Janosch Hildebrand's research while affiliated with University of Applied Sciences Coburg and other places

Publications (6)

Article
Full-text available
Background Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Under...
Article
Full-text available
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentati...
Article
Integrity of human skin is endangered by exposure to UV irradiation and chemical stressors, which can provoke a toxic production of reactive oxygen species (ROS) and oxidative damage. Since oxidation of proteins and metabolites occurs virtually instantaneously, immediate cellular countermeasures are pivotal to mitigate the negative implications of...
Chapter
The terminal differentiation of epidermal keratinocytes requires transcriptional and posttranscriptional regulatory mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs that play key roles during differentiation processes by regulating protein expression at the posttranscriptional level. Several studies have investigated miRNA expression in muri...
Article
ejd.2012.1828 Auteur(s) : Janosch Hildebrand1,a, Florian Sporl1,2,a, Sandra Korge1, Stefan Gallinat1, Horst Wenck1, Wolfgang Deppert3, Anja Knott1, Thomas Blatt1 thomas.blatt@beiersdorf.com 1 R &D, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany 2 Laboratory of Chronobiology, Charite Universitatsmedizin Berlin, Germany 3 Heinrich-Pette-Instit...
Article
Full-text available
Here, we report a comprehensive investigation of changes in microRNA (miRNA) expression profiles on human keratinocyte (HK) differentiation in vitro and in vivo. We have monitored expression patterns of 377 miRNAs during calcium-induced differentiation of primary HKs, and have compared these patterns with miRNA expression profiles of epidermal stem...

Citations

... Poor wound healing was first observed in older soldiers in World War I [15], and more rigorous experimental evidence in rats and other animals has also revealed delayed wound healing in aged tissues [16][17][18][19][20]. Delayed wound healing in aged adults contributes to various health complications and decreased lifespan, which needs to be solved urgently [21]. ...
... Increased topical use of this antioxidant facilitates combat against free radical damage and preserves the skin's healthy cells. This nutrient is easily absorbed through the pores and skin and helps stimulate collagen manufacturing, which allows for improving the elasticity and texture [62,63]. ...
... Reactive oxygen species (ROS) are produced in a wide range of physiological processes, including aerobic respiration (Kalyanaraman et al. 2018), exposure to environmental agents such as UV irradiation (Kuehne et al. 2015) and drugs/xenobiotics (Van Acker et al. 2017), and immune response in higher organisms (Nathan et al. 2013;Yang et al. 2013). The resultant ROS can lead to oxidative stress by directly or indirectly damaging DNA, proteins, and lipids (Nathan et al. 2013). ...
... While ESCs and differentiated keratinocytes are at different stages of the same developmental process, their biological features are markedly different, most likely due to differential miRNA expression (13). However, the differential expression, function and mechanism of miRNA in ESCs and differentiated keratinocytes remain unclear (14). ...
... However, little is known about the role of Cdkn1c, a recently discovered Cip/Kip family member, in odontogenesis. p57 KIP2 , encoded by the Cdkn1c gene, is a major regulator of cell cycle progression (Hildebrand et al. 2012), and is vital in cell proliferation and differentiation (Pateras et al. 2009). p57 KIP2 inhibits cyclin/cyclin-dependent kinase (CDK) complexes in the G1 phase, leading to the inhibition of phosphorylation of the retinoblastoma (Rb) protein, and resulting in suppression of E2F family members in the mid-G1 phase (Tury et al. 2012). ...
... Through the regulation of p63 expression, miR203 maintained the proliferative and differentiation potential of basal keratinocytes as well as precursor cells [68]. Besides miR-203, miR-23b was found to be a second miRNA highly expressed in differentiated keratinocytes, identifying it as a differentiation marker for human skin [69]. ...