September 2012
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65 Reads
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16 Citations
The American Journal of Human Genetics
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Publications (11)
November 2011
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21 Reads
Nature Reviews Cancer
We thank Eric Vermeulen and colleagues for their recent correspondence in which they express their concerns about the Bio-PIN system that we described in our article (The Bio-PIN: a concept to improve biobanking. Nature Rev. Cancer 11, 303–308 (2011)
April 2011
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45 Reads
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2 Citations
Nature
March 2011
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583 Reads
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31 Citations
Nature Reviews Cancer
A new biobanking method is proposed, wherein samples and associated data would be deposited anonymously and labelled using a PIN code that is produced on the basis of personal biological characteristics, such as single nucleotide polymorphisms. The code would be the 'Bio-PIN' to uniquely distinguish the sample depositors, plus their samples and data. This method could help to diminish several long-discussed ethical, legal and societal problems in biobanking regarding privacy, informed consent, autonomy, data security and public trust.
May 2010
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24 Reads
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5 Citations
Obstetrics and Gynecology
January 2010
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7 Reads
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1 Citation
Cytotherapy
November 2008
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18 Reads
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10 Citations
Nature Reviews Cancer
The recent Perspective by Sullivan (Sullivan, M. J. Banking on cord blood stem cells. Nature Rev. Cancer 8, 555–563 (2008)
July 2008
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294 Reads
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9 Citations
Biology of Blood and Marrow Transplantation
April 2008
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159 Reads
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66 Citations
Biology of Blood and Marrow Transplantation
Healthcare policies regarding hematopoietic stem cell transplantation (HSCT) must address the need for the procedure as well as the availability of stem cell sources: bone marrow, peripheral blood, or umbilical cord blood (UCB). However, data with respect to the lifetime probability of undergoing HSCT are lacking. This study was undertaken to estimate the latter probability in the United States (U.S.), depending on age, sex, and race. We used data from the Center for International Blood and Marrow Transplant Research, the U.S. Surveillance, Epidemiology and End Results Program, and the U.S. Census Bureau and calculated probabilities as cumulative incidences. Several scenarios were considered: assuming current indications for autologous and allogeneic HSCT, assuming universal donor availability, and assuming broadening of HSCT use in hematologic malignancies. Incidences of diseases treated with HSCT and of HSCTs performed increase with age, rising strongly after age 40. Among individuals older than 40, incidences are higher for men than for women. The lifetime probabilities of undergoing HSCT range from 0.23% to 0.98% under the various scenarios. We conclude that, given current indications, the lifetime probability of undergoing autologous or allogeneic HSCT is much higher than previously reported by others and could rise even higher with increases in donor availability and HSCT applicability.
July 2007
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23 Reads
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7 Citations
EMBO Reports
Citations (7)
... In addition to reducing the usefulness of these data, it has also been revealed in recent re-identification (de-anonymization) attack studies on such 'anonymized neuroimages', that the presumed anonymity provided by these techniques is compromised by both the uniqueness of the image and availability of advanced pattern recognition technologies (Ravindra and Grama, 2019;Schwarz et al., 2019). This means that datasets often referred to as 'anonymized' can mostly be reidentified (Knoppers et al., 2012;Loukides et al., 2010;Rocher et al., 2019;Rothstein, 2010). In their study, Rocher et al. (2019) concluded that it is possible to correctly re-identify 99.98% of Americans in any dataset using 15 demographic attributes and irrespective of applying anonymization techniques. ...
- Citing Article
September 2012
The American Journal of Human Genetics
... 57 In biobanks, patient cases and related information are stored anonymously and marked with a PIN code that is generated based on the individual biological characteristics to uniquely distinguish the sample depositors. 58,59 Cancer organoid culture platforms can capture the heterogeneity and pharmacotypic signatures of the parental tumours. Clinical trials have been performed using patient-derived organoids as a tool for personalized medical decisions to predict patients' responses to therapeutic regimens and potentially improve treatment outcomes. ...
- Citing Article
- Full-text available
March 2011
Nature Reviews Cancer
... [25][26][27][28] A recent statistical analysis has shown that private banking is not cost-effective. 29,30 If everyone donates cord blood to public registries, there is an increased chance of someone benefiting from a double cord blood transplant. ...
- Citing Article
May 2010
Obstetrics and Gynecology
... Some believe that the decision to preserve a child's cord blood is a personal choice that should not be based on statistical or medico-economic analyses. 76 This argument does not take account of the difficulties inherent in each individual properly assessing the risks they face. Behavioral studies on decision-making show that in the presence of extremely rare events, individuals tend to significantly overestimate their probability. ...
Reference:
Industrial Economics of Cord Blood Banks
- Citing Article
November 2008
Nature Reviews Cancer
... Because the effectiveness of scientific and Big Data analysis do not generally depend on the individual identities of their subjects, by anonymizing the data-that is, irreversibly disassociating the subjects' identities-the leading current of thought held that use and disclosure could be free of any significant risk of adverse privacy consequences. 2 Even in the context of rich, multidimensional data, advocates could once be found favouring the idea that genomic data is anonymized when no direct identifiers are included, such as a person's name or telephone number (Nietfeld 2007;Lowrance 2002, 34). ...
- Citing Article
July 2007
EMBO Reports
... As a result, the umbilical cord was no longer thought of as a wasted tissue after delivery but rather as an alternative and valuable source of stem cells (8,9). The American Association of Blood institutions (AABB) has only recognized 76 of the 720 stem cell institutions in the world; Cell Safe Bank is one of them (10) . The first stem cell bank in the Middle East and Egypt is called Cell Safe Bank. ...
- Citing Article
- Full-text available
April 2008
Biology of Blood and Marrow Transplantation
... A study by Neitfeld et al. aimed to determine the likelihood of a person requiring a BM transplant over his or her lifetime [ 15 ]. Under different treatment scenarios such as autologous versus allogeneic CB use, the lifetime probability of a person requiring a BMT was between 1/100 and 1/400, with the probability of use increasing with age. ...
- Citing Article
- Full-text available
July 2008
Biology of Blood and Marrow Transplantation