J Deckert’s research while affiliated with Deutsche Gesellschaft für Psychiatrie, Psychotherapie, Psychosomatik und Nervenheilkunde  and other places

... The nNOS, the important enzyme responsible for the onset of erection, is encoded by the NOS1 gene [25], which has functional polymorphisms, including rs41279104 [13,26,27] and rs2682826 [28,29]. Polymorphisms of this enzyme have also been associated with an altered response to sildenafil in ED [13] and the increased risk of psychiatric illnesses such as schizophrenia [30,31], depression [32] and suicidal behavior [29]. ...

Reference:

The rs2682826 Polymorphism of the NOS1 Gene Is Associated with the Degree of Disability of Erectile Dysfunction

... Another study reported an association between a common NOS1 polymorphism and a death by suicide in males (Cui et al., 2010). Regarding possible intermediate phenotypes, NOS1 and NOS 3 polymorphisms, for instance, have also been shown to be implicated in cortisol levels, working memory performance, anxious apprehension, impulsivity, and aggression, possibly via its effect on prefrontal cortex, a key brain region involved in impulse inhibition, oxygenation (Kopf et al., 2012;Kuhn et al., 2016;Roth et al., 2019;Rujescu et al., 2008). These evidences further support the notion that NOS risk genotypes might predispose individuals to maladaptive stress and cognitive responses in face of adversity. ...

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Combined effects of nitric oxide synthase 3 genetic variant and childhood emotional abuse on earlier onset of suicidal behaviours

... Environmental factors contributing to its development include viral infections, sex hormones, diet, and stress (2). Several studies have proposed that childhood traumas can lead to hypothalamicpituitary-adrenal (HPA) axis dysfunction in adulthood, which in turn predisposes individuals to autoimmune diseases (3)(4)(5)(6). Exposure to adversities is considered a major condition for enduring alterations in HPA axis biology and increased sensitivity to trauma-related symptoms (7). Given that the HPA stress response axis undergoes maturational changes throughout childhood and adolescence, it may be particularly sensitive to childhood adversity, resulting in long-term and persistent dysregulation of the HPA pathway (8,9). ...

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The Role of Childhood Traumas in Adult Hashimoto’s Thyroiditis

... Almost three-quarters of the included studies were cohort studies and were conducted in the US (38/53) and mostly compared MetS prevalence between Non-Hispanic Whites/ White, Non-Hispanic Black/African American and Hispanics/ Mexican American ( [90,91] and one each in Germany [92], Sweden [93] and France [94]. All the studies apart from three [71,78,84] applied random sampling methods. ...

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Ethnic differences in metabolic syndrome in high-income countries: A systematic review and meta-analysis

... B. therapeutische und dosisbezogene Referenzbereiche für 154 Arzneimittel, Indikationen und reevaluierte Empfehlungsgrade für den Gebrauch von TDM, Übersichten über Cytochrom-P450-Substrat-, -Inhibitor-und -Induktor eigenschaften der Psychopharmaka, Darstellung der normalen Bereiche von Quotienten von Metaboliten zu Muttersubstanzen) und es wird ein konkreter Handlungsleitfaden für die Praxis einschließlich anschaulicher Fallvignetten gegeben. Diese Leitlinien wurden international empfohlen Zeng et al., 2020) und es gibt sie auch in deutscher (Hefner et al., 2018) ...

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Therapeutisches Drug Monitoring zur Optimierung der Psychopharmakotherapie von Kindern und Jugendlichen: Update und Leitfaden für die Praxis

... При сравнении 43 пациентов с ХСН ишемического генеза и 140 здоровых лиц частота генотипа TNF-α-238A / A была значительно выше у пациентов с ХСН, но различий частот аллелей и генотипов ИЛ-6 не выявлено (ФВ ЛЖ авторы не контролировали) [5]. В другом исследовании рецессивные генотипы двух однонуклеотидных полиморфизмов гена С реактивного белка (СРБ) (rs1800947 и rs11265263) были связаны с более высоким риском смерти и более высокими уровнями СРБ, но полиморфизм гена ИЛ-6 не был связан со смерт ностью [8]. ...

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Inflammatory Biomarkers in Patients With Type 2 Diabetes Mellitus and Heart Failure With Preserved Ejection Faction

... There is a consensus on the therapeutic range for both ARI (100-350 ng/mL) and active moiety (AM) (sum of ARI AND DHA) (150-500 ng/mL) 4 . Considering that there is available a target plasma concentration and the evidence that exists on the influence of the metabolizing state of CYP2D6 and CYP3A4 on these concentrations (dose recommendations included in Summary of product characteristics), the influence on aripiprazole plasma concentrations of another important player in the pharmacokinetics of numerous drugs in the body, P-Glycoprotein (P-gp), needs to be further explored. ...

Reference:

Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations

... Physical interventions and the use of rodenticides can be particularly difficult to implement, due to difficulties intrinsic to rodent physiology and behavioural adaptations. Most pest rodent species show signs of neophobia (Ennaceur et al. 2008;Modlinska et al. 2015;Raab et al. 2018;Witmer et al. 2020;Vicente & De la Casa 2021), both towards novel objects and tastes, which results in high levels of "trap-shyness" (Weihong et al. 1999;Herawati & Purnawan 2019), and low bait acceptance (Brunton et al. 1993;Shumake et al. 2002;Bedoya-Perez et al. 2021). Rodents also learn from the experience of conspecifics; if conspecifics emit signals of distress, e.g., getting caught in a trap as they are less likely to approach the same area later on (Brudzynski & Chiu 1995;Brudzynski 2009;Haapakoski et al. 2018). ...

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Field Efficacy of Anticoagulant Rodenticide Towards Managing Rodent Pests in Jitra Rice Field, Kedah, Malaysia

... Lubbers et al. demonstrated that mindfulness-based cognitive therapy (MBCT) significantly reduced rumination and negative intrusive thoughts in BD patients (Lubbers et al., 2022). Furthermore, van den Berg et al. reported a significant reduction in depressive symptoms, anxiety, hopelessness, and intrusive and problematic imagery after a four-week intervention using imagery-based cognitive therapy ( (Deckersbach et al., 2010;Preiss et al., 2013;Veeh et al., 2017). Different techniques and approaches were used in these interventions, including cognitive-behavioral therapy (CBT), lifestyle modifications, coping strategies, psychosocial skills, and role-playing (Veeh et al., 2017), and Deckersbach et al. used CBT in their protocols (Deckersbach et al., 2010) (Table 2). ...

Reference:

Cognitive rehabilitation in bipolar spectrum disorder: A systematic review

... We combined data from the Recurrent Unipolar Depression (RUD) study, a cross sectional case-control study on patients with recurrent unipolar depression and control subjects [29] and the Munich Antidepressant Response Signature (MARS) project with subprojects MARS-Depression, a prospective multi-centre naturalistic observational study of treatment outcomes in acutely depressed in-patients [30], MARS-Anxiety, a study consecutively recruiting from the Anxiety Disorders Outpatient Clinic at the Max Planck Institute of Psychiatry (MPIP) [31], and MARS-Controls, a population cohort study randomly selected from the Munich resident's registry [32]. The RUD and the MARS project were approved by the respective responsible Ethics Committee of the Bayerische Landesärztekammer and the Ludwig Maximilian University of Munich, Germany. ...

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Huntingtin CAG repeat size variations below the Huntington’s disease threshold: associations with depression, anxiety and basal ganglia structure