J de Portugal Alvarez's research while affiliated with Hospital General Universitario Gregorio Marañón and other places

Publications (89)

Article
Neoplasms of unknown primary site are tumor diseases, which are diagnosed by the pathologic studies of one of their metastases. The treatment of neoplasms of unknown primary site is not totally established, except in a few situations with specific therapeutical implications, and a better prognosis. The usual treatment of neoplasms of unknown primar...
Article
Neoplasms of unknown primary site are tumor disseases, which are diagnosed by the pathologic studies of one of their metastases. The treatment of neoplasms of unknown primary site is not totally established, except in a few situations with specific therapeutical implications, and a better prognosis. The usuall treatment of neoplasms of unknown prim...
Article
We present the case of a patient with precedents of endometrial carcinoma treated by surgery and radiotherapy, which presented a psoas abscess by Streptococcus agalactiae as cause of fever of unknown origin, which answered favorably to the antibiotherapy and surgical drainage.
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Full-text available
The panniculitides or hypodermitis are a wide and heterogeneous group of diseases characterized by the presence of subcutaneous inflammatory nodules located generally in low limbs. Show the clinicopathologic characteristics of the cases diagnosed as panniculitis for a 5 years period; their epidemiology, etiopathogenic factors, evolution and treatme...
Article
Introduction: The panniculitides or hypodermitisare a wide and heterogeneous group of diseases characterized by the presence of subcutaneous inflammatory nodules located generally in low limbs. Objetives: Show the clinicopathologic characteristics ofthe cases diagnosed as panniculitis for a 5 years period; their epidemiology, etiopathogenic factors...
Article
The Internal Medicine Services have a central role in the medical care in our hospital system both as to the volume of patients attended and their variety, reflecting of the preparation and multi-tasking ability of their professionals. The current norms for coverage of heads-of-service demands the presentation of a management project that must test...
Article
The Internal Medicine Services have a central role in the medical attention of our hospital system so much as patients' volume attended like as their variety, reflex of the preparation and polyvalency of their professionals. The current regulation on coverage of service headquarters demands the presentation of a management project that must test ou...
Article
Kaposi's angiosarcoma (SK) is a vascular tumour that affects skin and other organs. Nowadays there is thought that immunosuppression is one of the factors related with its genesis. Show the information corresponding to the distribution of the SK, proportion of subtypes, evolution and therapeutic used. A 28 cases retrospective study. We obtained the...
Article
El angiosarcoma de Kaposi (SK) es un tumor vascular que afecta a piel y otros organos. Actualmente se piensa que en su genesis intervienen factores relacionados con la inmunosupresion. Objetivos: Reflejar los datos correspondientes a la distribucion del SK, proporcion de subtipos, evolucion y terapeutica empleada. Material y metodos: Estudio re...
Article
The epidemiologic importance of iron overload disorders and the clinical lack of its diagnosis led us to an active search of cases among the hospitalized patients in a general university hospital. This situation will make it possible to have a larger and earlier number of diagnosis together with a preventive intervention and an effective treatment....
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Full-text available
We present a case of a man 84 years-old, whose presentation feature was a cutaneous inespecific rash, and was diagnosed of T prolymphocytic leukaemia (T-PLL). In this review we analyze actual aspects concerning biology, diagnosis, classification, prognosis and treatment of this rare mature T cell leukaemia.
Article
Full-text available
We present a case of a man 84 years-old, whose presentation feature was a cutaneous inespecific rash, and was diagnosed of T prolymphocytic leukaemia (T-PLL). In this review we analize actual aspects concerning biology, diagnosis, classification, prognosis and treatment of this rare mature T cell leukaemia.
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Full-text available
We present a case of a man 84 years-old, whose presentation feature was a cutaneous inespecific rash, and was diagnosed of T prolymphocy- tic leukaemia (T-PLL). In this review we analize actual aspects concer - ning biology, diagnosis, classification, prognosis and treatment of this rare mature T cell leukaemia.
Article
Full-text available
La leucemia linfática prolinfocítica de células T (LPL-T) es una neoplasia hematológica infrecuente, de identificación relativamente reciente. Se caracteriza por presentar un curso clínico agresivo con linfocitosis elevada y afectación hepato-esplénica, ganglionar y cutánea, siendo precisamente una erupción cutánea el primer síntoma de nuestro caso...
Article
To ascertain the incidence of osteoporosis and epidemiological factors in patients admitted to an Internal Medicine Service of a University General Hospital in Madrid, Spain. We also took into account the reasons for admission, associated diseases, and the preventive and therapeutic diagnostic implications. The analytical, descriptive, retrospectiv...
Article
Objetivo: Conocer la incidencia de osteoporosis en los pacientes ingresados en un servicio de medicina interna de un hospital de tercer nivel, motivos de ingreso, patologías asociadas e implicaciones diagnósticas, preventivas y terapéuticas. Pacientes y métodos: Estudio transversal, retrospectivo, descriptivo y analítico de 100 pacientes mayores de...
Article
In order to increase our knowledge of adult haemochromatosis epidemiology and its clinical behaviour in young patients, we studied 4 patients from 3 pedigrees with idiopathic haemochromatosis. Diagnostic criteria were: 1) Discarding the presence of secondary haemosiderosis. 2) Histological and histochemical confirmation of hepatic iron overload. Me...
Article
To know if the determination of the angiotensin converting enzyme in serum (SACE) and lung (LACE) may be useful as a marker of acute lung injury (ALI) in the adult respiratory distress syndrome (ARDS). By reproducing in a experimental model of ALI with oleic acid in dogs which simulate the early stage of ARDS, we have correlated the pathologic and...
Article
Enterococcal endocarditis accounts for 10% of all bacterial endocardits. The infection progresses in a subacute way and when localized on the aortic valve it has a very poor prognosis since the valve is usually destroyed being death the fatal outcome. We report a case of a patient with infective endocarditis resulting from the implantion of the Ent...
Article
Out of 200 patients diagnosed of acute of chronic brucellosis, cases were first selected who had neurologic involvement (14%) and then those who had brucellar meningitis (CDC criteria) which corresponds to 4% of the total of the series. The clinical course, evolution time, neurologic manifestations and serologic and bacteriologic characteristics in...
Article
The patient, a 78-year-old female with history of headache and progressive gait disturbance for almost one year, was admitted to our department because of dysphagia and dysphonia since three months before. Neurological examination revealed nystagmus, cerebellar ataxia, deafness, and vesical incontinence. No cerebral injuries were detected by comput...
Article
We report a 20-year-old man affected by glycogenosis type III with distal muscle weakness, more severe in distal leg muscles. The electromyogram showed myopathic features. Nerve conduction studies and central motor conduction after magnetic stimulation of the brain were normal. Our results suggest that there is no involvement of central motor pathw...
Article
A clinical and therapeutical study of 47 patients with the diagnosis of acute pancreatitis is reported. According to Ranson's criteria patients were initially classified as suffering from mild (28) and severe (18) acute pancreatitis. Twenty-eight, 11, 7 and 1 patients had biliary, alcoholic, idiopathic and neoplastic causes, respectively, of their...
Article
Three groups of men and three groups of women were studied, each one of the three corresponding to obese individuals, overweight and not overweight according to the ratio of corporal mass > or = 30, 25-29.9 and < 25 respectively. In each group two subgroups were made following the waist/hip ratio (< 1 and > or = 1 for men and < 0.8 and > or = 0.8 f...
Article
Isolated general malaise (IGM) is defined as an imprecise sensation of feeling bad, without any other signs or symptoms that suggest even a diagnostic orientation. 137 patients who demanded medical help for IGM were selected and divided into three groups, according to their evolution: IGM of banal or benign cause; IGM of easy or attainable diagnosi...
Article
The potential associations between the factors making up the vascular multi-risk metabolic syndrome (VMMS) or syndrome X (hypertension, diabetes, lipidic disorders, hyperinsulinemia and obesity) are studied: a) in patients with recent cerebral infarct or acute myocardial infarct; b) in patients hospitalized for the management of their hypertension,...
Article
Some authors do not accept as valid the clinical diagnosis of gastritis, due to the latter being mainly an anatomical-pathological term. Others, however, argue that such diagnosis may be establish through a correct anamnesis. A cross-sectional study of a hundred and fifty patients undergoing fibrosgastroscopy with antral biopsy and anamnesis, as we...
Article
We have conducted a blind cross-selectional study with 150 consecutive patients undergoing fibrogastroscopy and biopsy of the antral mucosa. The endoscopic sensitivity for the diagnosis of the several types of gastritis, is low (63%), although this technique is highly sensitive for other types of pathology. Consequently, we conclude that, in all en...
Article
Fibronectin (Fn) is a glycoprotein secreted principally by vascular endothelial cells and its main function is to maintain the adhesion between the various cells and the substrates. Owing to these two features, the glycoprotein participates in several pathologies affecting blood vessels, such as atherosclerosis and diabetes mellitus (DM). In this p...
Article
Fibronectin is a high molecular weight glycoprotein which forms part of the basal membrane and is found in plasma that has suffered quantitative alterations during the development of various pathological processes. The aim of this paper is to study, in diabetic patients, the quantitative seric changes of this protein in relation to diabetes mellitu...
Article
Liver abscesses are not very frequent and those produced by Klebsiella spp. are quite exceptional. These germs have been related to the development of acute anterior uveitis (AAU) in patients whose susceptibility has been linked to HLA B27. We present a case of a female, HLA B27 negative, who developed AAU during a course of liver abscesses caused...
Article
The value of seric activity of adenosine deaminase has been detected in four group of patients with liver disease: acute viral hepatitis in 32 cases, liver cirrhosis in 30 cases, liver neoplasia in 12 cases, and cholelithiasis in 20 cases, against 30 patients as a control group. In addition, we studied 3 patients with alcoholic hepatitis and 1 with...
Article
The seric activity of the enzyme NAG (N-acetyl-beta-D-glucosaminidase) was studied in 3 groups of patients with jaundice of different etiology (extrahepatic, intrahepatic and acute hepatitis) and in a control group, in order to observe the discrimination capacity of this enzyme in each group. After the use of a fluorimetric method, the results were...
Article
Two cases of pneumonia in which the initial radiologic sign was the solitary nodule are presented. The symptoms associated permitted the infectious origin. The clinical and radiological evolution after antibiotic therapy supported the diagnosis of rounded pneumonia. We highlight the need to discard benign lesions causing the solitary nodule, before...
Article
The finding of immunoreactive insulin (IRI) in saliva and an insulin-like protein, similar to pancreatic insulin and with the same biological activities, suggest that both products are pancreatic insulin stored and/or eliminated in the salival manner or an extrapancreatic hormone synthesis, bearing in mind the features which both glands share. The...
Article
Full-text available
The nerve action potential at the elbow and somatosensory evoked potentials (SEPs) at the scalp were recorded over 30 minutes of tourniquet-induced limb ischaemia in 10 diabetic patients and 10 controls. According to the SEP changes, an increased resistance to nerve ischaemia in diabetic patients was observed. The pathways involved in SEP conductio...

Citations

... Por otro lado, las plantas de hospitalización convencional, especialmente los servicios de medicina interna, atienden un porcentaje muy importante de pacientes hospitalizados, muchos de ellos en el período final de su vida 9 . Sin embargo, apenas existe información consistente sobre las medidas de adecuación o limitación de ingreso que se aplican a estos pacientes, cuyas características demográficas y clínicas difieren considerablemente de las de los pacientes ingresados en otros servicios 10 . ...
... En la variedad de carcinoma escamoso, la totalidad de las metástasis asentaron en ganglios y en el grupo de carcinoma neuroendocrino al nivel de hígado, pulmón y pleura. Estos resultados coinciden con los reportados en la literatura en el caso de las variedades de adenocarcinoma bien diferenciado, poco diferenciado y carcinoma escamoso 40,42 y no así en el caso de los tumores neuroendocrinos donde, según estudio realizado por Hainsworth y otros, 43 los sitios de metástasis más frecuentes identificados son las estructuras retroperitoneales (20 %), ganglios periféricos (14 %), mediastino (12 %), hígado (12 %) y huesos (11 %). Estas diferencias pudiesen ser dependientes del número de casos (10) con variedad neuroendocrina presentes en nuestra serie. ...
... In our setting, the most frequently diagnosed form of panniculitis is erythema nodosum, followed by sclerosing panniculitis and nodular vasculitis/ erythema induratum of Bazin. 7 The objective of this study was to assess the capability of dermatologic US for subtyping predominantly septal/lobular panniculitis, using a histopathologic study from a cutaneous biopsy as the reference standard, and a blind dermatologic US evaluation of images without clinical information for assessing intra-and inter-rater agreement. ...
... La HAMP a la cual se le reconoce actividad es un péptido catiónico con 25 aminoácidos y 4 puentes disulfuro que unen los 8 residuos de cisteína (44), confiriéndole una carga total positiva y una tendencia a presentar estructuras secundarias anfipáticas, propiedad que permite a los péptidos antimicrobianos penetrar membranas de los microorganismos invasores (5). ...
... El sarcoma de Kaposi (SK), llamado también angiosarcoma de Kaposi o sarcoma hemorrágico idiopático múltiple, es un tumor de estirpe endotelial localmente agresivo, predominantemente de varones, entre 30 y 90 años, judíos y de ascendencia mediterránea 1 los vasculares múltiples en la piel y los órganos viscerales 3,4 . Se reconocen cuatro formas diferentes clínico-epidemiológicas: a) la clásica indolente; b) la endémica africana; c) la iatrogénica, y d) la asociada al VIH/sida. ...
... La hepcidina participa en la patogénesis de la hemocromatosis tipo 1 y se ha descrito que el défi cit del gen HEF determina una producción insufi ciente de este péptido y puede modular además, la expresión de otros genes y mutaciones en el resto de las enfermedades con sobrecarga de hierro no asociadas al gen HEF (12,35), por lo que se concluye que ambos genes y este péptido pudieran estar relacionados (25). ...
... To date, S100B is the only TBI salivary marker expected to have excellent negative predictive value. We used the following references to obtain these values: for insulin [41,42], EGF [43], HGH [44], S100B [40,[45][46][47], PSA [48]. There are no reports, to our knowledge, of saliva content of BDNF, GFAP, NF-L. ...
... The quantification of ADA activity has been previously performed in sheep lymphoid cells during antibody production after antigenic stimulation (10), peripheral blood cells of patients with hematological disorders, such as lymphoid leukemia and myeloma (11), serum from patients with different liver disorders (12), serum from patients with acquired immunodeficiency virus (HIV) infection (13), synovial fluid from patients with rheumatoid arthritis (14), serum from patients with tuberculous meningitis (15), serum from patients with chronic lymphoid leukemia (16), and other sources. ADA activity has also been characterized in leukemic cells (17), normal epidermal and carcinoma cells (18), mouse intestines (19), human and chicken livers (20), mollusk (Biomphalaria glabrata) hemolymph (21), and zebrafish brain (22). ...
... However recent studies report more frequent mediastinal localization of TB in the adult [23]. In our department an increase of extrapulmonary TB is observed, lymph node localization being the second in frequency [24]. Complications resulting from mediastinal TB such as fistulae and compression of adjacent structures have been described in children [25] and in adults [26,27). ...
... However whenever measuring skin fold is not feasible WC and WHR can be reliable indicator of HTN based on our results. Our result also confirms with some of other studies that have found that WHR have been found to be[34][35][36][37][38][39][40] a more efficient predictor of HTN than the BMI . The result also indorses the statement from one of research article that if obesity is redefined using WHR instead of BMI, the proportion of people categorized as at risk of heart attack worldwide 41 increases threefold . ...