Isabel Arrieta-Cruz's research while affiliated with Instituto Nacional De Geriatría and other places

... From an evolutionary perspective, immunosenescence can be looked upon as an adaptive process. Moreover, the immune system, alongside aging, develops low-grade, chronic inflammation, which results in systemic damage but not yet clinically detectable disease [58]. Low-grade inflammation is a contributor of gut microbiota variations, and its derived products and may trigger metabolic syndrome [59]. ...

... In addition, poor nutrition and reduced exposure to sunlight are commonly seen in institutionalised individuals -a population at a particularly high risk of deficiency [19]. It has been well-established that low serum 25(OH)D 3 levels are associated with reduced muscle strength [20][21][22][23][24][25][26][27] and impaired physical function [28][29][30][31][32][33][34]. Longitudinal studies indicate that deficiency may exacerbate the age-related decline in strength and physical performance [35][36][37][38][39][40][41][42] whilst also potentially acting as an independent risk factor for sarcopenia [40,43,44]. ...

... Ischemic strokes or cerebrovascular accidents are the most frequent types of cerebrovascular diseases and are one of the main causes of death and disability worldwide [44]. The main type of strokes is the focal ischemic, which is due to an obstruction of the arterial blood flow to a specific brain region [45]. Aging is considered to be the most important nonmodifiable risk factor, and the risk of a stroke occurring doubles every 10 years after the person reaches the age of 55, and approximately three quarters of all strokes occur in persons aged ≥65 years [46,47]. ...

... Several pieces of research have evidenced associations between dietary patterns and depression [28,29]. Malnutrition, in particular, has shown a direct independent association with depression, both in the general population and in specific groups [30,31]. With progression of the disease, cancer patients developed weight and BMI loss, with changes in dietary intakes of most nutrients, which result in energy intake deficiency, altered anthropometric indices, and poor nutritional status [32][33][34]. ...

... Gene expression of estrogen-related receptors and proteins was quantified as the observed differences in circulating E 2 could modulate their expression via negative feedback (49,50). ...

... Specifically, we found that very low and ineffective concentrations of DHM and BUT, when combined together, provided complete protection against SALS-induced toxicity. This is of clinical relevance given that the bioavailability of both DHM and BUT are rather low (Stilling et al. 2016;Li et al. 2017;Martínez-Coria et al. 2019), and hence, joint administration of low and/or non-effective doses of DHM and BUT, where each alone might exert a minimum effect, could potentially provide the desired neuroprotective outcome in a human subject. ...

... In a previous study, we showed that in diestrus-2, the specific blockade of both estradiol receptors in the right POA-AHA leads to the inhibition of ovulation in most of treated animals. Also, we proved that the number of ERα-and ERβimmunoreactive cells was significantly higher in the right POA-AHA at 09:00 h of proestrus and that the specific blockade of ERα or ERβ in the left POA-AHA inhibited ovulation in 84% of the animals (Arrieta- Cruz et al. 2019). Taken together, the results suggest that the positive feedback action of estradiol on POA-AHA on the secretion of gonadotropins varies along the estrous cycle and in proestrus occurs mainly in the right side of the hypothalamus, which is in line with the present study. ...

... Sarcopenia and anemia are both related to malnutrition and can lead to dysfunction and physical disability. Most studies of sarcopenia have focused on its association with infections, falls, and frailty [10][11][12]. ...

... Inhibit degranulation and cytokine secretion of RBL-2H3 and BMMC. Inhibit Syk activation; Ca 2+ independent [151,152]. ...

... The presence of M1 and M2 muscarinic receptors has been reported in the POA and the content of M2 receptor fluctuate in a daily pattern. Blockade of muscarinic receptors by selective antagonists results in a decrease or increase of the ovulation rate depending on the stage of the estrous cycle when blockade was performed [185]. ...