J A Dormandy’s research while affiliated with St. James University and other places

... In approximately 14-20% of patients diagnosed with changes affecting small peripheral arteries, angiographic examination reveals occlusion of arteries without patent distal vessels, which excludes the possibility of reconstructive treatment [34,35]. Venous arterialization is an option to improve the local condition and reduce ischemia in patients with diseases affecting the distal part of the arterial tree, in whom pharmacological therapy does not bring the intended effects [36]. ...

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Surgical Strategies in the Management of Raynaud's Phenomenon: Comparative Analysis of Trends and Effectiveness Incorporating New Clinical Data

... Although there are recommendations of International Committee for Measurements of Blood Viscosity (ICSH, 1986), the interpretation and comparison of clinical whole blood viscosity data are not satisfactory. This is because workers in this field generally, while reporting viscosity values have used one or two different particular shear rates (Walker et al 1985; Lechner et al 1986; Ott et al 1986; Caimi et al 1987; Ernst et al 1987; Fisher et al 1987). There has been no agreement about the shear rates at which the viscosity should be compared between two given samples (Inglis et al 1981). ...

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Relationship between power law coefficients and major blood constituents affecting the whole blood viscosity

... Arteriosclerosis obliterans of the lower limbs is caused by the formation of atherosclerotic plaques of the lower limbs, which leads to arterial stenosis and occlusion, leading to chronic limb ischemia. Percutaneous superficial femoral interventions are the preferred treatment for superficial femoral artery disease, even though the occurrence of in-stent restenosis (ISR) continues to be an important complication [1][2]. The mechanism of stent restenosis is unclear. ...

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The relationship between Neutrophi–Lymphocyte Ratio and in-stent restenosis in superficial femoral artery

... Approximately 50% of women and 20% of men report discomfort associated with varicose veins [5]. It is estimated that the annual cost of treating varicose veins in Western countries may exceed 2% of the total healthcare budget [6,7]. ...

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Invasive Treatment of Lower Limb Varicose Veins - Comparison of Treatment Methods

... Despite various attempts to improve the overall mobility and independence of the lower limb amputee, the result has been rather depressing (Dormandy and Ray, 1995; Collin and Collin, 1995). The majority of amputees belong to the dysvascular group and are aged. ...

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An audit of the quality of the stump and its relation to rehabilitation in lower limb amputees

... Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) parameters, their definitions, and their interpretations. This table also depicts the different ROTEM assays, their activators, and the differences among them[109][110][111][112][113]. ...

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Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests

... Dilatation and incompetence of the great saphenous vein leads to increased ambulatory venous pressure, microvascular ischaemia and cutaneous tissue breakdown. 1 Several factors affect tissue viability and susceptibility to ulceration, but the structural and functional integrity of the microcirculation to maintain blood flow, tissue oxygenation and nutrient delivery despite changes in systemic and local haemodynamics may be especially important. 2 For example, we have previously shown that cutaneous microvascular vasodilator responses in the perimalleolar region are impaired in the upright position in patients with isolated great saphenous vein incompetence compared with healthy controls. ...

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Contrasting Effects of Varicose Vein Surgery on Endothelial-dependent and -independent Cutaneous Vasodilation in the Perimalleolar Region

... One possible consideration for the observed frequency differences could be variations in the definition of restenosis or loss of clinical patency, as well as differences in the inclusion criteria. Although there are lingering concerns regarding the safety and efficacy of the SI approach for CTO lesions of the FP region 19 , the outcomes of SI have been enhanced through numerous advancements in techniques and devices 5,22 . Therefore, to date, there is no evidence favoring either the IL or SI route in terms of midterm results for BMS or drug-eluting devices 5,19 . ...

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Drug-coated balloon versus drug-eluting stent for femoropopliteal total occlusions: intraluminal versus subintimal approaches

... 17 Unfortunately, studies that permit its benefit to be quantified are not available, especially among the subgroup of patients with an acutely thrombosed PAA. 18,19 Therefore, the aim of this study was to investigate outcomes of intra-operative intra-arterial thrombolysis with tissue plasminogen activator (tPA) as a thrombolytic agent in the treatment of acute PAA thrombosis Rutherford grade IIa and IIb in terms of major adverse limb events (MALE), overall survival, and intrahospital complications, especially those associated with bleeding. ...

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Effect of Intra-operative Intra-arterial Thrombolysis on Long Term Clinical Outcomes in Patients with Acute Popliteal Artery Aneurysm Thrombosis

... These results argue against a putative role for pioglitazone in development of bladder cancer. Further, overall incidence of malignancy has been reported not to increase (106) or decrease in certain cancer types (breast and liver) in pioglitazone-treated patients (188,(190)(191)(192). Lastly, any increased bladder cancer risk must be viewed in the context of protection against all-cause death, MI, and stroke, i.e., MACE end point in PROactive. ...

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In Vivo Actions of Peroxisome Proliferator-Activated Receptors: Glycemic control, insulin sensitivity, and insulin secretion