J. Cooke's research while affiliated with MRC National Institute for Medical Research and other places

Publications (2)

Article
Most current models for morphogenesis of repeated patterns, such as vertebrate somites, cannot explain the observed degree of constancy for the number of somites in individuals of a given species. This precision requires a mechanism whereby the lengths of someites (i.e. number of cells per somite) must adjust to the overall size of individual embry...

Citations

... Studies on temporal control of cell cycle progression, circadian rhythm, and segmentation have frequently converged on the concept of biological oscillators [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Biological oscillators are systems of molecules with various levels of expression and activity that act as molecular "clocks" that determine biological rhythms resilient to changes in external environments. ...
... It has been established that segmentation in most arthropods and all vertebrates is driven by a cyclical mechanism where the temporal periodicity of a clock is translated into a repetitive spatial pattern (Cooke and Zeeman, 1976;Palmeirim et al., 1997;Sarrazin et al., 2012). In vertebrates, cell-autonomous oscillatory genes expression is maintained by a posterior Wnt + Fgf signaling gradient. ...