J. Bailey’s research while affiliated with University of Iowa and other places

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Publications (5)


MRI-based parcellation of the frontal cortex: Topographic tracing guidelines and reliability
  • Article

January 1999

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6 Reads

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J.J. Kim

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N.C. Andreasen

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[...]

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An MRI study of the corpus callosum in autism

September 1997

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550 Reads

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341 Citations

American Journal of Psychiatry

The purpose of this study was to examine the size of subregions of the corpus callosum in autistic individuals. The areas of three subregions (anterior, body, and posterior) of the corpus callosum were examined on midsagittal magnetic resonance images of 35 autistic subjects whose mean age was 18 years and 36 healthy comparison subjects matched on age and IQ. After controlling for total brain volume, gender, and performance IQ, the authors detected a significantly smaller size of the body and posterior subregions of the corpus callosum in the autistic individuals. In the context of recent reports of increased brain size in autism, several possible mechanisms are considered in exploring the significance of a smaller relative size of the corpus callosum in autism.



An MRI study of brain size in autism

September 1995

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116 Reads

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426 Citations

American Journal of Psychiatry

This study was undertaken to obtain detailed measurements of the volume of the brain, using magnetic resonance imaging (MRI), in a carefully selected group of autistic subjects and comparison subjects. Twenty-two male autistic subjects and 20 male volunteer comparison subjects were examined with detailed (1.5-mm slices) MRI throughout the entire brain. Total brain, total brain tissue, and total lateral ventricle volumes were measured by using manual tracing and automated techniques. After height and performance IQ were controlled, autistic subjects had significantly greater total brain, total tissue, and total lateral ventricle volumes than comparison subjects. These findings suggest that male autistic subjects have enlarged brains and that enlargement is a result of both greater brain tissue volume and greater lateral ventricle volume.

Citations (4)


... Indeed, recent association studies for schizotypy have failed to identify correlations with total hippocampal volume per se [92], while subfield analyses do report effects on particular subregions related to subclinical psychotic-like features [20]. Moreover, studies have found increased [83,84], decreased [93] and no association [94,95] of hippocampal volumes with ASD. One potential source for this inconsistency in results is variation of unmeasured cooccurring subclinical expressions. ...

Reference:

Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow
Erratum: No difference in hippocampus volume detected on magnetic resonance imaging in autistic individuals (Journal of Autism and Developmental Disorders 28:2 (105-110))
  • Citing Article
  • June 1998

Journal of Autism and Developmental Disorders

... Extracranial tissue was removed using edge detection techniques and manual tracing. The pixels representing the measures of GM, WM and cerebral spinal f luid (CSF) were identified using a multispectral discriminant analysis-based segmentation algorithm applied to the three image sequences described above (T 1 , T 2 , PD) (Harris et al., 1997(Harris et al., , 1999. The segmentation algorithm provides both a discrete classification of tissue into GM, WM and CSF and a continuous classifier that contains partial voluming information. ...

Improving tissue segmentation in magnetic resonance imaging: multiple pulse sequences and automated training class selection
  • Citing Article
  • January 1997

... The theory of evolution is in accordance with the changes in brain weight which have been deduced from archaeological findings in the progression from early to present humans -see Figure 3. Historically measurements of brain weight were related to states of health such as tuberculosis and various types of mental disorder [2]. More recently increased brain size has been found in autism [7,8,9] where white matter volume was increased by 50% more than gray matter in infants [9]. ...

An MRI study of brain size in autism
  • Citing Article
  • September 1995

American Journal of Psychiatry

... Previous studies have reported abnormal frontal and temporal lobe growth, altered grey matter, white matter, and amygdala volume in young children with ASD, consistent with current findings [61]. Research in individuals of all ages with ASD has shown both increases and decreases in cortical thickness [62]. For instance, Piven et al. observed reduced cortical thickness in various brain regions, while Hardan et al. found thicker cortical layers in individuals with ASD [63]. ...

An MRI study of the corpus callosum in autism
  • Citing Article
  • September 1997

American Journal of Psychiatry