June 2024
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2 Reads
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June 2024
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2 Reads
November 2023
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10 Reads
European Heart Journal
Background Incomplete revascularization of non-infarct related arteries (IRA) leads to worse outcomes in patients with acute myocardial infarction (AMI) and multivessel coronary artery disease (MVD). Outcomes of fractional flow reserve (FFR)- and angiography-guided percutaneous coronary intervention (PCI) for non-IRA may differ according to their location between the anterior descending artery (LAD) and non-LAD. Aims We investigated the impact of FFR- versus angiography-guided PCI on clinical outcomes according to the location of non-IRA (LAD versus non-LAD) in AMI patients with MVD. Methods This trial was a pre-specified post-hoc analysis of the FRAME-AMI study, an investigator-initiated, randomized, open-label, multicenter trial at 14 sites in Korea. In the FRAME-AMI trial, PCI was performed for non-IRA in 64.1% (FFR £0.80) and 97.1% (diameter stenosis of >50%) in FFR-guided PCI and angiography-guided PCI groups, respectively. We grouped the patients into four according to treatment strategy (FFR versus angiography) and location of non-IRA (LAD vs. non-LAD). The primary endpoint was a composite of time to death, MI, or repeat revascularization. Results Patients with non-IRA involving LAD and non-LAD were 55.0% and 45.0%, respectively. The proportion of performed PCI (82.2% vs. 78.3%, p=0.242) and the rate of the primary outcome (9.4% vs. 11.5%, p=0.421) were similar between LAD and non-LAD. Among patients with non-IRA involving LAD, the FFR-guided group had a fewer events rate of the primary outcome than the angiography-guided group (5.7% vs. 14.3%, p=0.010). Among those with non-IRA not involving LAD, the FFR-guided group tended to the lower incidence of the primary outcome compared to the angiography-guided group (7.4% vs. 14.5%, p=0.081). However, the effect of the interaction between LAD and non-LAD on the primary outcome was not found (p for interaction 0.667). Conclusions In AMI patients with MVD, FFR-directed PCI for non-IRA was superior to angiography-guided PCI regardless of the location of non-IRA. The benefit of an FFR-directed revascularization strategy for non-IRA is likely enhanced in LAD.
November 2023
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5 Reads
European Heart Journal
Background Discrepancies between quantitative coronary angiography (QCA) and fractional flow reserve (FFR) or intravascular ultrasound (IVUS) are often observed in coronary lesions with intermediate stenosis. Objectives We investigated the impact of physiology- or intracoronary imaging-directed revascularization strategies on clinical outcomes in patients with discordant coronary lesions between QCA and FFR or IVUS. Methods This study was a post hoc analysis of the FLAVOUR study, an investigator-initiated, prospective, randomized, open-label, multinational trial performed at 18 sites in Korea and China. In the FLAVOUR study, 200 patients with ≥60% diameter stenosis (DS) deferred percutaneous coronary intervention (PCI) according to FFR > 0.8 (n=141) or a minimal lumen area > 3 mm2 or 3-4 mm2 with a plaque burden <70% on IVUS whereas 351 patients with <60% DS performed PCI according to positive FFR (n=118) or positive IVUS (n=233) results. The primary outcome was a patient-oriented composite outcome (POCO), a composite of death, myocardial infarction, or revascularization. Results The incidence of discordance was 28.1% in the FFR group and 32.4% in the IVUS group. At 24 months, among patients with ≥60% DS, the incidence of POCO was similar between FFR-guided and IVUS-guided deferral strategies (4.4% vs. 3.4%, p=0.757). Among patients with <60% DS, FFR-directed or IVUS-directed PCI did not differ in the POCO incidence (5.2% vs. 2.6%, p=0.207). However, FFR-guided PCI showed a higher incidence of periprocedural myocardial infarction than IVUS-guided PCI in <60% DS lesions (2.6% vs. 0.0%, p=0.014). Conclusions In patients with discordant intermediate stenosis between QCA and FFR or IVUS, physiology- and imaging-directed revascularization strategies are comparable concerning POCO at 24 months.
June 2023
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24 Reads
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9 Citations
June 2023
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714 Reads
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34 Citations
June 2023
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26 Reads
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1 Citation
March 2023
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16 Reads
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1 Citation
December 2022
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15 Reads
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5 Citations
December 2022
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63 Reads
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36 Citations
June 2022
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26 Reads
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4 Citations
... LEL can present as unilateral or bilateral following surgical treatment. Most often LEL presents unilaterally; however, approximately 20% of LEL is bilateral [13,43,44,94,99]. Our difference in leg circumference measures may have missed bilateral LEL and partially account for the higher prevalence identified by the GCLQ. ...
December 2020
... Such stray magnetic fields could originate from the RL and synthetic antiferromagnet (SAF) layers in the MTJ structure [10]. Other modes for increased WER could be back-hopping [11], process variations, inhomogeneity of material parameters [12], etc. Our recent study employing micromagnetic simulations showed that poorly designed SAF and RL layers could cause WER ballooning in MTJ devices with relatively larger diameters [10]. ...
June 2023
... An alternative design involves a fully vertical arrangement 131 , where the capacitor is aligned with the channel to enhance device performance. Both of these 3D integration methods share a similar framework and operational principles to those used in VC-FeNAND technology, which has been shown to deliver high-density storage solutions.The vertical stacking 3D 1T-1C FeRAM architecture utilizes monolithic stacking to achieve high memory density and performance, similar to the 3D DRAM132,133 . For each layer, a horizontal gate-all-around (GAA) access transistor and horizontal MFM or metalferroelectric-semiconductor (MFS) capacitor can be adopted. ...
June 2023
... In the miniaturization process, the channel size is cut down, which decreases the distance between the source and drain and effectively reduces the performance of the device by encountering the SCEs. To avoid these issues, spacers are introduced between the two potential terminals of the device, which allow downscaling of the device to a sub-10 nm regime [5,6,[20][21][22][23]. Sreenivasulu et al [6], further enhanced the device performance by combining the High-K spacer to minimize the series resistance of the substrate and enhance the drain current. ...
June 2016
... At IEDM 2022, the 28 nm MRAM was also presented as a standalone technology with operating voltages of 1.8/3.3 V, operating temperatures of −40 to 85℃, 40/160 ns read/write speed, a switching endurance of 10 14 cycles, although at −25℃, and 10 years data retention at 89℃. [60] In the same paper, a further improvement to an embedded 14 nm node was presented (−40 to 105℃ operating temperature, 15/50 ns read/write speed, 12 pJ/bit write energy), and the 14 nm automotive technology was presented at VLSI 2024 with a switching endurance of 10 12 cycles, 100 ns write speed, and 10 years data retention at 150℃. [61] Also at VLSI 2024, in collaboration with IBM, <5 ns switching STT-MRAM was presented with high H c > 8 KOe and high E b > 80 k B T. [27] Samsung 8 nm MRAM is planned by 2026 and 5 nm by 2027. ...
December 2022
... Bit error rate of array. (a) Pre-optimization; (b) Pro-optimization.[88]. ...
Reference:
自旋轨道力矩磁性随机存储器制造工艺研究
December 2022
... These remarkable performances have been achieved through downscaling of device feature size, an optimized fabrication process, and optimized InGaAs channel materials for excellent transport properties. In addition, InGaAs channel MOSFETs have shown outstanding logic performance on various substrates, such as InP and flexible substrates, with extensive efforts to enhance their capability in new device structures, S/D Ohmic contacts, and optimization of the gate stack [4][5][6][7]. Meanwhile, large-size and cheaper-cost substrates will be essential for largevolume manufacturing from a mass production point of view, but an InP substrate is more expensive than a GaAs substrate, and the size to date is limited to 6 inches. ...
June 2022
... Samsung demonstrated a denser 28 nm node eMRAM (13.9 Mb mm -2 ) for use as a frame-buffer memory in CMOS image sensor applications, a very different application to eNVM, with 10 10 write endurance over the operating range −20 °C to 85 °C, and a fast write of 50 ns relative to 200 ns for eNVM for standard eFlash replacement. The trade-off is that only 1 s retention at 85 °C is needed for this application 30 . Sony has also demonstrated a 40 nm node eMRAM for use as a buffer memory for CMOS image sensor applications 31 . ...
December 2021
... is at the heart of MRAM technology [3,4], and has proven particularly effective in tunnel magnetoresistive devices and circuits [5,6]. Spin transfer torque (STT)-MRAM devices with a CoFeB/MgO/CoFeB heterostructure provide high thermal stability and a low damping constant [7]. ...
March 2021
... In-memory computing (IMC) and near-memory computing (NMC) with an embedded memory are promising solutions to address these issues [1], [2], [3]. Recently, several candidates have been proposed for embedded memory applications such as eDRAM [4], RRAM [5], and MRAM [6]. Although memory elements are placed in a back-end-of-line (BEOL) layer in a conventional embedded memory architecture, access transistors are located in a front-end-of-line (FEOL) layer. ...
December 2020