Jeffrey A Gusenoff’s research while affiliated with Johns Hopkins University and other places

Infected wounds after total hip arthroplasty can be limb threatening. Management strategies are designed to eradicate infection, to obtain stable wound coverage, and to preserve the prosthesis. However, there is no general consensus for optimal management. The authors reviewed their 7-year combined orthopaedic and plastic surgical experience to provide a protocol for management. Ten patients (six women and four men) with a mean age of 60 years (range, 41-82 years) were studied. Primary hip diagnoses included arthritis (n = 8) and avascular necrosis (n = 2). Wound analysis included the size, depth, and infection as well as exposure of bone, joint capsule, and prosthetic components. Follow-up ranged from 1 to 6 years (mean, 3.9). Primary plastic surgical operations included a pedicle muscle flap (n = 4), debridement and local wound care (n = 3), and delayed wound closure (n = 3). Salvage of the total hip arthroplasty was achieved in 6 of 10 patients. Complete wound healing was achieved in 9 of 10 patients. The authors conclude that salvage of the infected hip prosthesis is accomplished best via early recognition, irrigation, debridement, and plastic surgery consultation. Management strategies include muscle flap coverage for complex wounds associated with exposure of prosthetic components, bone, or hardware; debridement with delayed closure or skin graft for large superficial wounds without deep structure involvement; and local wound care for small superficial wounds, poor surgical candidates with clean wounds, and when surgical options are not possible.

Pressure sores are a common complication of long-term institutional care. Surgical coverage of late-stage ulcers in the elderly refractory to conservative therapy remains controversial. The authors reviewed the outcome of 22 predominately nonambulatory, nonparaplegic, elderly patients with coverage of 27 pressure sores. The mean patient age was 59 years (range, 50-82 years). The average follow-up was 6 months (range, 3 months-2 years). There were 11 complications for the 22 patients (50%) and the 27 ulcers (41%). Postoperatively, a well-healed ulcer was present in 19 of 27 patients (70%) at 6 months. Of the 19 reconstructed sacral ulcers, there were 10 complications (53%) and one recurrence at 6 months. Seven trochanteric ulcers were covered with tensor fascia lata flaps without complications or recurrences at the 6-month follow-up. One ischial ulcer was managed using a V-Y hamstring advancement flap, resulting in dehiscence and a subsequent revision. The authors advocate surgical coverage to treat late-stage pressure sores in nonparalyzed elderly persons to reduce the morbidity, mortality, and economic burden of patients with late-stage pressure ulcers. With an increasing geriatric population, prevention and postoperative care are necessary to diminish the incidence, recurrence, and burden of pressure sores.

We studied 130 healthy aged women (n = 57) and men (n = 73), age 65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these relationships differ by sex. Blood was sampled every 20 min from 8:00 PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric assay, followed by deconvolution analyses of hormone secretory parameters and assessment of approximate entropy (ApEn) and cross-ApEn. Cortisol mass/burst, cortisol production rate, and mean and integrated serum cortisol concentrations (P < 0.0005), and overnight basal GH secretion (P < 0.05), were elevated in women vs. men. Integrated cortisol concentrations were directly related to most measures of GH secretion in women (P < 0.01) and with mean and integrated GH concentrations in men (P < 0.05). Integrated GH concentrations were directly related to mean and integrated cortisol levels in women (P < 0.005) and men (P < 0.05), with no sex differences. There were no sex differences in cortisol or GH ApEn values; however, the cross-ApEn score was greater in women (P < 0.05), indicating reduced GH-cortisol pattern synchrony in aged women vs. men. There were no significant relationships of integrated cortisol secretion with GH ApEn, or vice versa, in either sex. Thus postmenopausal women appear to maintain elevated cortisol production in patterns that are relatively uncoupled from those of GH, whereas mean hormone outputs remain correlated.