Javier Garrosa's research while affiliated with Hospital Clínico San Carlos and other places

Publications (4)

Article
Full-text available
Ischemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural support function. They have been perfected, different compounds have been combined, and they have been used toge...
Article
Full-text available
Calcium homeostasis modulator 1 (CALHM1) is a calcium channel involved in the regulation of cytosolic Ca2+ levels. From a physiological point of view, the open state of CALHM1 depends not only on voltage but also on the extracellular concentration of calcium ([Ca2+]) ions. At low [Ca2+]e or depolarization, the channel is opened, allowing Ca2+ influ...

Citations

... We have already confirmed the potential of human umbilical blood-derived endothelial precursor cells by our artificial vascular tissue-constructing technique (unpublished data). Endothelial cells from these sources will enable to construct transplantable artificial vascular tissues as materials for regenerative medicine of ischemic diseases such as ischemic heart disease, ischemic stroke, and chronic limb ischemia [56][57][58] . For this purpose, further analysis and assessment of vascular function, engraftment persistence, and safety in clinical usage are needed. ...
... It may also impair neuronal function in the brain and increase susceptibility to neurodegenerative diseases during aging [29,30]. In addition, the depletion of calcium homeostasis modulator 1, a calcium channel involved in the regulation of intracellular Ca 2+ levels, was found to downregulate the production of ROS, activate the expression of hypoxia inducible factor-1α, and show neuroprotective effects [31]. ...