J Z Yang’s scientific contributions

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Publications (1)

FIG. 2. Percentage of endometrial implants surviving vs. time in monkeys with surgical induction of endometriosis. Five endometrial fragments of equal size (4 1 mm 2 ) were auto-transplanted to various sites in the pelvis of each monkey. Each animal was treated with TCDD at doses of 0, 0.71, 3.57, and 17.86 ng/kg/day over the course of one year; n 5 for controls, n 6 for the 3 dose groups (low, medium, and high, respectively). *Indicates significance vs. controls at the p 0.05 level. 
FIG. 3. Mean SEM of maximum and minimum endometrial implant diameters at necropsy in monkeys with surgical induction of endometriosis and treated with TCDD at doses of at 0, 0.71, 3.57, and 17.86 ng/kg/day over the course of one year; n 5 for controls, n 6 for the 3 dose groups (low, medium, and high, respectively). *Indicates significance vs. controls at the p 0.05 level. 
FIG. 4. Representative photomicrographs of endometrial implants from animals dosed with TCDD at 0, 0.71, 3.57, and 17.86 ng/kg/day. (A) Endometrial glands in a control animal were tortuous, as suggested by various sizes and shapes of these glands. Crowded columnar epithelial cells line the open lumen of the glands. Large quantities of inflammatory infiltrates were also found on the section. (B) Endometriotic cysts were observed in the low-dose group (0.71 ng/kg/day TCDD) with a suppressed epithelial lining. (C) Sections from the moderate-dose group (3.57 ng/kg/day TCDD) were characterized by highly tortuous endometrial glands. Nuclei were located at various positions within epithelial cells. (D) Cystic endometrial glands were observed in sections from animals of the high (17.86 ng/kg/day)-dose group. Epithelial cells lining the lumen of the glands were columnar, and nuclei were displaced from their basal location and found centrally and apically positioned in these cells. Magnification 300. 
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Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey
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September 2000

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Toxicological Sciences

J Z Yang

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An increase in the incidence and severity of endometriosis following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was a serendipitous finding in a reproductive toxicology study in rhesus monkeys. The purpose of this study was to investigate the effects of subchronic exposure to TCDD on the survival and growth of surgically implanted endometrial fragments. Endometrial fragments of equal size (4 x 1 mm(2)) were auto-transplanted to the pelvic cavity of nulliparous cynomolgus monkeys (Macaca fascicularis, n = 23), who were divided into 4 treatment groups and dosed 5 days a week with gelatin capsules containing 0, 1, 5, or 25 ng/kg body weight of TCDD mixed with glucose. Endometrial implant survival was monitored by laparoscopy at intervals of 1, 3, and 6 months. Animals were euthanized at 12 months of treatment in the early to mid luteal phase and the maximal and minimal endometrial implant diameter was measured. Both the maximal and minimal diameters were significantly reduced in the 0.71-ng/kg/day-TCDD dose group, compared to controls, whereas the survival rate was unaffected (20 vs. 16%, respectively). In contrast, exposure to 3.57 and 17.86 ng/kg/day TCDD for 1 year resulted in a significantly higher survival rate of implants (26.7% and 33.3% respectively vs. 16.0%) and significantly larger diameter implants in the 17.86-ng/kg/day dose group only, compared to the control group. Treatment had no effect on circulating gonadal steroid levels or menstrual cycle characteristics. It is concluded that TCDD facilitates the survival of endometrial implants and exerts a bimodal effect on endometrial implant growth.

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Citations (1)

... The uterus plays an essential role in mammalian reproduction, and it is highly susceptible to endocrine-disrupting chemicals (EDCs) (Spencer et al. 2012). Exposure to some persistent organic pollutants has been shown to be related to the pathogenesis of endometrial diseases (Eskenazi et al. 2002;Yang et al. 2000). Pathological changes were observed in uterus of neonatal rats exposed to tributyltin (TBT), including thickened luminal epithelium, decreased glands, endometrial inflammation, and fibrosis (Chen et al. 2020). ...

Reference:

Chronic exposure to low levels of phenanthrene induces histological damage and carcinogenic risk in the uterus of female mice
Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey

Toxicological Sciences

J Z Yang

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