Jamie Beros's research while affiliated with University of Western Australia and other places

Publications (4)

Preprint
Static magnetic stimulation (SMS) is a form of non-invasive brain stimulation that can alter neural activity and induce neural plasticity that outlasts the period of stimulation. While SMS is typically delivered for short periods (e.g., 10 minutes) to alter corticospinal excitability or motor behaviours, the plasticity mechanisms that can be induce...
Article
Full-text available
During development of retinofugal pathways there is naturally occurring cell death of at least 50% of retinal ganglion cells (RGCs). In rats, RGC death occurs over a protracted pre- and early postnatal period, the timing linked to the onset of axonal ingrowth into central visual targets. Gene expression studies suggest that developing RGCs switch f...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is a form of non-invasive brain stimulation frequently used to induce neuroplasticity in the brain. Even at low intensities, rTMS has been shown to modulate aspects of neuronal plasticity such as motor learning and structural reorganisation of neural tissue. However, the impact of low intensity rT...
Article
During mammalian visual system development, retinal ganglion cells (RGCs) undergo extensive apoptotic death. In mouse retina, approximately 50% of RGCs present at birth (postnatal day 0; P0) die by P5, at a time when axons innervate central targets such as the superior colliculus (SC). We examined whether RGCs that make short-range axonal targeting...

Citations

... These pieces of information highlight that BDNF is excessively produced after the onset of target innervation and at the early stages of RGC development. However, adult RGCs are supported by BDNF, which is primarily produced locally (Beros et al., 2021). The enhanced retrograde transport of BDNF is triggered when the local trophic support is progressively interrupted. ...
... Attenuated neuronal death following iTBS was accompanied by a reduction in pro-inflammatory factors and an increase in anti-inflammatory factors. Anti-inflammatory effects of rTMS have been demonstrated in neurological disorders and animal models (Aftanas et al., 2018;Hong et al., 2020;Clarke et al., 2021;Dragić et al., 2021c). Furthermore, rTMS was found to inhibit the polarization of astrocytes toward neurotoxic (A1-like) phenotype (Hong et al., 2020), which are also present in TMT-induced neurodegeneration (Dragić et al., 2021a,b). ...
... Naturally occurring cell death or apoptosis also happens during the first two to three weeks after birth (Cepko et al., 1996;Livesey and Cepko, 2001). Approximately 50% of RGCs present at birth die within the first two postnatal weeks (Beros et al., 2018), and Müller cell degeneration also reaches a peak at postnatal days 8-11 (Young, 1984). In other words, even after birth, the inner retina goes through dramatic changes with neurogenesis, cell death, synaptic maturation, and refinement. ...