Jeffrey A Johnson's research while affiliated with University of Alberta and other places

Publications (455)

Article
Background: Little is known about the long-term (>2 years) relationship between the time-varying drug adherence and healthcare utilization for patients with diabetes. Objective: To characterize the relationship between time-varying anti-hyperglycemic medication adherence and healthcare utilization in patients with diabetes, using data from Alber...
Article
Objective The objective of this study was to evaluate the effectiveness of an online patient decision aid with individualised potential outcomes of surgery, on the quality of decisions for knee replacement surgery in routine clinical care. Design A pragmatic Randomized Controlled Trial (RCT) in patients considering total knee replacement at a high...
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Objectives To examine the comparative performance of EuroQol EQ-5D-5L and Center for Disease Control Healthy Days measures in assessing population health. Methods Using data from 2014 Alberta Community Health Survey, a cross-sectional population-based survey (N = 7559), conducted in Alberta, Canada, we examined construct validity of the measures a...
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PurposeThe Edmonton Symptom Assessment System-Revised: Renal (ESAS-r: Renal) is a disease-specific patient-reported outcome measure (PROM) that assesses symptoms common in chronic kidney disease (CKD). There is no preference-based scoring system for the ESAS-r: Renal or a mapping algorithm to predict health utility values. We aimed to develop a map...
Article
Objectives To examine the impact of COVID-19 pandemic on health-related quality of life (HRQL) of adults visiting emergency departments (ED) and primary care (PC) settings in Alberta, Canada, and explore whether this impact varies across demographic subgroups.Methods Data from two repeated cross-sectional surveys that measured HRQL using EQ-5D-5L w...
Article
Aims In Canada, the National Diabetes Surveillance System (NDSS) identifies a case of diabetes using administrative health records as “two physician claims or one hospital discharge abstract record, within a two-year period for a diagnosis bearing International Classification of Disease (ICD) codes for diabetes”. The NDSS case definition was compar...
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Background We aimed to describe (1) depressive and anxiety symptom burdens reported by adults on in-centre hemodialysis in Northern Alberta, Canada and (2) patients’ and nurses’ perceptions of managing such symptoms using routine patient-reported outcome measures (PROMs). Methods A longitudinal mixed methods approach was employed. Cluster randomiz...
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Background We propose a modified quality-adjusted life year (QALY) calculation that aims to be consistent with guidance for interpreting change in patient-reported outcomes. This calculation incorporates the minimally important difference (MID) in generic preference-based health-related quality of life (HRQL) change scores to reflect what might be...
Article
Objective This study aims to determine how population-based health-utility score (HUS) differences reflect individuals’ health preferences using responses from the Canadian EQ-5D-5L Valuation Study, including time trade-off (TTO) and discrete-choice experiment (DCE) tasks (n=1073). Study Design and Setting Cardinal TTO responses were transformed i...
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Introduction Alberta's Tomorrow Project (ATP) is the largest population-based prospective cohort study of cancer and chronic diseases in Alberta, Canada. The ATP cohort data were primarily self-reported by participants on lifestyle behaviors and disease risk factors at the enrollment, which lacks sufficient and accurate data on chronic disease diag...
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Many healthcare systems around the world have been increasingly using patient-reported outcome measures (PROMs) in routine outcome measurement to enhance patient-centered care and incorporate the patient’s perspective in health system performance evaluation. One of the key steps in using PROMs in health systems is selecting the appropriate measure(...
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Kidney failure requiring dialysis is associated with high symptom burden and low health-related quality of life (HRQL). Patient-reported outcome measures (PROMs) are standardized instruments that capture patients' symptom burden, level of functioning, and HRQL. The routine use of PROMs can be used to monitor aspects of patients' health that may oth...
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PurposeTo examine whether the EQ-5D-3L at the time of discharge from hospital provides additional prognostic information above the LACE index for 30-day post-discharge hospital readmission and to explore the association of EQ-5D-3L with readmissions, emergency department (ED) visits, and death within the same period.Methods Using data (n = 495; mea...
Article
Purpose Diabetes patients with non-infected neuroischemic diabetic foot ulcers (DFU) treated with sucrose octasulfate (SOS) dressing have been shown to have improved healing compared to patients wearing a similar type of dressing without SOS. This study aimed to estimate the cost-effectiveness of SOS dressing compared to conventional dressings from...
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Background In 2012, the Government of Alberta introduced a funding program to remunerate pharmacists to develop a comprehensive annual care plan (CACP) for patients with complex needs. The objective of this study is to explore patients’ perceptions of the care they received through the pharmacist CACP program in Alberta. Methods We invited 3442 pa...
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Background Diabetes care remains suboptimal in First Nations populations. Innovative and culturally relevant approaches are needed to promote systematic and proactive organization of diabetes care for people living with diabetes on-reserve in Canada. The RADAR model is one strategy to improve care: an integrated disease registry paired with an elec...
Article
BACKGROUND: The management of chronic diseases is a continuing challenge for health care systems and patients. OBJECTIVE: To assess the effect of a pharmacist-specific chronic diseases management incentive plan (the Comprehensive Annual Care Plan [CACP]) implemented by the government of Alberta (Canada) on adherence to lipid-lowering drugs (LLD) am...
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Background To examine the performance of the EQ-5D-3L in screening for anxiety and depressive symptoms in hospital and community settings compared to other patient-reported screening tools. Methods Data from a prospective cohort of patients discharged from general internal medicine wards from two hospitals in Edmonton, Alberta were used in this st...
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Objective To investigate the perceived effects of the coronavirus disease (COVID-19) pandemic lockdown measures on food availability, accessibility, dietary practices, and strategies used by participants to cope with these measures. Design We conducted a cross-sectional multi-country online survey between May and July 2020. We used a study-specifi...
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Objective To determine the efficacy and safety of low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) for people with type 2 diabetes. Design Systematic review and meta-analysis. Data sources Searches of CENTRAL, Medline, Embase, CINAHL, CAB, and grey literature sources from inception to 25 August 2020. Study selection Randomiz...
Preprint
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Background: Diabetes care remains suboptimal in First Nations populations. Innovative and culturally relevant approaches are needed to promote systematic and proactive organization of diabetes care for people living with diabetes on-reserve in Canada. The RADAR model is one strategy to improve care: an integrated disease registry paired with an ele...
Article
Full-text available
PurposeThe EQ-5D-5L is a commonly used instrument for assessing the utility of different health states. Health state utility values are a key component of health technology evaluations. Such evaluations are used to support evidence-based decisions surrounding health resource allocations and therefore rely on the accuracy of the valuation set used....
Article
Background: The prevalence of metabolic syndrome is growing worldwide, yet remains underinvestigated in Canadian young adults. We sought to explore the use of a harmonized case definition specific to early-onset metabolic syndrome and determine its feasibility in assessing the prevalence of metabolic syndrome among electronic medical record (EMR)...
Article
Objectives: To characterize the population of patients who received a pharmacist-billed comprehensive annual care plan (CACP) in Alberta and to evaluate any changes in health care use for such patients, including physician visits, hospitalizations, and emergency department (ED) visits. Methods: We used administrative data from Alberta Health to...
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Background: Kidney failure requiring dialysis is associated with poor health outcomes and health-related quality of life (HRQL). Patient-reported outcome measures (PROMs) capture symptom burden, level of functioning and other outcomes from a patient perspective, and can support clinicians to monitor disease progression, address symptoms, and facil...
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Objectives Rigorous evidence is needed to support uptake of recommendations to include low glycemic index (GI) foods in daily meal planning as an effective dietary self-care strategy for people with type 2 diabetes (T2D). We evaluated the effectiveness of a 12-week web-based GI-targeted nutrition education intervention on dietary intakes and GI-rel...
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Background: Diabetes care is suboptimal in First Nations populations. Innovative and culturally-relevant approaches are needed to promote proactive organization of diabetes care for diabetes patients on-reserve in Canada. The Reorganizing the Approach to Diabetes care through the Application of Registries (RADAR) model is one strategy to improve c...
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Objective Thresholds defining medication adherence are rarely evidence-based. A threshold of 0.8 is typically presumed to achieve improved outcomes. We aimed to assess the optimal threshold of adherence to lipid-lowering drugs (LLD) in predicting cardiovascular-related (CV) outcomes in patients with hypertension. Design Cohort study of new users o...
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Purpose To examine the responsiveness of the EQ-5D-3L and EQ-5D-5L among total hip/knee replacement (THR/TKR) patients. Methods The EQ-5D (3L or 5L) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) have been routinely administered to all THR/TKR patients before and at 3 months after surgery in Alberta, Canada, since 2010. P...
Article
Objectives: The aim of this study was to assess the association between diabetic foot disease and health-related quality of life (HRQOL) during a 2-year follow up among people with type 2 diabetes in Alberta. Methods: A type 2 diabetes cohort was established (2011‒2013); those with self-reported diabetic foot disease were identified. HRQOL was a...
Article
Purpose: To assess agreement between the Pharmaceutical Information Network (PIN), a newly implemented medication data repository in Alberta, Canada, and the Alberta Blue Cross (ABC) database, a long established database with medication records of all senior patients in Alberta. Methods: PIN data (2008-2015) were cross-validated with ABC medicat...
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Objectives To characterise the sex-specific difference in the association between anthropometric changes and risk of diabetes in the general population in Canada. Setting and participants From 2000 to 2008, Alberta’s Tomorrow Project (ATP) invited Alberta’s residents aged 35–69 years to a prospective cohort study. A total of 19 655 diabetes-free A...
Article
Aims: Pneumococcal vaccination is recommended in diabetes because of the high risk for invasive pneumococcal disease and mortality; however, vaccination rates are below recommended targets. This study was conducted to identify possible reasons behind the low rate of vaccine uptake. Methods: We examined baseline information from the Alberta Carin...
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Purpose: Women who are diagnosed with gestational diabetes mellitus have an increased risk of developing type 2 diabetes, but most receive little guidance regarding disease prevention. This study examined the role and usefulness of social support, including peer counselling in facilitating behaviour change as a part of a healthy eating and physical...
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Background The EQ-5D-5 L and the SF-12 are the most commonly used generic measures of health-related quality of life among people with arthritis. However, there is little evidence on the extent to which the individual dimensions and domains of these instruments perform among this population. The objective was to examine the discriminative validity...
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Background Health-related quality of life (HRQL) is increasingly recognized for its importance in health research. As there is increasing recognition of the inter-individual difference in response to therapeutic interventions, it may be helpful to apply individualized measures of HRQL. The MYMOP is a commonly used example of such measures, although...
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Background: There is increasing recognition that health care professionals often fail to provide meaningful obesity care in routine clinical practice. There is scant information on how to support practice change. The objective of the 5AsT trial was to assess whether a co-created educational intervention would increase the quantity of obesity visit...
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Background: Osteoporosis is a chronic condition that is often left untreated. Nurse case-managers can double rates of appropriate treatment in those with new fractures. However, little is known about patients' experiences of a nurse case-managed approach to osteoporosis care. Objective: Our aim was to describe patients' experiences of nurse case...
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Background While the rates of total knee arthroplasty (TKA) continue to rise worldwide, there are concerns about whether all surgeries are appropriate. Guidelines for appropriateness suggest that patients should have realistic expectations for total knee arthroplasty (TKA), and that the patient and their surgeon should agree that the potential bene...
Article
Background: To prevent diabetic foot disease, proper foot care is essential for early detection and treatment. Pharmacists are well suited to provide accessible foot care to adults with type 2 diabetes. Limited research has examined this role. Methods: We conducted a systematic review of community pharmacy-based and pharmacist-led foot care inte...
Article
Background: As a generic measure of health-related quality of life among patients awaiting THA or TKA, the three-level version of the EQ-5D (EQ-5D-3L), which has three response levels of severity (no problems, some problems, and extreme problems/unable) to five questions, is widely used. Previous studies indicated that the ceiling effect of the EQ...
Data
Multinomial logistic regression model for Weight status transition probabilities. (DOCX)
Article
We assessed the cost‐effectiveness of two models of osteoporosis care after upper extremity fragility fracture using a high‐intensity Fracture Liaison Service (FLS) Case‐Manager intervention versus a low‐intensity FLS (i.e., Active Control), and both relative to usual care. This analysis used data from a pragmatic patient‐level parallel‐arm compara...
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Purpose: To examine the relationship of neighbourhood-level material and social deprivation with health-related quality of life, measured by the EQ-5D-5L, in the general adult population. Methods: A sample of 11,835 adults living in Alberta, Canada was drawn from three combined annual Health Quality Council of Alberta Satisfaction and Experience...
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Background Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk factor combinations, includin...
Article
Objectives: To examine the association of depressive symptoms (DS) and diabetes-related distress (DD) with severe hypoglycemia (SH) in adults with type 2 diabetes. Methods: Baseline data from a cohort study of adults with type 2 diabetes (N=2,040) were used. The Patient Health Questionnaire 8-items and Problem Areas in Diabetes 5-items questionn...
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IntroductionAlberta’s Tomorrow Project (ATP) is a province-wide cohort study of cancer and chronic diseases in Canada. Approximately 55,000 Albertans aged 35-69 years with no history of cancer, other than non-melanoma skin cancer, had joined the ATP. Nearly all (>96%) ATP participants consented to data linkage to administrative healthcare databases...
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IntroductionPharmaceutical Information Network (PIN, 2008-now) is a provincial database collecting patients’ medication information in Alberta, Canada. Alberta Blue Cross (ABC), the largest health benefit provider in Alberta, has been managing pharmaceutical records for senior patients (65+ years) whose medications are covered by Alberta’s governme...
Article
Background: Rigorous evidence is needed regarding the best approach for increasing the uptake of Diabetes Canada's evidence-based recommendations to include low-glycemic index (GI) foods in daily meal planning as an effective dietary self-care strategy for glycemic control among people with type 2 diabetes (T2D). Objective: This study aims to pr...
Preprint
BACKGROUND Adults with type-2 diabetes mellitus (T2DM) who receive enhanced glycemic index (GI) concept education may increase self-efficacy to include low-GI foods in their daily meal planning, resulting in improved glycemic control, compared to those receiving usual care. OBJECTIVE To examine the effectiveness of enhanced GI-targeted nutrition e...
Article
We compared osteoporosis care after upper extremity fragility fracture using a low‐intensity Fracture Liaison Service (FLS) versus a high‐intensity FLS in a pragmatic patient‐level parallel‐arm comparative effectiveness trial undertaken at a Canadian academic hospital. A low‐intensity FLS (active‐control) that ‘identified’ patients and notified pri...
Article
Aims: Self-efficacy is presumed important in chronic disease management; we assessed the association between self-efficacy and risk of hospitalization in adults with type-2 diabetes. Methods: A prospective cohort was assembled between December 2011 to December 2013. Participants completed an extensive survey, including a previously validated 6-i...
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Objective. To evaluate the performance of EQ-5D-5L (EuroQol Five-Dimension, Five-Level Questionnaire) and SF-12-v2 (12-item Medical Outcomes Health Survey–Short Form, Version 2) in screening for anxiety and depressive symptoms in adults with type 2 diabetes. Methods. Cross-sectional data from a population-based study of type 2 diabetes in Alberta,...
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Background: Anxiety and depression disorders are associated with significantly lower health-related quality of life (HRQL). The EQ-5D is a commonly used generic measure of HRQL; it captures mental health through a single domain-the anxiety/depression dimension. Evidence on the responsiveness of this measure in assessing changes in mental health ch...
Article
Background: The EuroQol five-dimensional questionnaire (EQ-5D) is a generic preference-based measure of health-related quality of life, and several studies have made attempts to estimate the minimally important difference (MID) for the EQ-5D index score. Objectives: To estimate the MID of the five-level EQ-5D (EQ-5D-5L) index score in a populati...
Article
Objective Health-related quality of life (HRQL) instruments are patient or proxy-reported outcome measures that provide a comprehensive and subjective assessment of patient’s well-being and hence vital for health outcomes evaluation. A clear and thorough understanding of HRQL and its determinants is especially important to appropriately guide healt...
Data
Standardized incidence ratio of obesity-related cancers. Cancers included: liver, kidney, colorectal, gallbladder, pancreas, ovarian, endometrial and advanced prostate cancer, post-menopausal breast cancer and esophageal adenocarcinoma. (DOCX)
Data
Standardized incidence ratio all cancers combined. (DOCX)
Data
Standardized incidence ratio of all and obesity-related cancer stratified to BMI <> 30 in women. (TIF)
Data
Standardized incidence ratio breast cancer (women) and advanced prostate cancer (men). (DOCX)