J. Cooke's research while affiliated with MRC National Institute for Medical Research and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (2)
Most current models for morphogenesis of repeated patterns, such as vertebrate somites, cannot explain the observed degree of constancy for the number of somites in individuals of a given species. This precision requires a mechanism whereby the lengths of someites (i.e. number of cells per somite) must adjust to the overall size of individual embry...
Citations
... Studies on temporal control of cell cycle progression, circadian rhythm, and segmentation have frequently converged on the concept of biological oscillators [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Biological oscillators are systems of molecules with various levels of expression and activity that act as molecular "clocks" that determine biological rhythms resilient to changes in external environments. ...
... It has been established that segmentation in most arthropods and all vertebrates is driven by a cyclical mechanism where the temporal periodicity of a clock is translated into a repetitive spatial pattern (Cooke and Zeeman, 1976;Palmeirim et al., 1997;Sarrazin et al., 2012). In vertebrates, cell-autonomous oscillatory genes expression is maintained by a posterior Wnt + Fgf signaling gradient. ...
