Jain DK’s research while affiliated with IPS Academy and other places

This study was aimed to fabricate and evaluate a combination of Artemether and Lumefantrine as tablets and to make Artemether in sustained form so as to prolong its elimination time. Artemether was formulated in form of microspheres by solvent evaporation technique and was then formed into the tablet along with the Lumefantrine. Artemether microspheres were prepared and compressed into compressible tablet by direct compression process using the compressible excipients along with Lumefantrine, and was further evaluated for various parameters such as hardness, thickness, weight variation, friability, drug content, in vitro drug release and stability.

Objective: To investigate the in vivo antidiarrheal effect of the ethanolic extract of leaves of Malvastrum tricuspidatum in rats, evaluated by castor oil, magnesium sulphate and charcoal. Methods: The extract was evaluated for activity by three different approaches castor oil–induced diarrhea, castor oil and magnesium sulphate-induced enteropooling and gastrointestinal motility test using charcoal meal. Initially assayed at the doses 100, 250, and 500 mg/kg, p.o. Atropine (5 mg/kg p.o.), Loperamide (3 mg/kg) was used as a standard drug. Result: The 500 mg/kg dose of ethanol extract showed significant (p < 0.05) activity against castor oil–induced diarrhea. Hence, this dose level was selected significantly and used in other models. The extract was found to inhibit intrafluid accumulation in castor oil as well as magnesium sulphate induced enteropooling, also a significant reduction in the gastrointestinal motility in charcoal meal test confirming its antidiarrheal activity. Conclusion: The result support continued investigation of components of ethnomedicinal use of M. tricuspidatum leaves as a valuable natural remedy for the treatment, management and control of diarrhea. Keywords: Malvastrum tricuspidatum, anti-diarrheal activity, castor oil, charcoal, magnesium sulphate, enteropooling.

The present study was performed to substantiate the traditional claim of the wound healing activity of stem bark of Albizzia lebbeck Linn. in rats. The effects of aqueous and ethanolic extracts of stem bark of A. lebbeck (5% and 10% w/v topically and 250 mg/kg and 500 mg/kg p.o.) on excision, incision and dead space wound model were examined. The extracts were administered orally for 10 days for incision and dead space wound model and for excision model drugs were administered until complete epithelialization. The healing of wound was assessed by the rate of wound contraction and period of epithelialization for excision model, tensile strength and histopathology of the incision wound skin for incision model, dry granulation tissue weight and hydroxyproline content for dead space wound. Treatment of wound with ethanolic extract 10% w/v topically exhibited significant (p < 0.01) wound healing activity in all three models as compared to control groups. High rate of wound contraction, decrease in period of epithelialization, high tensile strength, increase in dry granulation tissue weight, elevated hydroxyproline content and increased collagenation in histopathological section were observed in animals treated topically with 10% w/v ethanolic stem bark extract. The ethanolic and aqueous extracts were quantitatively analyzed for alkaloids, flavonoids and phenols, and the contents were found to be greater in ethanolic extract than aqueous extract. Topical application (10% w/v) of ethanolic extract possesses better wound healing property and this activity could be attributed due to presence of alkaloids, phenols and flavonoids.

Abstract Antiulcer potential of ethanolic stem bark extract of A. lebbeck were determined using ethanol induced, aspirin induced, cold stress restraint and pylorus ligated ulcer in rats. The ethanol extract (100, 250, 500, and 1000 mg/kg, p.o.) significantly suppressed the peptic ulcer induced by ethanol. Ethanolic extract (500 mg/kg) showed promising activity. Hence, this dose was selected for the further evaluation of antiulcer studies. The ethanolic extract (500 mg/kg) showed significant (p< 0.05) reduction in gastric volume, free acidity, total acidity, ulcer index, protein and pepsin content and increase in mucus content as compared to control. The present study indicates that A. lebbeck bark extract have potential antiulcer activity in all models which might be due to its antisecretory activity and increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa. Keywords: Albizzia lebbeck, Gastric ulcer, cytoprotection, antisecretory.

The present study was performed to substantiate the traditional claim of the antidiarrheal activity of stem bark extract of Albizzia lebbeck Linn. in rats. The effects of ethanolic extract of the stem bark of A. lebbeck on castor oil-induced diarrhea, castor oil magnesium sulphate-induced enteropooling, and gastrointestinal motility test using charcoal meal method were examined. The extract was initially assayed for its effects in castor oil-induced diarrhea at different doses (250, 500, and 1000 mg/kg, p.o.) in which significant activity (p<0.05) was observed at a dose level of 500 mg/kg. Hence, this dose level was then used in other models. The extract was found to inhibit peristaltic movements in charcoal meal test, and intestinal fluid secretions in castor oil as well as magnesium sulphate induced enteropooling, confirming its antidiarrheal activity, which might be due to its high flavonoid content. The results provide evidence that the ethanolic extract of A. lebbeck stem bark possesses antidiarrheal activity.

The purpose of this study is to discuss the potential of learning style modeling for improving the eLearning experience. Various learning style models emerged over the two decades which has brought increasing attention towards the fact that students learn in diverse ways and one way of teaching or delivering the same content to all students won't work fine. Taking this into consideration, the study identified two ways of improving the efficacy of online education. One method for achieving this is the use of learning styles for personalized course content delivery and the other way focused on identifying the prior knowledge level through assessment for personalized course path. The proposed model for automatic construction of prior knowledge level model aims to connect questions in the assessment to specific course modules in order to identify levels on different modules, because a learner may have varying levels of knowledge within different modules. This paper presents the results of our approach evaluation from the point of learning styles and prior knowledge level.