Ivar Aursnes's research while affiliated with University of Oslo and other places

... The most frequently identified PIMs with both tools were hypnotics, and zopiclone in particular. Nearly 30% of our study population used zopiclone ≥3.75 mg after hospitalisation (Table 2), a result supported by other Norwegian studies [26]. Given the considerable evidence relating hypnotics to ADEs in older adults, the widespread use of zopiclone is alarming, and interventions are warranted [27]. ...

... [27][28][29] Other trials also reported a tendency toward reduced benefit from ACE inhibition among patients taking ASA, although the existing data are still controversial and inconclusive. [29][30][31] Nguyen et al 32 conducted a retrospective subgroup analysis of data from the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II) and showed that the enalapril-ASA interaction was a significant predictor of mortality at the end of the study, and thus concluded that the effect of enalapril therapy was less favorable among pa-tients taking ASA than among patients not taking ASA at baseline. At the same time, the authors did not find a significant interaction with regard to nonfatal major events. ...

... With regard to relapse, clozapine appears to be superior to FGAs long-term [79,125], but evidence from meta-analyses is inconsistent [64] (see Fig. 2H). With regard to response, clozapine appears to be superior to placebo with large effect sizes [57,66], superior to FGAs short-term with small effect sizes [48,99,106,125], but not superior to single SGAs (e.g. quetiapine, risperidone, olanzapine) [29,30,61,67,70,122] (see Fig. 2G). ...

... 13 86 88 Few reviews focus on primary care (ie, general/ family practice and outpatients). 67 68 71 72 83 89 While some reviews combine primary and secondary care inpatient studies, 23 use of data on file, which misses search strategies and misses references, preventing others from replicating the review 56 66 75 76 81 ; assessing and reporting on efficacy but not on adverse effects or dropout rates 18 20 56 59 61 64-67 69 74 76 78-81 83 ; and assessing response without reporting remission effects. However, even after considering the potential limitations of previous reviews, this systematic review of reviews and meta-narrative synthesis shows an overall consensus that SSRIs demonstrate a flat doseresponse effect for efficacy, and poorer acceptability and tolerability as SSRI doses are increased for the treatment of depression. ...

... Once in the blood stream, ADP can cause platelet activation. A reversible platelet aggregation has been shown upon ADP infusions in rats and rabbits [36,37]. There are studies in rats demonstrating administration of Hb associated with various molecules, leading to increased platelet aggregation and adhesion in vivo on prothrombotic surfaces such as an injured vessel wall. ...

... The best of three trials was selected for calculations. Exercise test was performed in a temperature-controlled exercise laboratory at 22°C using a bicycle ergometer (Monark, Ergomedic 818, Sweden) and the Bruce protocol [9]. The test began with no load (zero watts). ...

... Coagulation factors, specifically fibrinogen and factor VII, (serum prothrombin conversion accelerator) have been implicated as risk factors for atherosclerotic diseases (Wilhelmsen et al., 1984;Meade et al., 1986). Several cross-sectional studies also have suggested an association between factor VIII and von Willebrand factor (vWF) with atherosclerotic heart disease, but other studies have found no association with heart disease (Sugrue et al., 1985;Myreng et al., 1986). Thus, a reduction in the risk of CAD can be related to the prevention of clotting or thrombosis, especially because 90% of patients with fatal myocardial infarction have associated coronary thrombosis. ...

... Once platelets are activated by shear stress or ADP, they are less responsive to a subsequent stimulation. This phenomenon of desensitization has been proven for ADP and thrombin receptors on platelets [22,23]. In the present study, lower aggregation (AUC) in impedance aggregometry was observed after PTS transports independent of whether testing was conducted in the OR area by trained anesthesia personnel or the central laboratory by specialized laboratory personnel. ...

... Such statistical adjustment is these studies observed an increased CHD risk in patients treated with a calcium antagonist 38 and two likely to be incomplete due both to the error with which confounding factors (such as disease history did not. 39,40 Among those not reporting an increase in risk, one included about 200 cases and 800 con-or risk factor levels) were measured and to the limited number of potential confounding factors for trols 39 and the other included about 100 cases and 300 controls. 40 Both of these studies were too small which data were available (eg typically, little data were available about evidence of subclinical athero-to detect even a doubling in the risk of CHD with calcium antagonists. ...

... Total fat intake may theoretically influence haemostasis indirectly through effects on blood lipoproteins. Serum or plasma triacylglycerol concentration is positively associated with factor VII, (Miller, 1993), bleeding times (Mundal et al. 1994) and with tPA and PAI-1 concentrations (Is0 et al. 1993a). Factor VII, also correlates with apolipoprotein B levels (Vaisanen et al. 1995). ...