Janosch Hildebrand's research while affiliated with University of Applied Sciences Coburg and other places
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Publications (6)
Background
Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Under...
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentati...
Integrity of human skin is endangered by exposure to UV irradiation and chemical stressors, which can provoke a toxic production of reactive oxygen species (ROS) and oxidative damage. Since oxidation of proteins and metabolites occurs virtually instantaneously, immediate cellular countermeasures are pivotal to mitigate the negative implications of...
The terminal differentiation of epidermal keratinocytes requires transcriptional and posttranscriptional regulatory mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs that play key roles during differentiation processes by regulating protein expression at the posttranscriptional level. Several studies have investigated miRNA expression in muri...
ejd.2012.1828 Auteur(s) : Janosch Hildebrand1,a, Florian Sporl1,2,a, Sandra Korge1, Stefan Gallinat1, Horst Wenck1, Wolfgang Deppert3, Anja Knott1, Thomas Blatt1 thomas.blatt@beiersdorf.com 1 R &D, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany 2 Laboratory of Chronobiology, Charite Universitatsmedizin Berlin, Germany 3 Heinrich-Pette-Instit...
Here, we report a comprehensive investigation of changes in microRNA (miRNA) expression profiles on human keratinocyte (HK) differentiation in vitro and in vivo. We have monitored expression patterns of 377 miRNAs during calcium-induced differentiation of primary HKs, and have compared these patterns with miRNA expression profiles of epidermal stem...
Citations
... Soderberg et al. [112] described the substantial decrease in CoQ 10 levels in various brain areas between the ages of 30 and 90 years. CoQ 10 levels in the skin epidermis are also reported to decrease as a result of ageing [113][114][115]. ...
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... Endogenous levels of Cq10 in the skin decrease with age and are significantly reduced under the influence of external factors such as UV radiation and pollution (Barcelos, Haas, 2019). Topical treatment with Cq10 can replenish its levels in the skin and have antioxidant effects (Knott et al., 2015). Grether-Beck et al. (2014) studied the effect of incorporating antioxidants such as grape seed extract, Vit. ...
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... Redox modulation of GAPDH has also been proposed as a cellular response to oxidative stress, rerouting intermediates from glycolysis to the PPP with consequent enhanced production of NADPH [71], a process recently reported to occur in a coordinated manner with up-regulation of G6PDH [72]. Interestingly, in human skin fibroblasts and keratinocytes, kinetic-LC-MS analysis of intermediates has provided evidenced that the rerouting of glycolysis intermediates to the PPP can also occur independently of GAPDH inactivation [73], an effect explained in E. coli by the allosteric inhibition of G6PDH mediated by NADPH [74]. Recent investigations of the adaptative responses of cells towards oxidative environments, have provided evidence that the modulation of the PPP is a rapid and essential acute response to oxidative insults [73]. ...
... They evaluated their use as biomarkers of disease activity and the tendency for malignant transformation [37]. MiR-27b has been associated with human keratinocyte differentiation in vitro and in vivo and regulates the expression of matrix metalloproteinase 13 and the transforming growth factor-beta (TGF-beta)/bone morphogenetic protein signaling, immune response, and chronic inflammation [37,38]. Other studies reported a reduction in the expression of miR-27b in OSCC specimens, assuming this miRNA's role as a tumor suppressor through targeting the MET oncogene in this disease [39]. ...
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... The KCTD protein plays an important role in proliferation, differentiation, apoptosis and metabolism (Liu et al., 2013). In addition, Cdkn1c reduces cell differentiation efficiency when it is downregulated (Hildebrand et al., 2012;Eggermann et al., 2014). It is worth noting that Ifitm1 acts as a regulator of many cellular functions. ...
... MiRNA-203a is a keratinocyte-derived miRNA involved in the balance of keratinocyte proliferation and differentiation and is considered a marker of keratinocyte differentiation [54]. MiRNA-203a has reportedly been upregulated in psoriasis skin lesions [55][56][57] and plasma [58]. ...
