January 1998
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117 Reads
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572 Citations
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January 1998
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117 Reads
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572 Citations
... A significant amount of preclinical and clinical research has been performed to scientifically underpin the traditional use of Crataegus in the treatment of heart failure; the first clinical trials date back to the 1990s [4,7,[22][23][24][25][26][27][28][29][30]. Leaf and flower extracts have been approved by the German Commission E for cardiac failure stage II according to the New York Heart Association (NYHA) [31,32]. The same indication is included in the monographs of the European Scientific Cooperative on Phytotherapy (ESCOP), on hawthorn leaf and flower [33] and hawthorn berries [34], and in the monograph of the World Health Organisation (WHO) [35]. ...
January 1998