Jaanika Kumm's research while affiliated with University of Tartu and other places

Publications (39)

Article
Full-text available
The objective of this study was to investigate the dynamics of the urinary collagen type II C-terminal cleavage neoepitope (uC2C) before and after total knee replacement (TKR) in rapid knee OA progressors. C2C in the urine was measured by IBEX-uC2C assay in 86 patients (mean age: 59.9 years) with symptomatic knee OA (kOA) undergoing TKR, assessed b...
Article
Objective To assess which structural abnormalities on knee MRI are associated with development of osteophytes in middle-aged subjects without radiographic knee osteoarthritis. Design We included subjects from the Osteoarthritis Initiative, aged 40-55 years, Kellgren & Lawrence grade 0 in both knees, and knee MRIs from both knees available at basel...
Article
Full-text available
Objectives: To assess the long-term effects of arthroscopic partial meniscectomy (APM) on the development of radiographic knee osteoarthritis, and on knee symptoms and function, at 5 years follow-up. Design: Multicentre, randomised, participant- and outcome assessor-blinded, placebo-surgery controlled trial. Setting: Orthopaedic departments in fi...
Article
Full-text available
Objectives To assess the long-term effects of arthroscopic partial meniscectomy (APM) on the development of radiographic knee osteoarthritis, and on knee symptoms and function, at 5 years follow-up. Design Multicentre, randomised, participant- and outcome assessor-blinded, placebo-surgery controlled trial. Setting Orthopaedic departments in five...
Article
Full-text available
Aim To explore whether MRI features suggestive of knee OA are associated with presence of knee pain in possible early‐stage OA development. Methods We included 294 participants from the Osteoarthritis Initiative (mean [SD] age 50 (3) years, 50% women), with baseline Kellgren and Lawrence grade=0 in both knees, and who had all obtained knee MRIs fr...
Article
Aim: To study the development of early knee osteoarthritis (OA) in subjects with and without risk factors for knee OA. Methods: We studied 340 subjects from the Osteoarthritis Initiative, aged 45-55 years (51% women), free of radiographic knee OA at baseline (n=294 with and n=46 without knee pain and other OA risk factors). At baseline, 24, 48,...
Article
Full-text available
Background and purpose — Few data are available regarding structural changes present in knees without radiographically evident osteoarthritis (OA). We evaluated the prevalence of findings suggestive of knee OA by magnetic resonance imaging (MRI) in middle-aged subjects without radiographic OA with or without OA risk factors. Patients and methods —...
Article
Objective: To determine risk factors associated with increased meniscal body extrusion on knee magnetic resonance (MR) images in subjects free of radiographic osteoarthritis. Methods: We selected 340 subjects (aged 45-55 years, mean [SD] body mass index 26.7 [4.4], 51% women) with Kellgren Lawrence grade 0 in both knees and bilateral knee MR ima...
Article
Full-text available
Purpose: To assess the natural history of intrameniscal signal intensity on magnetic resonance (MR) images of the medial compartment. Materials and methods: Both knees of 269 participants (55% women, aged 45-55 years) in the Osteoarthritis Initiative without radiographic knee osteoarthritis (OA) and without medial meniscal tear at baseline were...
Article
Biomarkers are required to detect early OA for intervention and to monitor disease progression. A collagen type II neoepitope C2C was developed for these purposes. The aims of the study to test: i) the biomarker’s ability to differentiate osteo-arthritis (OA) patients with and without structural changes and ii) possible contribution of progression...
Article
Objective: To investigate the possible association between ADAM12 (disintegrin and metalloproteinase domain12) expression in the synovium and the histological synovitis of patients with radiographic knee osteoarthritis (rKOA). Methods: The synovial biopsy samples were harvested from 44 subjects with chronic knee complaints during arthroscopy. In...
Article
Objective: To determine the value of bone markers in early-stage progressive knee osteoarthritis (OA), a population-based cohort of middle-aged subjects with chronic knee complaints was followed over 6 years (two consecutive two 3-year periods). Methods: Tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age...
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Full-text available
Objectives. To investigate associations of selected single-nucleotide polymorphisms (SNPs) in ADAM12 gene with radiographic knee osteoarthritis (rKOA) in Estonian population. Methods. The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 438 subjects (303 women) from population-based cohort, aged 32 to 57 (mean 45...
Article
To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age at baseline, 45 ± 6.2...
Article
Full-text available
Details of the development of early knee osteoarthritis (OA) are largely unknown. The prevalence and progression of radiographic knee OA over 6 years in middle-aged subjects with chronic knee pain is investigated. In a prospective population-based study, tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects (mean age 45...
Article
ADAM12 (A disintegrin and metalloprotease) is one of the candidate genes demonstrating susceptibility to osteoarthritis. The purpose of this study was to investigate the relationship between ADAM12-S protein and radiographic knee osteoarthritis (KOA) and its correlation to several bone and cartilage biomarkers. The ADAM12-S protein was measured in...
Article
Blood biomarkers are subject to pre-analytical variability. In many cases, the stability of important new tissue biomarkers during freeze cycles and storage has not been studied sufficiently. To test the stability of matrix metalloproteinases-7 (MMP-7) and their tissue inhibitors (TIMP-1), vascular growth factors (VEGF) and VEGF-receptor, serum sam...
Article
Little is known regarding the association between ultrasonographic (US) findings and biomarkers of bone and cartilage in individuals with knee osteoarthritis (OA). We investigated (1) US findings in early-stage knee OA and (2) the association between US findings and bone/cartilage biomarkers. A population cohort aged 35-55 years (n = 106) with earl...
Article
Serum osteocalcin (S-OC) is widely used as an index of bone formation. However, there is evidence that some urinary fragments of OC reflect resorption and might be useful in monitoring antiresorptive therapy. Here, we report 6-month changes in urinary midfragments of osteocalcin (U-MidOC) and other bone turnover markers in response to risedronate t...

Citations

... In patients with symptomatic osteoarthritis, meniscal damage is also found very frequently with a prevalence of up to 91% (Bhattacharyya et al., 2003). Meniscal tears are usually caused by trauma and degeneration (Beaufils and Pujol, 2017) and might lead to a loss of function, early osteoarthritis, tibiofemoral osteophytes, and cartilage loss (Ding et al., 2007;Snoeker et al., 2021). Magnetic Resonance Imaging (MRI) is commonly used for the noninvasive assessment of meniscal morphology since MRI provides a three-dimensional view of the knee joint with high contrast between soft tissues. ...
... Currently, a large number of literature have reported that APM was not supported to be applied in first-line treatment of patients with DMMLs [16][17][18]. Sihvonen et al. [18] performed APM on 70 patients with DMMLs and found that Lysholm score showed statistically significant difference in improvement compared with the preoperative condition, but APM did not improve knee symptoms or function better than the arthroscopic surgery group and showed no statistically significant difference. Furthermore, APM was associated with a slightly increased risk of knee osteoarthritis within 5 years after surgery. ...
... The Finnish Degenerative Meniscal Lesion Study (FIDELITY) trial-a randomized trial comparing APM with sham surgery-found greater progression of Kellgren-Lawrence (KL) and Osteoarthritis Research Society International osteophyte grades at 5 years in participants undergoing surgery. 16 We are not aware of studies that have compared the JSW of persons with OA and a meniscal tear who had APM with those with OA and a meniscal tear who did not have APM and with those with OA and no tear. Such data would help define the risk of joint space narrowing (JSN) associated with a meniscal tear and with a tear treated by APM. ...
... Zhu used MRI-defined osteophytes as an endpoint for early development of KOA [11]. The size and number of osteophytes correlated to the intensity of knee pain [12,13]. Because osteophytes increase in size and number in a unidirectional manner and often form prior to symptomatic OA [14,15], they can be used as a predictive biomarker for KOA beyond their diagnostic and assessment value. ...
... Considering that OA changes increase with age and the rate of aging differs individually, the number of osteophytes might simply be correlated to the biological age of the individual. Structural changes of the knee are common irrespective of the presence of pain or other OA risk factors making it difficult to discriminate aging from pathological changes [23]. A future study could mass screen knees of middle-aged people to determine their risk of OA development. ...
... Initially, the Outerbridge classification was established to assess the degree of patellar cartilage lesions. In the current study, the Outerbridge classification was used because Kumm et al. [31] reported, when they examined the distribution of pathology in their knee MRI study, that cartilage lesions were more commonly seen in the patellar cartilage. ...
... Meniscal injury, which is very common among middle-aged and older people, is one of the most important risk factors for the onset and development of knee osteoarthritis (OA). 81 Meniscal degeneration implies breakdown of collagen fibers in the meniscus due to a multifactorial process involving overload, overuse, and failure of biological repair. Although meniscal damage and degeneration are predisposing factors for extrusion, 8 female sex, high body mass index (BMI), varus mechanical axis angle, and lower sports activity level are risk factors for posterior horn root tears. ...
... Recently, a new sandwich assay for human urinary collagen type II C-terminal cleavage neoepitope (uC2C) was developed and its potential for the diagnosis and prediction of knee OA worsening was investigated [6,7]. Highly significant correlations of increased uC2C concentrations with knee complaints and decreased lower-limb functional ability have been detected [8]. ...
... Degenerative meniscus lesions (DMLs) are defined as meniscus lesions that occur without a history of knee trauma in patients older than 35 years [13]. DMLs develop slowly and typically involve a horizontal cleavage [32]. MRI can identify a linear intra-meniscus signal communicating with the articular surface in elderly people; this phenomenon is considered a degenerative process. ...
... Thus, high levels of uC2C could help us to estimate the structural status of the knee in the preoperative period. However, we must not forget that one of the factors influencing uC2C levels is the severity of kOA, as assessed by X-ray [30,50]. Improvement in quality of life and knee function is common after TKR. ...