Jaime A Oviedo's research while affiliated with Boston Medical Center and other places
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Publications (19)
Current evidence suggests that PPIs might be effective in maintaining patients in remission during continued NSAID use and that the combination of omeprazole plus diclofenac is as effective as treatment with celecoxib in preventing recurrent bleeding. Larger outcome studies comparing the combination of a PPI with other nonselective NSAIDs and a sel...
We present the case of a 24-year-old man with recurrent peptic ulcers and hypergastrinemia, in whom a multidisciplinary investigation for gastrinoma revealed a duodenal web. The affected duodenal segment was excised, and a gastroduodenostomy with highly selective vagotomy was performed. Postoperative serum gastrin levels returned to the normal rang...
The American Journal of Gastroenterology (2003) 98, S199; doi:10.1111/j.1572-0241.2003.08337.x
Risk stratification is essential to the appropriate use of colorectal cancer screening recommendations. The principal objective of this study was to assess the knowledge and screening behavior of internal medicine (IM) residents regarding familial colorectal cancer.
We conducted a survey of IM residents in their second and third year of postgraduat...
The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastr...
The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastr...
The management of patients with inflammatory bowel disease (IBD) continues to present a challenge for gastroenterologists. IBD constitutes a significant burden for the affected individual because of both intestinal and systemic manifestations. The lack of a specific cause and a definitive cure for this condition, as well as the potential for associ...
On the basis of their reduced potential to cause injury to the gastroduodenal mucosa, cyclo-oxygenase (COX)-2-selective inhibitors were developed and marketed as a safer alternative to traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This manuscript reviews the major steps leading to the introduction of COX-2-selective inhibitors into cli...
Citations
... Nevertheless, one feature that is often ignored in the drug development process is that drug candidates, whether aimed at modulating inflammation or other processes, may have unforeseen effects in vivo based on their effects on the inflammatory response (e.g. gastrointestinal toxicity of cyclooxygenase-2 inhibitors [2,3]. Cyclooxygenase (COX) or prostaglandin (PG) H synthase, is the key enzyme in inflammation scenario. ...
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... Moreover, GX has a typical endoscopic appearance of yellow-white, well-marked single or multiple nodules or plaques, ranging in diameter from 1 to 10 mm [15]. Endoscopy magnification with narrow-band imaging is commonly used in the identification of gastric xanthoma because this method can have the image magnified to see it very clearly. ...
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... Unlike other lifestyle therapies such as smoking cessation, there is a lack of clear evidencebased literature that focuses on using diet manipulation, PA/E, and psychological interventions in IBD [2,7] . The concern is that selfsought CAM may lack an evidencebase or health professionals may fail to make recommendations about CAM leaving patients frustrated [2,15] . Clear evidencebased guidance to patients and health professionals on CAM would alleviate this problem. ...
... Although studies exist that support the safe use of APAP up to 4 g taken oncedaily for 2 days in patients given alcohol (in whom no elevated liver enzymes were seen), 136 others have pointed to the limitations of this study and do not believe that it proves the absence of any hepatotoxic risk. 137 Seifert and Anderson 138 reported that daily alcohol drinkers were more than twice as likely as nondrinkers to be regular users of APAP (29% vs. 12%), or abusers of APAP (36% vs. 15%). Those with elevated GGT levels had significantly lower plasma glutathione concentrations, a clinical marker of depleted GSH in alcoholics and a risk factor for APAP liver injury. ...
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... En el caso de telangiectasias gastrointestinales sangrantes accesibles, el tratamiento endoscópico con gas argón es el de elección, dada su facilidad de uso, eficacia y seguridad. El tratamiento farmacológico concomitante con fármacos estimuladores de la producción de endoglina o antiangiogénica como el bevacizumab no están recomendados en la actualidad [249][250][251][252] . ...
... Earlier studies indicated low level of adherence to guidelines among US-based Internal Medicine (IM) residents. 23 One of the main factors for this may be that programs do not offer curricula which aims at teaching residents on how to use guidelines. For example, a survey of 434 IM and family practice programs found that only 14% reported providing written goals aimed at teaching guidelines to trainees. ...
... Various endoscopic approaches for the treatment of EST bleeding have been reported, including injection therapy with HSE [24], balloon compression [25], argon plasma coagulation [26], and hemoclip [27]. Although post-EST bleeding is not associated with increased mortality and morbidity rates, length of hospital stay as well as costs may increase [2]. ...
... 19 Other approaches to protect patients from GI complications using traditional NSAIDs in combination with misoprostil, H2-receptor blockade, or proton pump inhibitors (PPIs) are also effective. 20,21 Renal Both COX-1 and COX-2 are expressed in adult kidney tissues 22 and inhibition of these enzymes by NSAIDs is well-known to affect sodium and water handling, and to reduce glomerular filtration rate (GFR). This is also true for celecoxib. ...
Reference: Celecoxib in the Treatment of Osteoarthritis
... Менее частой причиной ОП у паци ентов с ВЗК, чем среди популяции в целом, является употребление алкоголя [36]. [78] или возможного рефлюкса содержимого двенадца типерстной кишки в проток ПЖ изза повышения внутридуоденального давления [1]. Дуоденопанк реатический свищ -крайне редкое осложнение поражения двенадцатиперстной кишки при БК, которое способствует развитию ОП [40]. ...
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... selective NSAIDs found the composite incidence of myocardial infarction, stroke and cardiovascular death was decreased by celecoxib when compared with all NSAIDs (OR 0.81, 95% CI 0.66 to 0.99) and selective NSAIDs (OR 0.56, 95% CI 0.40 to 0.77).51 This may be attributed to the observations that the increased incidence of cardiovascular and cardiorenal events associated with the use of COX-2 inhibitors only becomes apparent after between 12 and 18 months of continuous treatment.52,53 Non-selective NSAIDs vs selective NSAIDs. ...
