James Jackard’s scientific contributions

... Existing computational methods evaluate genome-transcriptome or microbiome-transcriptome associations in isolation, without explicitly modeling the additive effects or GMIs [8][9][10][11]. In multiple regression, interaction terms, which capture the multiplicative effect between two variables, enable the modeling of the dependency where the effect of one variable on the outcome may depend on the value of another variable [12]. The multiplicative interaction terms have been used to represent the interaction between genotype and environment in modeling phenotypes [5,13]. ...

Reference:

Multiomics integration unravels genotype-microbiome interactions shaping the conjunctival transcriptome