Jean-Christophe Plantier’s research while affiliated with French Institute of Health and Medical Research and other places

... Chinese patients infected with CRF07_BC showed better correlation with immune recovery after ART compared to those infected with CRF01_AE [34,35]. Notably, while subtype B was associated with virulence enhancement, similar phenomenon was also observed in other CRFs in regions with high recombination rates [36]. This suggests that virulence enhancement may be a broader evolutionary adaptation rather than a subtype-specific trait, underscoring the need for longitudinal studies to track viral dynamics across different genetic backgrounds. ...

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Characteristics of molecular epidemiology and transmitted drug resistance among newly diagnosed HIV-1 infections in Lishui, China from 2020 to 2023

... Currently, one of the most intriguing questions is the capability of RSV to establish a breakthrough infection, a term that describes RSV infection in infants who were administrated with nirsevimab. A study by Fourati et al. [122] analyzed 260 full-length RSV genome sequences from nirsevimab-treated breakthrough infections that occurred in France during the 2023-24 RSV season. In accordance with results obtained in nirsevimab late-phase clinical trials [32], low levels of nirsevimab-related resistance mutations were observed. ...

Reference:

Passive Immunization in the Prevention and Treatment of Viral Infections

... The recent Coronavirus disease 2019 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently expanded the clinical scenarios of A. fumigatus infection to include COVID-19-associated pulmonary aspergillosis (CAPA) [4][5][6][7]. A multicenter study in France reported a 15% prevalence of CAPA in critically ill patients requiring invasive mechanical ventilation during the first wave [8], and a 5.1% prevalence in the Delta and Omicron waves, which rose to 9.1% among patients who required invasive mechanical ventilation [9]. Along with influenza-associated pulmonary aspergillosis, CAPA represents a form of viral-associated pulmonary aspergillosis in which a severe viral infection, likely by disrupting epithelial integrity and inducing a severe inflammatory response in critical patients, predisposes to the development of invasive fungal infection [7]. ...

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Protective Effect of Indole-3-Aldehyde in Murine COVID-19-Associated Pulmonary Aspergillosis

... Esta pesquisa, realizada com estudantes universitários brasileiros, identificou que a maioria desse público tinha níveis de conhecimento adequados, atitudes e práticas positivas sobre a COVID-19, além de percepção de risco moderada sobre essa doença. Semelhantemente, outras pesquisas, realizadas com estudantes universitários, também identificaram conhecimentos adequados, atitudes e práticas positivas em relação à COVID-19 (13)(14)(15) . Esses achados podem estar relacionados ao fato de os en-trevistados desses estudos serem indivíduos com maior nível de escolaridade, visto que há influência dessa variável (16) . ...

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CONHECIMENTOS, ATITUDES E PRÁTICA DE ESTUDANTES UNIVERSITÁRIOS SOBRE A COVID-19: ESTUDO TRANSVERSAL

... In our study, we aim to evaluate the performance of a new cost-effective Mindray CL-900i-HIV Ag/Ab combo assay from Mindray-China as an alternative screening method to the well-established ARCHITECT ® HIV Ag/Ab combo assay [17][18][19] . In addition, we compared the performance of the Mindray CL-900i-HIV Ag/Ab combo assay against the gold standard INNO-LIA™ HIV I/II confirmatory assay 20 . We also included a surrogate reference method, PCR, in our evaluation. ...

Reference:

Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods

... The ΔHV69-70 deletion in the S gene, initially associated with the Alpha variant, has also been effective in differentiating between Omicron sublineages, such as BA.1 from BA.2 [29][30][31] and BA.4/BA.5 from BA.2 [32]. Here, our screening method, which utilizes the ΔHV69-70 deletion as a primary marker, demonstrated a predominance of BA.4/BA.5 over BA.2 from June to September 2022 (90.3% vs. 9.7%). ...

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Use of allele-specific qPCR and PCR-RFLP analysis for rapid detection of the SARS-CoV-2 variants in Tunisia: A cheap flexible approach adapted for developing countries

... This huge genetic diversity of HIVs is mainly attributed to (i) their simian origins, involving at least 13 independent cross-species transmission events from great apes (HIV-1) or monkeys (HIV-2) to humans (Supporting Information S1: Figure 1), (ii) their replication properties characterized by a high replication rate with an important daily production of virions and a low fidelity of reverse transcriptase (RT), and (iii) the host selection pressure, which facilitates the establishment of quasispecies [8][9][10]. The co-circulation of different variants within the same geographic area often results in dual infections, as described with subtypes for HIV-1/M, subgroups for HIV-1/O or with HIV-1 and HIV-2 [11][12][13][14][15]. The dual infections may lead to the emergence of recombinant forms. ...

Reference:

Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms

... However, a follow-up have been performed for five patients monitored in France, giving first data on immune-virological response to combined ART (cART). For four of them (BCF204, RBF208, BCF212 and RBF243), the last point of follow-up showed a cART efficacy, demonstrating the efficiency of an adapted management taking into account the variant[85]. For the last one (RBF235), the last point of follow-up showed a virological failure after several distinct regimens (including NNRTIs), partially explained by an undiagnosed HIV-1/M+O dual infection and to adherence difficulties[68]. ...

Reference:

Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms

... Consequently, we could not analyze the severity of infection in the patients enrolled in this study. It was reported that patients infected with SARS-CoV-2 recombinant viruses showed low clinical severity until infection with the XD strain, a recombinant of the Delta and Omicron variants [21]. Thus, recombinant viruses originating from the Delta and Omicron variants may cause clinical symptoms with low severity. ...

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Identification of Various Recombinants in a Patient Coinfected With the Different SARS‐CoV‐2 Variants

... Another observational study specifically focused on the virological response of patients receiving the combination containing bictegravir [103]. We found 6% of the cohort received the combination, with 75% already in virological success from a previous antiretroviral combination. ...

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HIV-1 Non-Group M Strains and ART