J. Alba Dominguez's scientific contributions

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Publications (2)

A Multi-Method Analysis of c-erbB2/HER2 in FFPE Tissue: Correlation of a Novel and Rapid In Situ Hybridization Procedure, HER2 CISH and IHC.:
Article
  • Dec 2009
Background: Overexpression of HER2/neu gene or protein is found in 20% to 30% of breast carcinomas and is predictive of response to treatment by trastuzumab. Methods such as FISH or CISH determine gene amplification status, however, amplified genes may or may not be all transcribed at equivalent levels. Recently, a new c-erbB-2 probe for rapid in s...
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Citations

... It uses a peroxidase enzyme-labeled probe for chromogenic detection using diaminobenzidine [55]. Meanwhile, some new methods (HER2-V2, MLPA, NGS, RISH) are also in clinical trials and have yet to be approved by FDA [57][58][59][60][61]. They showed good superiority: more accurate patient stratification, fast and inexpensive, need a tiny amount of DNA, and identify mutations in HER2 segments [59][60][61][62][63]. ...
Reference: Research progress of antibody-drug conjugates therapy for HER2-low expressing gastric cancer
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