Jared Treverton’s research while affiliated with McMaster University and other places

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Publications (2)


A clinical and immunological overview of HIT and VITT.
Vaccine-Induced Immune Thrombotic Thrombocytopenia: Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders
  • Literature Review
  • Full-text available

February 2024

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57 Reads

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11 Citations

Yi Zhang

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Anna-Lise Bissola

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Jared Treverton

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[...]

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Ishac Nazy

Introduction: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare yet severe adverse complication first identified during the global vaccination effort against SARS-CoV-2 infection, predominantly observed following administration of the ChAdOx1-S (Oxford-AstraZeneca) and Ad26.CoV2.S (Johnson & Johnson/Janssen) adenoviral vector-based vaccines. Unlike other anti-platelet factor 4 (PF4) antibody-mediated disorders, such as heparin-induced thrombocytopenia (HIT), VITT arises with the development of platelet-activating anti-PF4 antibodies 4–42 days post-vaccination, typically featuring thrombocytopenia and thrombosis at unusual sites. Aim: To explore the unique properties, pathogenic mechanisms, and long-term persistence of VITT antibodies in patients, in comparison with other anti-PF4 antibody-mediated disorders. Discussion: This review highlights the complexity of VITT as it differs in antibody behavior and clinical presentation from other anti-PF4-mediated disorders, including the high incidence rate of cerebral venous sinus thrombosis (CVST) and the persistence of anti-PF4 antibodies, necessitating a re-evaluation of long-term patient care strategies. The nature of VITT antibodies and the underlying mechanisms triggering their production remain largely unknown. Conclusion: The rise in awareness and subsequent prompt recognition of VITT is paramount in reducing mortality. As vaccination campaigns continue, understanding the role of adenoviral vector-based vaccines in VITT antibody production is crucial, not only for its immediate clinical implications, but also for developing safer vaccines in the future.

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Vaccine-Induced Immune Thrombotic Thrombocytopenia—Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders

December 2023

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40 Reads

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2 Citations

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but severe adverse event that was first observed during the global vaccination campaign against SARS-CoV-2 infection, specifically in those receiving adenoviral vector-based vaccines for Coronavirus disease 2019 (COVID-19). VITT develops 4 to 42 days post-vaccination and is characterized by the development of platelet-activating anti-platelet factor 4 (PF4) antibodies, leading to thrombocytopenia and thrombosis at unusual sites. The rise in awareness and subsequent prompt recognition of VITT was paramount in reducing mortality. Moreover, as vaccination campaigns around the world continue, a better understanding of VITT not only has important clinical implications but is also crucial for future vaccine development. In this review, we summarize the clinical features, pathophysiology, and incidence rates of VITT as well as highlight other anti-PF4 antibody-mediated disorders of growing clinical significance.

Citations (1)


... Було висунуто гіпотезу, що після ін'єкції вакцини імуногенні PF4/ поліаніонні комплекси можуть утворюватися та системно циркулювати, залучаючи моноцити та нейтрофіли через FcγIIa рецептор-залежні механізми (рис. 3) [52]. За їх даними, ВІІТТ переважно проявляється після первинного введення певних вакцин проти COVID-19 на основі аденовірусного вектора з дефіцитом реплікації, а саме вакцин ChAdOx1-S (Oxford-AstraZeneca) і Ad26.CoV2.S (Johnson & Johnson/Janssen), і лише у рідкісних випадках при введенні бустерних доз. ...

Reference:

РОЛЬ SARS-CОV-2 У РОЗВИТКУ СЕНСОНЕВРАЛЬНОЇ ПРИГЛУХУВАТОСТІTHE ROLE OF SARS-CОV-2 IN THE DEVELOPMENT OF SENSORINEURAL HEARING LOSS
Vaccine-Induced Immune Thrombotic Thrombocytopenia: Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders