Jairo Mendez-Rico's research while affiliated with Pan American Health Organization (PAHO) and other places
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Publications (12)
The onset of the COVID-19 pandemic triggered a rapid scale-up in the use of genomic surveillance as a pandemic preparedness and response tool. As a result, the number of countries with in-country SARS-CoV-2 genomic sequencing capability increased by 40% from February 2021 to July 2022. The Global Genomic Surveillance Strategy for Pathogens with Pan...
Background
Viral reactivations and co-infections have been reported among COVID-19 patients. However, studies on the clinical outcomes of different viral reactivations and co-infections are currently in limit. Thus, the primary purpose of this review is to perform an overarching investigation on the cases of latent virus reactivation and co-infecti...
Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and combined with multidisciplinary studies of infectivity, virulence and immune escape, in order to track the unpredictable evolution of the ongoing COVID-19 pandemic.
The timely release of SARS-CoV-2 first genomic sequences allowed the identification of the etiologic agent and development of diagnostic protocols. Genomic sequencing was a crucial step in generating data for driving laboratory response and detections of SARS-CoV-2 since the start of the COVID-19 pandemic. Because of all the progression and achieve...
By the time the etiologic agent of the COVID-19 was identified as a novel coronavirus, no country in the Americas Region had laboratory capacity for detecting this new virus. A strategic multilevel approach with specific reagent purchase and delivery, regional trainings, in-country missions, and the provision of technical support was established fo...
Yellow fever (YF), an arboviral disease, affects an estimated 200,000 people and causes 30,000 deaths per year and recently has caused major epidemics in Africa and South America. Timely and accurate diagnosis of YF is critical for managing outbreaks and implementing vaccination campaigns. A YF immunoglobulin M (IgM) antibody-capture (MAC) enzyme-l...
Objectives: To standardize and validate an in-house RT-LAMP test for the detection of SARS-CoV-2, based on laboratory and field assays using samples from COVID-19 suspected patients. Materials and methods: An in-house SARS-CoV-2 RT-LAMP molecular test was standardized, establishing the detection limit with Vero cells of isolated Peruvian strains of...
Objectives. To measure protocol adherence and antigen-based detection tests (AgDT) negative predictive value after 3 months of massive use as a diagnostic tool for COVID-19 in Guatemala. Methods. The study period included nasopharyngeal swabs taken between March 12 and August 31, 2020, which results were entered in the national COVID-19 information...
A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of the first case-control study evaluating the potential causes of microcephaly: congenital Zika virus infection, vaccines,...
Background:
A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of the first case-control study evaluating the potential causes of microcephaly: congenital Zika virus infecti...
We studied the clinical characteristics for 104 infants born with microcephaly in the delivery hospitals of Pernambuco State, Brazil, during 2015. Testing is ongoing to exclude known infectious causes. However, microcephaly peaked in October and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications...
La elaboración de este “Instrumento para el diagnóstico clínico y la atención a pacientes con sospecha de arbovirosis” estuvo a cargo de médicos clínicos de las Américas, especialistas en la atención de casos de chikungunya y zika, del Grupo Técnico Internacional en dengue (GT-Dengue) y del personal técnico de la Organización Panamericana de la Sal...
Citations
... Its ability to deliver rapid and cost-effective sequencing has the potential to enhance the diagnostic capabilities of these facilities, contributing to more effective surveillance practices and expedited responses to infectious disease threats. Establishing and maintaining genomic surveillance capabilities in resource-limited settings is a complex effort filled with challenges [125,126]. It demands a considerable pool of expertise, encompassing both wet laboratory techniques (such as DNA extraction and sequencing) and dry laboratory skills (including data analysis and interpretation). ...
... In our case, the possibility of keratitis due to Epstein-Barr virus or herpes simpex virus could not be definitively ruled out. Patients with severe COVID-19 infection have impaired immunity characterized by a reduction in the number of CD4 + and CD8 + T cells; reactivation or coinfection with other viruses have been well-documented among COVID-19 patients [23]. Although written clinical records of our patient revealed no prior corneal findings prior to COVID-19, we did not have photographic documentation of healthy corneas. ...
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... Over one million people are newly infected by hand, foot, and mouth disease (HFMD) and hepatitis beta virus (HBV) per year in China [19]. Early warning systems play a pivotal role in managing infectious disease risk [32]. The predictive technique is the foundation of this system [42], which is instrumental in guiding healthcare decision-making processes and devising intervention strategies [8]. ...
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... The characterization of emerging variants as VOCs was initiated in late 2020 [1]. Epidemiological data on virus circulation in South America show that the D614G variant (lineage B.1) was the main circulating SARS-CoV-2 variant during this period [17] until the appearance of the Gamma variant late in 2020. The first sequence registered in Pango for the Gamma variant corresponds to the one reported in Brazil on October 1, 2020, whereas in Paraguay this variant was reported for the first time on January 31, 2021 [18]. ...
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... However, in the Pan American Health Organization (PAHO) region, various countries have expressed, even before the upsurge of the Omicron, their limitations to scale up professional-led mass screening for COVID-19. [6][7][8] In parts of the PAHO region, while having primary healthcare settings dedicated to screening for COVID-19 has been helpful to decrease COVID-19 incidence rates, this approach has also deviated attention and resources away from other conditions such as HIV 9 or rheumatic diseases. 10 Various community-based FTTI approaches have been implemented in Peru. ...
... The coronavirus disease 2019 (COVID- 19) is an acute respiratory syndrome caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded, positive-sense RNA virus belonging to the genus Betacoronavirus of the family Coronaviridae [1]. SARS-CoV-2 is transmitted from person to person through saliva and nasal excretions containing viral particles [2]. ...
... El método de amplificación isotérmica mediada por bucle (LAMP) se caracteriza por realizar una amplificación de manera más rápida y económica en comparación a otras técnicas (42). Requiere una temperatura constante entre 60 -65 Cº y la técnica requiere la utilización de 4 -6 cebadores que permitan la formación de horquillas en las primeras fases de síntesis del ADN (33,43,44). ...
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... ; https://doi.org/10.1101/2023.11.24.23298980 doi: medRxiv preprint infection observed during the 2015 outbreak in Brazil. 10,11 In addition to direct disease effects, pregnant women and their offspring are likely to be impacted by indirect effects, such as decreased access to maternity services, and increased childcare demands on working mothers during lockdown situations. 12,13 In addition, pregnant women are generally excluded from clinical trials of medicines and vaccines, resulting in delayed access to potentially life-saving treatments or preventative interventions. ...
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... Flaviviruses include well-known mosquito-borne pathogens of Public Health concern such as Dengue, Yellow Fever, Japanese encephalitis, or West Nile virus (Pierson & Diamond, 2020;Song et al., 2017). ZIKV was considered a minor concern until 2015 when the Pan-American Health Organization (PAHO) raised the alarm bells when an extensive outbreak in the North-Eastern Brazil was followed by an unexpected incidence of newborns with microcephaly (de Araújo et al., 2018). ZIKV-RNA was then identified from the brain tissue of fetuses exhibiting microcephaly proving the causal relationship between ZIKV exposure during pregnancy and fetal brain damage (Azevedo et al., 2018). ...
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... The researchers of MERG discovered a link between microcephaly and the Zika virus, and hence that the Zika virus causes microcephaly (GROUP, 2016). For leading this "grand challenge", its leader was acknowledged as one of the most renowned scientists in the world (BUTLER, 2016), because as stated by Frieden (2017), "She understood that this was a global crisis requiring global collaboration". ...
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