Jakob Siemerkus's research while affiliated with ETH Zurich and other places

Publications (14)

Article
Full-text available
Background Independent supported housing (ISH)—services to support independent housing are recommended by current guidelines. However, there is little evidence of ISH models for non-homeless people with severe mental illness (SMI). The aim of this study was to examine the effectiveness of ISH by comparing the clinical outcomes of a newly implemente...
Article
This scientific commentary refers to ‘Acquisition of visual priors and induced hallucinations in chronic schizophrenia’, by Valton et al. (doi:10.1093/brain/awz171).
Article
Objective: This paper investigates the subjective needs of psychiatric patients in relation to the housing conditions with an additional focus on inclusion and participation. Furthermore, it examines differences in clinical and socio-demographic parameters, self-measured quality of life, stage of recovery. Methods: In this quantitative cross-sec...
Poster
Full-text available
Background Present pharmacological treatment approaches in schizophrenia rest on “neuroleptic” drugs, all of which act as antagonists at dopamine D2/D3 receptors but additionally display major variability in their binding capacity to neurotransmitter receptors (Van Os & Kapur 2009). At present, the choice of any particular drug does not rest on any...
Article
Zusammenfassung. Computational Psychiatry (CP) ist ein junges Wissenschaftsfeld an der Schnittstelle zwischen der klinischen Psychiatrie und den mathematischen Neurowissenschaften, das sich in den letzten Jahren zu entfalten begonnen hat. Dieser Artikel widmet sich den moglichen klinischen Implikationen dieser jungen Disziplin. Wir (i) beginnen mit...
Article
Full-text available
Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-s...
Article
Full-text available
In this study, we assessed the relationship of insular strokes and plasma MR-proANP levels with newly diagnosed atrial fibrillation (NDAF). This study is based on a prospective acute stroke cohort (http://www.clinicaltrials.gov, NCT00390962). Patient eligibility was dependent on the diagnosis of acute ischemic stroke, absence of previous stroke bas...
Article
Present neuroimaging findings suggest two subtypes of trauma response, one characterized predominantly by hyperarousal and intrusions, and the other primarily by dissociative symptoms. The neural underpinnings of these two subtypes need to be better defined. Fourteen women with childhood abuse and the current diagnosis of dissociative amnesia or di...
Article
Full-text available
Psychotic symptoms in schizophrenia are related to disturbed self-recognition and to disturbed experience of agency. Possibly, these impairments contribute to first-person large-scale egocentric learning deficits. Sixteen inpatients with schizophrenia and 16 matched healthy comparison subjects underwent functional magnetic resonance imaging (fMRI)...
Article
Longitudinal studies have failed to find progressive hippocampal size reduction in schizophrenia. However, negative results may have been due to follow-up intervals at disease stages where no significant progressive brain changes occur. Furthermore, only male or mixed gender samples have been studied. Forty-six patients with schizophrenia (23 femal...
Article
Background: Present evidence suggests that the hippocampus (HC) and the parahippocampal cortex (PHC) are involved in allocentric (world-centered) spatial memory. However, the putative role of the PHC in egocentric (body-centered) spatial learning has received only limited systematic investigation. Methods: To examine the role of the PHC in egoce...
Article
Full-text available
Shape and exact location of motor cortical areas varies among individuals. The exact knowledge of these locations is crucial for planning of neurosurgical procedures. In this study, we have used robot-assisted image-guided transcranial magnetic stimulation (Ri-TMS) to elicit MEP response recorded for individual muscles and reconstruct functional mo...

Citations

... In our two-centre study on the effectiveness of ISH for non-homeless persons with SMI [32], one centre made a second attempt to conduct an RCT in this field [33], while the other centre conducted an OS with PS methods. Random allocation was possible at one of the two sites due to the new introduction of ISH and the scarcity of comparable services in the region, which allowed limited access of ISH only to study participants [33]. ...
... In recent years, predictive processing models have arguably become the dominant approach to explain hallucinations in SSD. There are many subtypes of predictive processing models that include self-monitoring approaches (Farrer and Franck, 2007;Ford and Hoffman, 2013) and Bayesian approaches (Friston, 2005;Siemerkus et al., 2019). Both approaches maintain that a critical function of our brains is to make accurate predictions; to do this, our brains are on a quest to minimize prediction errors (e.g., mismatches between outcomes we anticipate vs. outcomes we actually perceive). ...
... Dies gilt auch für die Situation in der Schweiz. Die bisherige Forschung hat sich hierzulande überwiegend auf psychiatrische und psychosoziale Merkmale von Menschen in Wohneinrichtungen konzentriert (Gurtner, Hoffmann, & Richter, 2015;Jaeger, Briner, Kawohl, Seifritz, & Baumgartner-Nietlisbach, 2015;Jäger et al., 2014;Jäger, Theodoridou, Hoff, & Rössler, 2013;Wartmann et al., 2019). Daneben existiert eine kleine Forschungsliteratur zur Relevanz der Obdachlosigkeit in der psychiatrischen Versorgung (Lauber, Lay, & Rössler, 2005. ...
... First, generative embedding reduces the dimensionality of data by fitting a generative model with interpretable parameters; this allows representing data from subjects by a small number of features, which can also improve the performance of algorithms. Second, this can provide information about why patients are divided into certain subgroups by a machine learning algorithm, because the features used by the algorithm are mechanistically interpretable [54,56]. ...
... Recently, a meta-analysis study found that almost all major white matter regions were affected in SZs (Kelly et al., 2018). Overall, the dysconnectivity hypothesis in schizophrenia is one of the generally accepted theories at present (Friston et al., 2016). ...
... Early and accurate identification of stroke patients at high risk for AF is important in selecting candidates for intensive cardiac monitoring such as implantable loop recorders. Larger studies are needed to better define the incidence and clinical presentation in IIS [26]. ...
... New generation VR headsets are price-accessible and powerful enough to provide high-resolution stimuli presentation within realistic and interactive 3D environments, providing increased ecological validity, exibility, sensory feedback, and performance recording [40,41] -see Gaggioli [42] for an early review of VR application. In fact, there are many successful examples of the use of VR as an assessment tool for skills related to EF, such as working memory and task-switching [43] , cognitive load in navigation [44] , memory [45] , behavioural responses in eating disorders [46] and, more recently, cognitive function in terms of reasoning and attention switching [47] . ...
... MRI-compatible VR helmets have been developed that are designed to answer the specific needs of VR-fMRI, ensuring immersion in the VE. For instance, among others, Andoh et al. (2020), , Siemerkus et al. (2012), Suthana et al. (2011) and Weniger et al. (2013) reported the use of the head-mounted display by Resonance Technology Inc., respectively with a 3-T Siemens Allegra scanner for Suthana et al. (2011) and a 3-T Siemens Magnetom Trio for Andoh et al. (2020), Siemerkus et al. (2012) and Weniger et al. (2013) and a 3-T Siemens Tim Trio for . Duarte et al. (2014) reported the use of stereoscopic glasses by Avotec Inc. in a 3-T Siemens Magnetom Trio, Salgado-Pineda et al. (2016) fMRI-safe VR glasses developed by VisuaStim Digital, Resonance Technology Inc., used in a 1.5-T scanner (General Electric Medical Systems). ...
... Interaction varied across the studies. All used navigation through the VE (see Fig. 4.3 for examples of existing VE): in a town (Burgess et al., 2001;Hartley et al., 2003;Salgado-Pineda et al., 2016;Suthana et al., 2011), a park (Demanuele et al., 2015;Doeller et al., 2010;Migo et al., 2016;Morgan et al., 2014), a maze Cyr et al., 2016;Iglói et al., 2015;Javadi et al., 2019;Siemerkus et al., 2012;Tau et al., 2014;Weniger et al., 2013;Weniger et al., 2010), a room (Antonova et al., 2011;Duarte et al., 2014;Parslow et al., 2004;Sutton et al., 2010), a corridor (Slobounov et al., 2010), and from one building to the next (Lee et al., 2016). Two studies (Gomez et al., 2014;Wolbers et al., 2004) reported no interaction in the VE, which was explored through videos with fixed points of view. ...
... Sex differences in schizophrenia have been reported in the literature, including the age of onset (Eranti et al., 2013), functional impairment (Thorup et al., 2007), neurocognitive impairment (Kao et al., 2013;Zhang et al., 2017), and social cognition (Andric Petrovic et al., 2019). High resolution MRI has shown sex-differences in BOLD signal in several regions of the brain: cortex (Goldstein et al., 2002), hippocampus (Irle et al., 2011), hypothalamus (Goldstein et al., 2007), and insula (Duggal et al., 2005), as well as grey matter volume asymmetry (Frederikse et al., 2000), the gyrification index (Matsuda and Ohi, 2018), and cortical folding (Narr et al., 2004)) with distinct patterns of change in relation to sex. ...