent and metastatic prostate cancer (CaP) is androgen deprivation therapy, castration-resistant prostate cancer (CRPC) eventually emerges. Our previous report indicated that bone morphogenetic protein 6 (BMP6) induced CRPC via tumour-infiltrating macrophages. In a separate line...
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Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The...
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Objective: To identify the effects of overactive bladder (OAB) symptoms on the health-related quality of life (HRQOL) in stroke patients since OAB symptoms are common in such patients, but their effects on stroke rehabilitation over time are unclear. Methods: This study included 30 post-acute stroke patients who had been admitted for rehabilitat...
Data
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Significance Insulin resistance is a metabolic disorder in which target cells fail to respond to physiological levels of circulating insulin, leading to hyperinsulinemia and glucose intolerance. The molecular mechanism underlying insulin resistance is still largely unknown. Here, we found that intracellular Ca ²⁺ overloading in obesity attenuates i...
Article
Although activating apoptosis in cancer cells by targeting the mitochondria is an effective strategy for cancer therapy, insufficient targeting of the mitochondria in cancer cells restricts the availability in clinical treatment. Here, we report on a polyethylene glycol-coated carbon nanotube-ABT737 nanodrug that improves the mitochondrial targetin...
Chapter
Ca²⁺ influx by plasma membrane Ca²⁺ channels is the crucial component of the receptor-evoked Ca²⁺ signal. The two main Ca²⁺ influx channels of non-excitable cells are the Orai and TRPC families of Ca²⁺ channels. These channels are activated in response to cell stimulation and Ca²⁺ release from the endoplasmic reticulum (ER). The protein that convey...
Article
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Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it has not been established Ca²⁺ signaling mechanisms involved in acute PM-derived signaling in pulmonary fibroblasts. In the present study,...
Article
We investigate the relationship between endomorphisms of the Cuntz algebra ${\mathcal O}_2$ and endomorphisms of the Thompson groups $F$, $T$ and $V$ represented inside the unitary group of ${\mathcal O}_2$. For an endomorphism $\lambda_u$ of ${\mathcal O}_2$, we show that $\lambda_u(V)\subseteq V$ if and only if $u\in V$. If $\lambda_u$ is an auto...
Article
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Dexmedetomidine (Dex), a highly selective α2-adrenoceptor agonist, attenuates inflammatory responses induced by lipopolysaccharide (LPS) and induces sedative and analgesic effects. Administration of Dex also reduces salivary secretion in human subjects and inhibits osmotic water permeability in rat cortical collecting ducts. However, little is know...
Article
Introduction: Phosphodiesterase type 5 inhibitors (PDE5Is) are the first-line drugs in the management of erectile dysfunction (ED). However, over the past two decades tremendous efforts have been made to identify new clinical uses of PDE5Is beyond their roles in ED. Areas covered: Basic science articles, clinical trials, reviews, and meta-analysis...
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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appr...
Article
For a large class of finite graphs $E$, we show that whenever $\alpha$ is a vertex-fixing quasi-free automorphism of the corresponding graph $C^*$-algebra $C^*(E)$ such that $\alpha({\mathcal D}_E) \neq{\mathcal D}_E$, where ${\mathcal D}_E$ is the canonical MASA in $C^*(E)$, then $\alpha({\mathcal D}_E)\neq w{\mathcal D}_E w^*$ for all unitaries $... Article It was shown recently by Conti, R{\o}rdam and Szyma\'{n}ski that there exist endomorphisms$\lambda_u$of the Cuntz algebra$\mathcal{O}_n$such that$\lambda_u (\mathcal{F}_n)\subseteq\mathcal{F}_n$but$u\not\in\mathcal{F}_n$, and a question was raised if for such a$u$there must always exist a unitary$v\in\mathcal{F}_n$with$\lambda_u|_{\math...
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Exposure to bacterial lipopolysaccharides (LPS) induces inflammatory signals in salivary glands. We investigated the regulatory role of phosphodiesterase 4 (PDE4) inhibitor rolipram on inflammatory mediators and cholinergic/adrenergic stimulation-induced intracellular Ca 2+ signaling in salivary acinar and ductal cells. Submandibular gland (SMG) ex...
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Bladder cancer exhibits a broad spectrum of heterogenous clinical behavior. Conventionally used clinicopathological factors are associated with certain limitations regarding the accurate prediction of outcome. Recent studies have focused on the predictive role of cellular regulatory markers. The present case aimed to describe an extremely rare case...
Article
Anion exchanger 2 (AE2) has a critical role in epithelial cells and is involved in the ionic homeostasis such as Cl(-) uptake and HCO3(-) secretion. However, little is known about the regulatory mechanism of AE2. The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3]...
Article
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Bronchial epithelial cells are the first barrier of defense against respiratory pathogens. Dust particles as extracellular stimuli are associated with inflammatory reactions after inhalation. It has been reported that dust particles induce intracellular Ca 2+ signal, which subsequently increases cytokines production such as interleukin- (IL-) 8. Ho...
Article
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Key points: Fluid and HCO3 (-) secretion is essential for all epithelia; aberrant secretion is associated with several diseases. Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secretion and works by activating the ductal Cl(-) -HCO3 (-) exchanger AE2. Delivery of CA12 to salivary glands increases saliv...
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Purpose: Curcumin is a nontoxic, chemopreventive agent possessing multifaceted functions. Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/β-catenin signaling in LNCaP cells. Therefore, we investigated the in vivo effects of curcumin by using LNCaP xenografts. Materials and methods: LNCaP cells we...
Article
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Dexmedetomidine is a sedative and analgesic agent that exerts its effects by selectively agonizing α2 adrenoceptor. Histamine is a pathophysiological amine that activates G protein-coupled receptors, to induce Ca(2+) release and subsequent mediate or progress inflammation. Dexmedetomidine has been reported to exert inhibitory effect on inflammation...