J M Rosés’s research while affiliated with University of Barcelona and other places

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Publications (4)


FIG. 2. NAD1/NADH content in blood mononuclear cells (BMCs) from chronic fatigue syndrome (CFS) patients at baseline and after 8 weeks of treatment. (A) NAD + levels, (B) NADH levels, and (C) NAD + /NADH ratio were measured as noted in the Notes section. Data represent the mean -SD of duplicate separate assays. *p < 0.001 significant differences between before and after 8 weeks of treatment.
Fatigue Index in 73 CFS Patients Based on Symptoms Assessment Questionnaire
[Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome].
  • Article
  • Full-text available

June 2010

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1,122 Reads

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23 Citations

Revista Clínica Española

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J M Rosés

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T Fernández de Sevilla

Nicotinamide adenine dinucleotide (NADH) may be depleted in chronic fatigue syndrome (SFC). The purpose of the study was to evaluate the efficacy of supplementation with NADH in these patients. A double blind, placebo controlled, 3 month long clinical trial was conducted. The patients were randomized to oral NADH oral 20mg or placebo during the first two months. The intensity of the fatigue, functional performance, mood state, functional impact of the fatigue, quality of life, sleep quality, exercise capacity and functional reserve as well as the investigator's and patient's opinion on the efficacy of the intervention prior to and at 30, 60 and 90 days of the onset of the treatment were evaluated. A stress test was performed in the baseline visit and at 60 days (last day of the double blind treatment). A total of 86 patients, 77 of whom completed the study (mean age, 47 years, 72 women) were enrolled. No significant differences were found in most of the variable studied at the end of the study. Administration of NADH was associated to a decrease in anxiety condition of -1.0 points (p<0.05) and of -0.2 points (p=NS) in the placebo assigned group. Maximum heart rate after the stress test decreased a mean of -8.1l/min (p<0.05) in the NADH group and increased by +1.7l/min in the placebo group (p=0.73). No differences were found in the perception of efficacy with NADH and placebo, by the investigator and patients. Administration of oral NADH was associated to a decrease in anxiety and maximum heart rate, after a stress test in patients with CFS. On the contrary, this treatment did not modify other clinical variables and the global functional performance.

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FIGURE 1 Physical test protocol. 
FIGURE 4 Meters covered in the last 20 min of exercise ( * p < .05). 
Figure 3 of 3
L-Tryptophan Supplementation Can Decrease Fatigue Perception During an Aerobic Exercise with Supramaximal Intercalated Anaerobic Bouts in Young Healthy Men

May 2010

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916 Reads

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24 Citations

The International journal of neuroscience

Physical exercise is often terminated not due to muscle fatigue but because of inadequate neural drive in the serotonergic system. Modifications in activity levels of the serotonergic system, induced by variations in the availability of L-tryptophan (a serotonin precursor) may alter neural drive. We examined the effect of L-tryptophan supplementation on physical performance by combining aerobic work with brief periods of supramaximal intensity that closely mimics the activity typical of team sports. Twenty healthy young sportsmen (mean age 21.2 +/- 0.7 years) performed a submaximal exercise on a cycle ergometer, with a workload corresponding to 50% of their respective VO(2) max for 10 min, followed by a maximal intensity exercise for 30 s. This sequence was repeated three times and, after the fourth series, each participant continued to exercise at the highest speed that he could sustain for 20 min. This protocol was performed twice: once with and finally without supplementation of L-tryptophan, in random order and double-blind. Peak power output, average anaerobic power output, and power output during the last 20 min of the trial were higher on the trials performed with L-tryptophan supplementation than on those performed with placebo. The distance covered during the last 20 min of the trial was 11,959 +/- 1,753 m on placebo and 12,526 +/- 1,617 m on L-tryptophan (p < .05). In conclusion, in some types of exercises, modification of the serotonergic system may improve the physical performance.


Citations (3)


... Our study supports the conclusion from previous reports suggesting the implication of mitochondrial dysregulation in the pathogenesis of COPD/emphysema [54] and a pivotal role of cigarette smoke in inducing oxidative damage in the lungs as a result of perturbating mitochondrial function [8]. Manipulating NADH levels by pharmacological agents has the potential to restore mitochondrial respiration and showed promising results in the treatment of diabetes and multiple disorders [15], chronic fatigue syndrome [16], and neurodegenerative diseases [17,18]. NAD treatment reduced the activation of circulating immune cells through the blockage of NLRP/3 inflammasome formation and inflammatory cytokine production. ...

Reference:

NADH Intraperitoneal Injection Prevents Lung Inflammation in a BALB/C Mice Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Nicotinamida adenina dinucleótido (NADH) en pacientes con síndrome de fatiga crónica
  • Citing Article
  • June 2010

Revista Clínica Española

... 23,24,30,32,33 Three trials assessed reduced nicotinamide adenine dinucleotide (NADH) against placebo. 26,28,29 Two trials assessed nicotinamide mononucleotide (NMN) against placebo. 40,41 One trial assessed nicotinamide (NAM) against placebo. ...

[Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome].

Revista Clínica Española

... Another scarcely explored possible health benefit of TRP seems to pertain to physical exercise and performance. In fact, TRP supplementation has been observed to improve physical performance in aerobic exercise with supramaximal intercalated anaerobic bouts in 20 young healthy men, possibly because of serotoninergic modifications in neural drive [91]. When it comes to the safety of TRP supplementation, there are a few considerations to make. ...

L-Tryptophan Supplementation Can Decrease Fatigue Perception During an Aerobic Exercise with Supramaximal Intercalated Anaerobic Bouts in Young Healthy Men

The International journal of neuroscience