J. Van Staden's research while affiliated with University of KwaZulu-Natal and other places

Publications (844)

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With the human population increase, food production will be required to double. However, there is a direct correlation between prevalent abiotic stresses and yield reduction in crops. Cowpea (Vigna unguiculata) makes a staple meal in most diets worldwide, but its growth remains susceptible to stress. Biostimulants; vermicompost leachate (VCL), seaw...
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Medicinal plants are natural reserves of various therapeutic biomolecules. Orchids occupy a significant position among these. Ansellia africana is one of the most important orchids used in various pharmacopeias worldwide, especially in Traditional African Pharmacopeia (TAP). South Africa, in particular, houses approximately 494 species of orchids w...
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Ethnopharmacological relevance Traditional pharmacopoeias are constantly evolving and adapting, hence the assimilation of alien plants and weeds into traditional systems of healing. Invasive plants are detrimental to the ecosystem, however they are also potential sources of secondary metabolites with useful biological activities. Aim of the review:...
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Among the most destructive pests affecting plant growth and yield worldwide are root-knot nematodes (Meloidogyne spp.). Currently, the shift from the use of chemical nematicides is trangressing globally towards choices such as organic nematicides extracted from plant substances. Plant secondary metabolites have been identified as compounds responsi...
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Increasing incidences of combined drought and heat stress poses a serious threat to production and productivity of crops in sub-Saharan Africa where 95% of crop production is rainfed. In this review we discuss the morphological and physiological effects of drought and heat stresses, with specific emphasis on their combined effects on sorghum, a har...
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Isoquinoline alkaloids of the Amaryllidaceae have proven to be of significant value in drug discovery and development. Crossyne guttata is frequently used in traditional medicine as an antiseptic and wound cleaner as well as to treat alcoholism. The aim of the study was to identify the variation in alkaloid content of the species in relation to pub...
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Infection by the novel coronavirus SARS-CoV-2 causing the coronavirus disease (COVID-19), is currently a global pandemic with nearly two million deaths to date. Though a number of vaccines have recently been approved against the virus, availability remains a big challenge, and also acceptance by most people has become a big debate. This review disc...
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Gomphrena celosioides Mart is used traditionally for the treatment of urinary tract infections (UTIs) and related diseases in Asia and Africa. The study evaluated the antibacterial and anti-biofilm potentials of G. celosioides against β-lactamase producing Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. The leaves, twigs, flower...
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Background: Urinary tract infections (UTIs) caused by opportunistic pathogens are among the leading health challenges globally. Most available treatment options are failing as a result of antibiotic resistance and adverse effects. Natural sources such as plants may serve as promising alternatives. Methods: Compounds were isolated from the South...
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Ethnopharmacological relevance South Africa has a very rich flora. Many of these species such as those in the Cucurbitaceae family are exploited as medicines for the treatment of various infections. Aim of the review The aim of the review was to synthesize the existing but scattered literature of some plant species in the Cucurbitaceae family used...
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Symbiotic associations between endophytic fungi, hereon referred to as mycoendophytes, and their hosts involve several metabolic and regulatory processes. The exact molecular signal mechanisms that underlie these interactions are largely unidentified. Nevertheless, phytohormones seem to play key roles in the establishment and perpetuation of these...
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Medicinal plants used for wound healing and skin diseases are key to unlocking the doors to combating resistance of pathogens to pharmaceuticals and allopathic management. This study was aimed at screening the antioxidant effects, the anti-inflammatory activity and wound healing capacity of traditional medicinal plants used in the treatment of skin...
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Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract...
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Due to global warming, a permanent rainfall deficit and higher temperatures reduce the available water in the soil, which severely influences plant water status. Current research needs to address ways to overcome these problems in order to maintain crop yields. The beneficial effects of seaweed extracts against abiotic and biotic stress factors of...
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The progression of age and dark spots on human skin is undesirable as it indicates the reduction of skin beauty. The melanin produced by melanocytes is responsible for the associated darkening of the skin. Tyrosinase modulates the melanogenesis process and is a therapeutic target for skin disorders such as hypopigmentation and hyperpigmentation. Th...
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A hormonal network regulates growth processes and stress responses in vascular plants. There is evidence for a similar hormonal network in microalgae. This study investigated the effect of exogenous gibberellins (GAs)on Chlorella minutissima Fott et Nováková growth and biochemical composition. Two bioactive GAs i.e. GA 3 and GA 4 were applied at 10...
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Cosmetic products are directly and indirectly applied to the skin in order to enhance its beauty. Cosmetic products that are directly applied to the skin include creams, lotions and soaps while tablets and supplements are indirectly administered to achieve similar benefits. The aim of the current study was to investigate the cosmetic potential of p...
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A study was conducted to assess variation in antioxidant, antimicrobial, antidiabetic and phytochemical properties between the leaves, and the main and lateral roots of Moringa (Moringa oleifera). Standard antioxidant models including the DPPH scavenging, ferric reducing power (FRAP) as well as α-glucosidase inhibitory activity were used to evaluat...
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Certain grass species are used as remedies against diseases and as nourishing food for both humans and livestock. The review aims to explore the grasses used in South African traditional medicine and highlight their pharmacological and phytochemical properties as well as safety. Chemical compounds were drawn using ChemDraw Ultra 7.0, structures wer...
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Proliferation of acute inflammation under pathological conditions makes targeting the pro-inflammatory enzymes a therapeutic intervention. The inflammation process contributes significantly to the appearance of the skin as a result of scarring and dark spots that develop. Inflammation is a normal physiological process employed to remove tissue dama...
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Analysis of the bioactivity of ex vitro-grown micropropagated plants of a vulnerable traditional medicinal plant, Aloe pruinosa Reynolds, is essential to promote the supplementation of wild resources. Two-year-old ex vitro-acclimatized plants of A. pruinosa, established using different plant growth regulators and greenhouse-grown in vitro and in vi...
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An ethnobotanical survey was undertaken from May 2015 to May 2016 to identify grasses used in traditional medicine in KwaZulu-Natal, South Africa. Indigenous knowledge was obtained from sixty traditional healers through questionnaires and face-to-face interviews. Thereafter, the different grass species were collected and identified at the herbarium...
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Alien invasive plants pose a huge threat to natural and semi-natural ecosystems in their introduced ranges thereby compromising ecosystem integrity. However, anecdotal and empirical evidence suggests that some invasive alien plants are used in traditional medicine due to their pharmacological activities. Here, we evaluated the antimicro-bial activi...
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Paeonia ostii var. lishizhenii, a well-known medicinal and horticultural plant, is indigenous to China. Recent studies have shown that its seed has a high oil content, and it was approved as a novel resource of edible oil with a high level of α-linolenic acid by the Chinese Government. This study measured the seed oil contents and fatty acid compon...
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The side effects of skin disease antibiotics and lengthy periods of therapy are major shortcomings of both old and newly developed ranges of antifungals. Hence, there is a need to develop an effective, cheap and readily available antifungal of a natural origin to combat skin diseases. The aim of this study was to investigate the effect of Agathosma...
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There is the age-old saying, “where there is smoke, there is fire”, and while the important effects of fire as an ecological driver has been well known, and the effect of heat on seed germination previously well studied, it is amazing that it took until around 1990 for the “penny to drop” as far as the physiological effects of smoke on plant commun...
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Plant-derived smoke is known to play an important role in promoting germination in the post-fire environment, thereby stimulating regeneration of vegetation from the soil seed bank following a fire. Several compounds with germination promotory activity have been identified in recent years, with one such compound, 3-methyl-2H-furo[2,3-c]pyran-2-one...
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Extracts from Bolusanthus speciosus, Cucumis myriocarpus, Ekebergia capensis, Protea caffra, Prunus africana, Searsia lancea and Solanum panduriforme were screened for antigonococcal activity using microdilution and agar disk-diffusion techniques. In addition, combinations of the different plant extracts, as well as plant extracts with four antibio...
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Scadoxus puniceus (Amaryllidaceae), a medicinal plant of high value in South Africa, is used as a component of a traditional herbal tonic prescribed to treat several ailments. Ultra-high performance liquid chromatography–tandem mass spectrometry quantified the phenolic compounds in different organs of S. puniceus. Gravity column chromatography was...
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Infections of the central nervous system (CNS) of animals and humans by opportunistic pathogens such as bacteria and fungi remain a global health issue, resulting in high morbidity and mortality rates. This challenge is further complicated by the rise in resistant microbial strains as well as emergence of new infectious pathogens, especially in dev...
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Traditional medicine and the use of medicinal and aromatic plants in Africa are linked to social life, culture and daily activities of the African people. The celebration of life events involve the presentation and sharing of several culturally significant items such as honey, salt, Cola and other medicinal plants and their products. In this chapte...
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This study investigated the effects of smoke-water (1:500 v/v) and karrikinolide (KAR1) (10-7 M) on seed germination and seedling growth of a multipurpose tree species, Bauhinia variegata. The species is used for food, fodder, apiculture, fuel, fibre, timber, gum, tannin, medicine and ornamental purposes. Both treatments showed a significant increa...
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Bovine mastitis, a disease caused by inflammation of the udder, is one of the major causes of global dairy industry losses. Alternative therapies such as ethnoveterinary medicine are worthy of further study since mastitis-causing bacterial pathogens are becoming increasingly resistant to conventional antibiotic therapy. Plant species were selected...
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The unexplored southern African red marine alga Laurencia natalensis was studied in a search for new enzyme inhibitors. A new cuparane sesquiterpenoid, 8-deoxyalgoane (1) along with two known sesquiterpenoids namely 1-deacetoxyalgoane (2) and algoane (3) were isolated from the MeOH:DCM extract using silica column chromatography with an hexane:EtOAc...
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The potential agricultural or horticultural use of ‘smoke technology’ has received considerable attention since plant-derived smoke-water or smoke-derived compounds can play an intriguing role in seed germination and seedling vigor. However, it is of major importance to investigate whether such treatments may play a detrimental role in the genetic...
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Available online xxxx Edited by V Steenkamp Sexually transmitted infections (STIs), including opportunistic infections associated with HIV/AIDS, are amongst the leading causes of death, especially in poor countries. Acetone, aqueous, methanol, chloroform and ethyl acetate extracts from six ethno-botanically selected medicinal plants belonging to fi...
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The prolonged exposure of the skin to sun radiation can have undesired consequences, resulting in skin damage and darkening. Plant extracts that can offer protection to the skin are important in skin rehabilitation. Therefore, the aim of the study was to test plant extracts for their phytochemical potential and cosmetic importance. Extracts of 15 m...
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Micropropagation is an important tool for the conservation of threatened and commercially important plant species of which orchids deserve special attention. Ansellia africana is one such medicinally important orchid species having much commercial significance. However, for large-scale micropropagation to become not only successful but also accepta...
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A global North–South divide in research, and its negative consequences, has been highlighted in various scientific disciplines. Northern domination of science relevant to climate change policy and practice, and limited research led by Southern researchers in Southern countries, may hinder further development and implementation of global climate cha...
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Genetic manipulation or metabolic engineering in plants has resulted in the ability to control plants with the aim to synthesize desired plant secondary metabolites for the pharmaceutical and nutraceutical industry. The evolution of “omics” has further provided advanced resources that allow for elucidation of uncharacterized biosynthetic pathways,...
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Ansellia Africana Lindl., the “Leopard orchid” is a species endemic to Africa. Its ethnobotanical usage has been documented in various traditional African pharmacopeias. It has activity on the Central Nervous System (CNS) and has shown potentiality in the treatment of Alzheimer’s disease. However, due to overexploitation and habitat destruction, th...
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Exposure of seeds to optimum concentrations of smoke-water, karrikinolide and gibberellic acid promotes germination in many plants. The present study investigated the possible mechanism by which this is achieved. The activities of some hydrolytic enzymes (amylase, invertase and protease) as well as antioxidant enzymes (peroxidase, superoxide dismut...
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Swertia chirayita (Gentianaceae), a popular medicinal herb indigenous to the temperate Himalayas is used in traditional medicine to treat numerous ailments such as liver disorders, malaria, and diabetes and are reported to have a wide spectrum of pharmacological properties. Its medicinal usage is well-documented in Indian pharmaceutical codex, the...
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Commercial application of micropropagation techniques has predominantly been limited by factors such as high production costs as a result of undesirable growth rates in vitro and high labour costs. The present study aimed to establish a rapid, efficient and cost-effective micropropagation protocol for Z. aethiopica. Both rhizome and leaf explants w...