J.C. Szepietowski's research while affiliated with Wroclaw Medical University and other places

Publications (252)

Article
Background Study TR03 evaluated the safety and efficacy of nalbuphine ER for prurigo nodularis (PN) (NCT02174419). Objective We conducted supplementary analyses to assess the psychometric properties of the Worst Itch Numeric Rating Scale (WI-NRS), the TR03 primary endpoint. Methods Study TR03 was a double-blind, placebo-controlled, phase 2 trial...
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Background Treatment of prurigo nodularis (PN) is challenging and new treatment options are needed. Objective To evaluate the efficacy and safety of two oral doses of the kappa opioid agonist and mu opioid antagonist nalbuphine extended release (NAL-ER) tablets in a phase 2, multicentre, randomized, double-blind, placebo-controlled trial with an o...
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Core outcome sets (COSs) are an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. Tsekhe aim of our position paper by the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life and Patient Oriented Outcomes was to identify the chall...
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Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged...
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A 74-year-old Caucasian male presented to Dermatology Department with multiple hemorrhagic blisters on oral and nasal mucosa and purpuric rash on lower extremities. The cutaneous lesions appeared for the first time a day before admission, firstly on patient’s thighs and then spread to lower legs and forearms. Moreover, that morning patient woke up...
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A 46‐year‐old Caucasian male presented with psoriasis flare up, which occurred a day after second dose of COVID‐19 Pfizer‐BioNTech BNT16B2b2 mRNA vaccine. The patient had been suffering from plaque psoriasis for 24 years. During the last 21 months his psoriasis was completely clear (PASI 0 points) due to deucravacitinib treatment in the clinical tr...
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New treatment options may lead to an increased interest in using reliable and sensitive instruments to assess health‐related quality of life in people with alopecia areata (AA). The purpose of this paper is to present current knowledge about quality of life assessment in AA. The dermatology‐specific Dermatology Life Quality Index (DLQI) was the mos...
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Background Ruxolitinib (RUX) cream demonstrated potent anti-inflammatory and antipruritic efficacy in a phase 2 study in adults with atopic dermatitis (AD). Objective To evaluate 8-week efficacy and safety in two phase 3 studies of RUX cream in patients with AD Methods TRuE-AD1 (NCT03745638) and TRuE-AD2 (NCT03745651) enrolled patients aged ≥12 y...
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Background Dermatophytosis is a world‐wide distributed common infection. Antifungal drug resistance in dermatophytosis used to be rare, but unfortunately the current Indian epidemic of atypical widespread recalcitrant and terbinafine‐resistant dermatophytosis is spreading and has sporadically been reported in Europe. Objectives To explore the occu...
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Background Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current Hidradenitis Suppurativa (HS) guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. Objective To assess the 12-week efficacy of oral tetracyclines and a combination...
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Background Chronic pruritus (CP) is a subjective symptom and it is necessary to assess its intensity with validated patient‐reported outcome tools in order to allow determination of the treatment course. Objectives So far, the itch intensity scales were validated in small cohorts and in single languages. Here, we report the validation of the numer...
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Chronic nodular prurigo is characterized by recalcitrant itch. Patient perspectives on therapeutic goals, satisfaction with therapy and efficacy of therapeutic regimens for this condition are unknown. This questionnaire study examined these issues in 406 patients with chronic nodular prurigo from 15 European dermatological centres. Improvements in...
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Background Itch is a common symptom in the general population. Affected individuals often do not seek medical consultation and rely on internet searches to obtain information regarding their itch. Objectives The aim of this study was to attain insights into common concerns of the general population regarding itch can by analyzing itch‐related inte...
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Gel nail polish is commonly used in manicures; how-ever, research into the side-effects of gel nail polish is scarce and focusses mainly on allergic contact dermatitis. The aim of this study was to assess the frequency and characteristics of side-effects associated with use of gel nail polish. A self-questionnaire survey was conducted on a represen...
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Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action. Objectives: The objective of the study was to investigate ser...
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Background The impact of Malassezia yeasts on skin mycobiome and health has received considerable attention recently. Pityriasis versicolor (PV), a common dermatosis caused by Malassezia genus worldwide, is a manifestation of dysbiosis. PV can be associated with hyper- and/or hypopigmented skin lesions. This disease entity is characterized by high...
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Background: As treatment interruptions occur during psoriasis management in clinical practice, it is important to know the duration of clinical response after treatment withdrawal. Objectives: To report time to and predictors of relapse in patients who were tildrakizumab 100 and 200 mg responders (≥75% improvement in Psoriasis Area and Severity...
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Background: Psoriasis is a chronic skin condition that in one third of cases starts in the first two decades of life. The disease might impact the quality of life (QoL) of the affected children and their caregivers. The issue of gender differences in the assessment of psychological burden of dermatological conditions has been the subject of few st...
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Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult non-obese patients suffering fr...
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Recombinant interferon beta‐1b is one of the treatment options of multiple sclerosis (MS). Insertional biologics that are used in the treatment of MS may lead to skin adverse effects, for example, morphea.
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Axitinib is a tyrosine kinase inhibitor of vascular endothelial growth factor (VEGF) receptor affecting tumour cell angiogenesis and proliferation. It is approved for the treatment of solid tumours, including renal cell carcinoma and hepatocellular carcinoma1. In January 2020 a 48‐year‐old white male with metastatic renal cell carcinoma was admitte...
Article
The European Academy of Dermatology and Venereology (EADV) has started the ‘Healthy Skin @ Work’ campaign aimed to raise awareness among the public and EU authorities on the frequency and impact of occupational skin diseases (OSDs). The EADV Task Forces (TFs) on Quality of Life and Patient Oriented Outcomes (QoL/PO) and on OSD present their mutual...
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The pandemic of COVID‐19 is a global challenge for health care and dermatologists are not standing apart from trying to meet this challenge. The European Academy of Dermatology and Venereology (EADV) has collected recommendations from its Task Forces (TFs) related to COVID‐19. The Journal of the EADV has established a COVID‐19 Special Forum giving...
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Basal cell carcinomas (BCC) are the most common types of skin neoplasm. The finger, toe, and nail unit are uncommon and rare locations of BCC. Only a few patients with foot BCC have been reported, and ungual BCC is even less frequent. We present a patient with a BCC on the left first toe. Clinically, it appeared as a brown‐colored plaque with an ir...
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Background: Uremic pruritus is a common symptom in patients with chronic kidney disease undergoing hemodialysis (HD) treatment. Etiopathogenesis of uremic pruritus is complex and not fully explained, but there are reports indicating a possible role of peripheral opioid system in its pathomechanism. Objectives: This study was undertaken to analyz...
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Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease with the involvement of intertriginous areas. Recently, a crucial role of aberrant innate immune response and keratinocyte activation in the pathogenesis of HS has been suggested 1‐6. S100 proteins have emerged as an important player of innate immunity.
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Background: Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behavior and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking. Objectives: Aim of this pan-European m...
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Background: Hidradenitis suppurativa is a debilitating disease related to a great psychosocial burden in affected patients and subsequently also people around them. Patients' partners as caregivers may indirectly experience wide range of devastating effects of the disease on their emotional and social life. Objective: The purpose of this study w...
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Atopic dermatitis (AD) is a chronic skin disease with the etiology not yet conclusively established. Recent reports demonstrate the role of serotonin (5-hydroxytryptamine; 5-HT) in the pathogenesis of AD. The aim of this study was to investigate the relationship between the serum content of serotonin and depression in adult patients suffering from...
Chapter
Pityriasis rubra pilaris (PRP) is an idiopathic, papulosquamous disease with two age peaks in the first and fifth decade of life
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Introduction: Many atopic dermatitis (AD) patients suffer from insomnia. Out of numerous factors associated with sleep disorders, melatonin seems to play a significant role. Aim: To assess the relation between melatonin concentration and sleep disorders in adult patients with severe and very severe AD. Material and methods: The study included...
Article
Introduction Le dupilumab (DPL) est approuvé dans plusieurs pays pour le traitement des patients (pts) adultes souffrant de dermatite atopique (DA) modérée à sévère insuffisamment contrôlée. Matériel et méthodes Il s’agit d’une analyse post-hoc des données groupées de deux essais de phase 3 (SOLO1 : NCT02277743 ; SOLO2 : NCT02277769) visant à déte...
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Introduction Le dupilumab (DPL), anticorps monoclonal entièrement humain, bloque le récepteur commun aux interleukines IL-4 et IL-13 ; il est approuvé aux États-Unis pour les patients âgés de 12 ans et plus atteints de dermatite atopique (DA) modérée à sévère insuffisamment contrôlée par des traitements topiques ou chez qui ces traitements sont déc...
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The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper fo...
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Background: Psoriasis is a chronic inflammatory skin disease associated with quality of life (QoL) impairment. BRIDGE was a randomised, double-blind, phase III study comparing the efficacy and safety of dimethylfumarate (DMF) with a fixed combination of fumaric acid esters (FAE) or placebo for the treatment of moderate-to-severe psoriasis. Object...
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Background: Itch is an integral part of clinical picture of superficial dermatophytoses which constitute a common and growing problem in India. Objectives: The study aimed to evaluate the prevalence, intensity and clinical characteristics of itch in superficial dermatophytosis. Methods: The data concerning disease history and clinical type of...
Chapter
Allergic contact dermatitis is caused by type IV delayed hypersensitivity reaction
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A. Wollenberg S. Barbarot T. Bieber S. Christen-Zaech M. Deleuran A. Fink-Wagner U. Gieler G. Girolomoni S. Lau A. Muraro M. Czarnecka-Operacz T. Schäfer P. Schmid-Grendelmeier D. Simon Z. Szalai J.C. Szepietowski A. Taïeb A. Torrelo T. Werfel J. Ring For the European Dermatology Forum (EDF), the European Academy of Dermatology and Venereology (EAD...
Article
银屑病是一种慢性皮肤炎症性疾病。这种疾病最常见的形式是斑块状银屑病,患者身上可能大面积出现突起、发红且通常呈鳞片状的炎症区域。虽然一般不会致命,但银屑病可能会使其他严重疾病的风险增加(如心血管疾病),而且通常导致患者的生活质量大幅降低,造成身体不适(瘙痒、疼痛)、残疾及相关情感创伤。此外,银屑病在世界各地都有出现(许多国家的患者群体高达3%),而且无法通过现有治疗完全治愈。上述问题使这种疾病成为严重的全球负担。粒细胞‐巨噬细胞集落‐刺激因子 (GM‐CSF) 在体内生成,而且对控制身体免疫系统机能及炎症相关过程很重要。因此,本次研究旨在明确阻断中度或重度斑块状银屑病患者体内GM‐CSF的活性是否会使疾病显著改善。从加拿大、丹麦、德国、拉脱维亚和波兰招募了共计122名患者。这些患者在10周内接...
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Psoriasis is a long‐lasting disease involving inflammation of the skin. In the most common form of this disease ‐ plaque psoriasis ‐ the inflammation is visible as raised, reddened and often scaly areas which may extend widely over the body. Although not generally a life‐threatening condition, psoriasis may increase the risk of other serious disord...
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Methotrexate is a systemic immunosuppressant drug that is used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis and hypertension. This study aimed at exploring the possible hyperglycaemic effects of methotrexate in psoriati...
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Background Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralises interleukin‐17A. Objective To assess the efficacy and safety of different maintenance‐dosing regimens of secukinumab 300 mg based on PASI response at Week 24 in patients with moderate to severe plaque psoriasis. Methods OPTIMISE was a randomised,...
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Among its wide spectrum of activities the European Academy of Dermatology and Venereology (EADV) organizes educational schools for specialists and residents on different subjects of dermatology and venereology. After Brussels (2014 and 2015), Dessau (2016) and Roskilde (2017), the EADV School on Hidradenitis suppurativa/acne inversa (HS) took this...
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Core outcome domains represent a major need in hidradenitis suppurativa/acne inversa (HS) as reliable disease classification systems and treatment outcome parameters. Thorlacius et al.¹ reported recently that none of the HS classifications systems could be recommended when used with HS experts as raters without a preceding bedside training session....
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The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non‐Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health‐related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify pub...
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Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis pa...
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This paper is organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Quality of Life (QoL) and Patient‐Oriented Outcomes and the EADV TF on acne, rosacea and hidradenitis suppurativa (ARHS). The purpose of this paper was to present current knowledge about QoL assessment in HS, including data on HS‐specifi...
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Background Hidradenitis suppurativa (HS), also referred to as acne inversa, is a debilitating skin disease characterized by inflammatory nodules, chronic abscesses and tunnels (fistulae and sinuses). The association with pilonidal sinus disease is frequently reported but not well documented. Objective To determine the prevalence and characteristic...
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Background The first dermatology‐specific proxy health related quality of life (HRQoL) instrument for children 0‐4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross‐cultural inequivalence focus groups work and pilot tests were organized si...
Article
Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Patients aged 65 years...
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Background: Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions and premature mortality. Objective: The study was aimed at investigating whether psoriatic patients, who carry risk allele of obesity-related FTO gene, are more predisposed to obesity and metabolic...
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According to the Global‐Burden‐of‐diseases study, chronic pruritus (CP) can be considered as one of the fifty central and most stressful diseases worldwide. (1) CP causes an unpleasant need to scratch and dramatically impacts patients’ quality of life. (2,3) Its origin can be dermatologic and non‐dermatologic. (4,5) Despite the fact that CP is affe...
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Background Chronic prurigo (CPG) is a distinct disease characterized by chronic pruritus, history and/or signs of prolonged scratching and multiple pruriginous lesions. It may present with various clinical manifestations, including papules, nodules, plaques or umbilicated lesions. Some patients with chronic pruritus show pruriginous linear and scar...
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Introduction: Psoriasis is an inflammatory disease of a complex pathogenesis and arthritis is one of its most common complications. The biological role of chitinase-3-like protein 1 remains unknown. It is suggested that this protein takes part in processes such as proliferation, inflammation and tissue remodelling. Aim: To determine whether YKL-...
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Background Chronic pruritus (CP) is a frequently occurring symptom in inflammatory dermatoses, causing a high burden and limitations to health related quality of life (HRQoL). Objective The ItchyQoL was developed to assess the impairment to HRQoL in patients with CP. However, it has only been validated in English and German. Here we report the val...
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Background The relevance of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in the management of psoriasis has not been studied previously. GM‐CSF is important in the initiation and maintenance of chronic inflammatory processes. Objective To investigate the clinical use of GM‐CSF neutralisation by evaluating the efficacy and safety of na...