J. Dickerman's research while affiliated with University of Illinois at Chicago and other places

Publications (2)

Article
Full-text available
Two dextran-binding myeloma proteins, J558 and Hdex 24, which possess the same individual idiotype (IdI) were diazotized to low levels (1-3.3 groups per subunit) with 1-[14C]-p-aminobenzoate. Both proteins lost the IdI idiotype under these conditions with most of the label incorporated on the heavy chains of each protein. When the diazotization ws...
Article
Two dextran-binding myeloma proteins, J558 and Hdex 24, which possess the same individual idiotype (IdI) were diazotized to low levels (1-3.3 groups per subunit) with 1-[14C]-p-aminobenzoate. Both proteins lost the IdI idiotype under these conditions with most of the label incorporated on the heavy chains of each protein. When the diazotization ws...

Citations

... This is likely due to the preponderance of tyrosine residues in amino acid position 101 (Y101) in CDR-H3 sequences isolated from plasmablasts of DEX-immunized DD-DmFS mice. Previous reports showed that the capacity of EB3-7 Ab (anti-J558 Id Ab) to bind J558 was diminished if this tyrosine residue was chemically modified (35). This specific affinity of EB3-7 to bind Y101 may explain the higher levels of J558 Id expression in the serum of DD-DmFS DEX-immunized mice. ...