Jacqueline Pelet’s research while affiliated with University of Lausanne and other places

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Publications (4)


[Estimation of glomerular filtration rate by the formula GFR = K x T/Pc]
  • Article

March 1999

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79 Reads

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9 Citations

Archives de Pédiatrie

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J Pelet

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Creatinine clearance is the most common method used to assess glomerular filtration rate (GFR). In children, GFR can also be estimated without urine collection, using the formula GFR (mL/min x 1.73 m2) = K x height [cm]/Pcr [mumol/L]), where Pcr represents the plasma creatinine concentration. K is usually calculated using creatinine clearance (Ccr) as an index of GFR. The aim of the present study was to evaluate the reliability of the formula, using the standard UV/P inulin clearance to calculate K. Clearance data obtained in 200 patients (1 month to 23 years) during the years 1988-1994 were used to calculate the factor K as a function of age. Forty-four additional patients were studied prospectively in conditions of either hydropenia or water diuresis in order to evaluate the possible variation of K as a function of urine flow rate. When GFR was estimated by the standard inulin clearance, the calculated values of K was 39 (infants less than 6 months), 44 (1-2 years) and 47 (2-12 years). The correlation between the values of GFR, as estimated by the formula, and the values measured by the standard clearance of inulin was highly significant; the scatter of individual values was however substantial. When K was calculated using Ccr, the formula overestimated Cin at all urine flow rates. When calculated from Ccr, K varied as a function of urine flow rate (K = 50 at urine flow rates of 3.5 and K = 64 at urine flow rates of 8.5 mL/min x 1.73 m2). When calculated from Cin, in the same conditions, K remained constant with a value of 50. The formula GFR = K x H/Pcr can be used to estimate GFR. The scatter of values precludes however the use of the formula to estimate GFR in pathophysiological studies. The formula should only be used when K is calculated from Cin, and the plasma creatinine concentration is measured in well defined conditions of hydration.


Estimation of glomerular filtration rate by the formula K × T / P cr

February 1999

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45 Reads

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17 Citations

Archives de Pédiatrie

Background. Creatinine clearance is the most common method used to assess glomerular filtration rate (GFR). In children, GFR can also be estimated without urine collection, using the formula GFR (mL/min × 1.73m2) = K × height cm/ mmol/L), where Per represents the plasma creatinine concentration. K is usually calculated using creatinine clearance (Ccr) as an index of GFR. The aim of the present study was to evaluate the reliability of the formula, using the standard UV/P inulin clearance to calculate K. Methods. Clearance data obtained in 200 patients (I month to 23 years) during the years 1988–1994 were used to calculate the factor K as a junction of age. Forty-four additional patients were studied prospectively in conditions of either hydropenia or water diuresis in order to evaluate the possible variation of K as a function of urine flow rate. Results. When GFR was estimated by the standard inulin clearance, the calculated values of K was 39 (infants less than 6 months), 44 (1–2 years) and 47 (2–12 years). The correlation between the values of GFR, as estimated by the formula, and the values measured by the standard clearance of inulin was highly significant; the scatter of individual values was however substantial. When K was calculated using Ccr, the formula overestimated Cin at all urine flow rates. When calculated from Ccr, K varied as a function of urine flow rate (K = 50 at urine flow rates of 3.5 and K = 64 at urine flow rates of 8.5 mL/min × 1.73m2). When calculated from Cin, in the same conditions, K remained constant with a value of 50. Conclusions. The formula GFR = K × H/Pcr can be used to estimate GFR. The scatter of values precludes however the use of the formula to estimate GFR in pathophysiological studies. The formula should only be used when K is calculated from Cin, and the plasma creatinine concentration is measured in well defined conditions of hydration.


Long-term followup of renal functional reserve capacity after unilateral nephrectomy in childhood

October 1998

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17 Reads

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45 Citations

The Journal of Urology

Bianca M. Regazzoni

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Noel Genton

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Jacqueline Pelet

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[...]

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We establish renal function and renal reserve capacity in the long-term followup of unilateral nephrectomy in childhood. We recalled 37 subjects who underwent unilateral nephrectomy during childhood (age less than 16 years) to determine glomerular filtration rate, renal plasma flow and functional renal reserve capacity after oral protein loading. Interval since nephrectomy was 0.5 to 10 years in 10 cases, 11 to 20 in 13 and more than 20 years in 14, during which regular repeated renal function tests were done at our hospital. None of the patients had hypertension or significant proteinuria and all developed normally into adults. A group of 7 healthy normal subjects with 2 kidneys served as controls. Creatinine clearance increased 34% immediately after surgery from a mean plus or minus standard error value of 78.6 +/- 6 to 105.4 +/- 7.2 ml. per minute per 1.73 m.2, peaked 2 to 6 months postoperatively and then plateaued (approximately 125 ml. per minute per 1.73 m.2). This level of renal function was sustained for more than 20 years. At the present testing glomerular filtration rate and renal plasma flow were not different from those of the controls. Renal reserve capacity was normal (stable) only during the first decade after unilateral nephrectomy (approximately 6% decrease), and it decreased by 50% at 10 to 20 and 66% at 20 to 30 years later. This long-term followup study demonstrates that a single remnant human kidney continues to function normally for more than 20 years. The prolonged increased workload does not interfere with normal development and maturation. The renal reserve capacity decreased significantly during the years may, however, indicate a vulnerability of the single kidney and raises the possibility of renal functional impairment with much longer followup.


Citations (3)


... Because the kidneys do not control fluid homeostasis before birth, nephrogenesis and renal growth are not regulated by physiologic requirements during fetal life, when the development of glomerulus, tubules, and the renal collecting system is under the control of genetic, environmental, hormonal, nutritional, and growth factors [1]. During gestation, glomerular filtration rate (GFR) increases in parallel with gestational age up to the end of nephrogenesis, which is achieved by [35][36] weeks of gestation. In case of preterm birth, nephrogenesis continues for up to 40 days of post-natal life, but only in the absence of a renal stress. ...

Reference:

Maturation of glomerular filtration rate in neonates and infants: an overview
Estimation of glomerular filtration rate by the formula K × T / P cr
  • Citing Article
  • February 1999

Archives de Pédiatrie

... However, the GFR during the PLT and the reserve function of the obstructed kidneys gradually decreased and were sometimes even lost from weeks 6 to 12. Thus, the further change in obstructive renal function is essentially a progressive impairment of the reserve function. This is similar to the changing tendency of an unresected kidney's baseline and reserve functions after a single nephrectomy (26). The present study demonstrated that the stability of the baseline GFR after the partial ureteral obstruction was maintained for a certain period by gradually depleted renal reserve function. ...

Long-term followup of renal functional reserve capacity after unilateral nephrectomy in childhood
  • Citing Article
  • October 1998

The Journal of Urology

... Our k-value is different from proposed k-values in older children with CKD 45 and in children with different states of hydration. 46 This highlights the importance of k-value determination in different subpopulations. ...

[Estimation of glomerular filtration rate by the formula GFR = K x T/Pc]
  • Citing Article
  • March 1999

Archives de Pédiatrie