Jacek Szmeja's research while affiliated with Poznan University of Medical Sciences and other places
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Publications (36)
Introduction:
The stoma reversal (SR) procedure is associated with a relatively high risk of perioperative complications with surgical site infection (SSI) as the most common. Recently closed incision negative pressure wound therapy (ciNPWT) was applied widely to prevent SSI.
Aim:
To investigate the efficiency of ciNPWT in terms of the incidence...
AIM
To determine tissue expression (mRNA, protein) of two types of mucins [mucin 1 (MUC1) and mucin 2 (MUC2)] in patients with colorectal cancer (CRC).
METHODS
Expression of membrane-bound mucin (MUC1) and secretory mucin (MUC2) in CRC (mRNA, protein) were analyzed in tissue material including fragments of tumors obtained from CRC patients (n = 34...
A patient had intestinal obstruction due to a rare cause. The patient presented unusual signs and symptoms. Although we performed a thorough diagnostic workup (CT, ultrasound, radiography, endoscopy), only laparotomy revealed that a bezoar caused the intestinal obstruction. The bezoar consisted of a herbal preparation, which was mentioned by the pa...
Purpose:
The purpose of this study was to determine the effect of a conservative regimen for the treatment of constipation in persons living with a colostomy.
Design:
Prospective, noncontrolled, single-center study.
Subjects and setting:
The study sample comprised 35 patients with a colostomy who were diagnosed with constipation. Subjects with...
PurposeBiofragmentable anastomosis ring (BAR) is an alternative to manual and stapled anastomoses performed within the upper and lower gastrointestinal (GI) tract. The aim of this study was to evaluate the effectiveness of BAR utility for bowel anastomoses based on our own material. MethodsA retrospective analysis was performed to a total of 203 pa...
To evaluate the expression of different insulin-like growth factor (IGF)-1 mRNA isoforms and IGF-1 receptor (IGF-1R) mRNA in hepatitis C virus (HCV)-infected livers.
Thirty-four liver biopsy specimens from chronic hepatitis C (CH-C) patients were obtained before anti-viral therapy. Inflammatory activity (grading) and advancement of fibrosis (stagin...
The study aimed at quantitative analysis of expression involving markers of mast cells (tryptase), monocytes/macrophages (CD68 molecule) and dendritic cells (S100 protein) in gallbladder mucosa with acute and chronic calculous cholecystitis. Routinely prepared tissue material from the patients with acute (ACC) (n = 16) and chronic calculous cholecy...
Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6,...
Proctocolectomy with ileal pouch-anal anastomosis (IPAA) was performed in ulcerative colitis (UC) for emergent or urgent indications in three stages. Since the three-step procedure imposes enormous demands on a patient, there was an attempt to introduce primary IPAA for urgent indications. The aim of this study was to compare early complications af...
The authors present a case of 58 years old woman suffering from complex pelvic floor pathology diagnosed with rectal prolapse, genitary organs prolapse, descending pelvic floor, rectocele and enterocele as well as advanced diverticular disease of the left colon. She suffered from chronic constipation. The surgery consisted of left hemicolectomy, hy...
The authors present a patient suffering from malignant peritoneal mesothelioma. Differential diagnosis has become the major concern in the fatally ill patient. Pain, increasing abdominal girth, anorexia and weight loss, and recurrent ascites are the most frequent presenting symptoms. In this patient, fever of unknown origin was a clinical mask of m...
The authors present a 32-year-old male patient with incarceration of a recurrent esophageal hiatal hernia after laparoscopic repair. A life-threatening strangulation of the stomach and the transverse colon occurred within a few days after the operation. Relapse of hiatal hernias amounts to almost half of early complications characteristic for the l...
The insulin-like growth factor (IGF)-1 gene consists of 6 exons resulting in the expression of 6 variant forms of mRNA (IA, IB, IC, IIA, IIB and IIC) due to an alternative splicing. The mechanisms of IGF-1 gene splicing and the role of local expression manifested by IGF-1 mRNA variants in colorectal carcinoma (CRC) have not been extensively investi...
Several epidemiological studies have attempted to demonstrate a relationship between increased serum level of insulin-like growth factor 1 (IGF-1) and an augmented risk of developing colorectal cancers (CRC). The human IGF-1 gene is composed of 6 exons and demonstrated expression of 6 different splice variants (isoforms) of mRNA (IA, IB, IC, IIA, I...
Hemangioma is the most common primary tumor of the spine. Pregnancy is a risk factor increasing the possibility of disclosure or exacerbation of symptoms of spinal hemangioma. This paper presents a case of 32-year-old woman with hemangioma of Th6 vertebrae, which was revealed by paresis of the lower limbs and sphincters dysfunction at 34 weeks gest...
Splenic artery aneurysm is the most common aneurysm of visceral vessels. Their rupture usually leads to massive bleeding, being a direct life threat. Splenic artery aneurysms usually rupture into the free peritoneal cavity, and much less frequently into the lumen of the gastrointestinal tract.
We describe the case of a 38-year-old male patient, who...
Cytokeratins (CKs) 8 and 18 are normally expressed in simple epithelia. This unique pair of CKs is believed to be involved in hepatic diseases and many human cancers. Little is known about the role of tissue expression of both CKs in patients with cholelithiasis (CH). The aim of the study was to analyse tissue expression of CK8 and 18 in the specim...
Vacuum-assisted closure (VAC) therapy is a widely acknowledged method for chronic and traumatic wound healing. The feasibility of VAC therapy used for the treatment of intestinal fistulas is still a subject of debate. Complex postoperative wounds pose significant therapeutic problems, especially when there are several fistula openings in the wound...
Background: The authors present a patient who developed adenocarcinoma within the ileal "J" pouch-anal anastomosis (IPAA) after restorative proctocolectomy for familial adenomatous polyposis (FAP). Case report: The patient was treated for recurrent adenomatous polyps within the ileoanal anastomosis. Regular examination of the patient with endoscopi...
Dysplasia of the pouch mucosa after restorative proctocolectomy is rare. The aim of this study was to establish whether there is a correlation between pouchitis and dysplasia.
A group of 276 patients treated for ulcerative colitis by restorative proctocolectomy between 1984 and 2009 was analysed. The presence or absence of pouchitis and dysplasia w...
Restorative proctocolectomy is considered a surgical treatment of choice in ulcerative colitis (UC) and familial adenomatous polyposis (FAP).The aim of the study was to evaluate postoperative complications in patients who underwent surgery for familial adenomatous polyposis and ulcerative colitis, on the basis of a retrospective data analysis.
Data...
The authors presented a rare case of lymphatic angioma of mesentery of the small intestine. The patient underwent successful surgery. The study presents clinical symptoms, diagnostic and therapeutic problems in patients with lymphatic angiomas.
The authors present a 25-year-old female patient who underwent laparotomy for emergent indications due to acute peritonitis in the course of septic cystic transverse mesocolonic lymphangioma. Such a lesion can be classified as a benign neoplasm or as a congenital anomaly. These tumours are more prevalent in children, with a male preponderance. They...
Giant "invasive" schwannomas of the spine occur occasionally, most frequently in the lumbar region. We present the case of a 46-year-old woman with giant "invasive" schwannoma of the lumbar spine, with a 12-year history of illness. The tu-mour originated in the vertebral canal and passed through the paraspinal muscles and retroperitoneal area to th...
Pancreatic cancer is the thirteen leading most common malignancy, accounting for up to 2% of all malignancies. In majority of cases pancreatic cancer is diagnosed when local progression of the malignancy makes radical surgical treatment impossible. The extent of surgical treatment of tumors of the pancreatic head is planned on the basis of preopera...
Recent decades have seen a constant rise in the incidence of IBD in both adults and children. Despite considerable progress in the pharmacological treatment of this disease, surgery has become the more frequently used treatment modality in younger patients. In the presence of massive haemorrhage, free perforation, fulminate colitis or acute obstruc...
The main aim of the study was to evaluate the role of preoperative assays of serum tumour markers in establishing postoperative prognosis in patients with colorectal cancer and to develop a prognostic classification which might be useful in planning treatment strategies. The studies were performed on 350 patients (159 females and 191 males) treated...
The aim of this study was an estimation of the usefulness of histochemical methods using lectins to prognose the postoperative course of colorectal cancer and to plan a mode of treatment. In 300 patients (129 women and 171 men) surgical treatment was performed due to colorectal cancer. The patients ages ranged from 28 to 82 years. Patients survived...
During the years 1989 to 1994, in the Department of General Surgery we performed surgery on 800 cases of large bowel cancer. The cases comprised 412 men (51.5%) and 388 women (48.5%), aged 25 to 85, the most numerous age group ranging from 50 to 70 (60%). Radical surgery was carried out on 501 cases (62.7%) and palliative surgery on 299 cases (37.3...
The aim of the study was to evaluate the results of surgical treatment of colorectal cancer during 45 years of existence of the Department. In this time 1478 cases of rectal cancer and 1008 cases of colon cancer were operated on. Most commonly the diseases occurred between the sixth and seventh decade of live (32.8%). Histology revealed tubular ade...
Blood serum concentrations of CA 19.9, CEA and AFP were measured in 60 patients subjected to surgical treatment for gallbladder carcinoma. The diagnosis was established on the basis of clinical symptoms and histopathological findings in the surgical specimens. 60 gallbladder carcinoma specimens were also immunohistochemically examined for the prese...
Citations
... 10 We made different methodological choices resulting in the exclusion of ten RCTs 59-68 that were included by the Cochrane Review. 10 Eighteen RCTs 33,[37][38][39][40][41][42][43][44][45][46]48,50,[52][53][54][55]57 were not yet included in any of the previous published meta-analyses (Appendix 2). Metaanalysis showed a reduction of SSI rate with iNPWT compared with standard dressings (RR 0.67; 95% CI: 0.59-0.76, ...
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... Our immunohistochemistry results agree with previous studies suggesting that increased expression of Mucin2 is considered a marker for mucinous colon cancer, a subtype of colon cancer [22,[36][37][38]. Our results documenting a decrease or complete loss of Mucin2 in non-mucinous adenocarcinoma of the colon also agree with studies showing that low levels of Mucin2 correlate with colon cancer progression [16,[39][40][41]. ...
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... The PGA BAR will be disintegrated and excreted after healing of the connected intestine, which reduces the risk of inflammation. [4][5][6] However, it is difficult to insert the bulky anastomosis ring into the slippery and collapsed intestine during the surgery, especially when one side is fixed. ...
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... Both the patient and surgeon observe how the stoma is stenosing over time. The management begins with the modification of the diet to make the feces softer since there is difficulty in evacuating the feces, and their flatus even becomes louder; complete obstruction is rare because the stenosis is treated before this happens [6,7]. ...
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... There were no operative complications. At a mean of 16 days (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), the paired magnets were released from the anastomotic site into the intestinal lumen; expulsion occurred at a mean of 24.5 days (17-33) (Fig. 3). ...
... We should differentiate them from other solid tumors which may be present in this location: lipomas, fibromyomas, leiomyomas, xanthogranulomas, neurofibromas and their malignant derivatives [1,3,4,6,7]. They may also simulate lymphoma, lymphangioma, metastatic disease, or soft-tissue sarcoma [9]. ...
... Several clinical studies have shown that the levels of IGF-1 serum concentrations were significantly lower in HCV-associated HCC than in healthy subjects [34,35], the detected low serum IGF-1 level may be attributed to the effect of damage to the liver parenchyma, where the IGF ligands are produced [36,37]. On the other hand, other studies documented upregulation of IGF levels in HCV and HCC patients as compared to the control [38]. Consistent with the result of the current study, we found upregulation of serum IGF-1 in HCV and HCV patients with HCC as compared with healthy individuals and higher levels of IGF-1 in the HCV+HCC group than in HCV patients. ...
... detecting of early-stage of PC [6]. In addition, the common use of fine needle biopsy in the differentiation between malignant and benign changes in pancreas may provide false negative results [6][7][8]. Therefore, novel methods of PC diagnosis and prognosis are critically needed in routine practice. ...
... This may cause changes in intestinal functions and lead to systemic diseases in advanced cases. Acute and chronic cholecystitis in the context of cellular immune response was considered by Kasprzak et al. [24]. Their study was to research the quantitative analysis of expressions with the markers of mast cells (tryptase), monocytes / macrophages (CD68 molecule) and dendritic cells (protein S100) in mucous tissue of the gallbladder in patients with acute and chronic cholecystitis. ...
... BLM p.Leu60Ile was recorded as having conflicting interpretations of pathogenicity in the ClinVar database without clinical information. MSH2 p.Met688Ile was recorded with uncertain significance in the ClinVar database and reported in colorectal cancer, endometrial cancer, and Lynch syndrome [29][30][31][32] . RET p.Glu632Lys was recorded with uncertain significance in the ClinVar database and reported in medullary thyroid carcinoma 33,34 , Hirschsprung's disease 35 , esophageal cancer 36 , colorectal cancer 37 and sporadic pheochromocytoma 38 . ...
