Iris Yaish's research while affiliated with Tel Aviv University and other places

... One study reported that 67.4% of transgender women and 61.6% of transgender men had a desire to parent a child, with 50% and 37%, respectively, desiring a biological one. 8 Thus, fertility counseling early in the transition process can aid in attaining these goals. Health care providers should be sure to discuss all options with patients prior to hormone therapy or surgical intervention. ...

... Despite the increase in research specific to trans individuals and pregnancy in recent years, there is still limited research on trans people's reproductive health and fertility for folks who have undergone hormone replacement therapy, gender-affirming surgeries, or both. Yaish et al. (2021) explored egg reserves in trans people who have a uterus and take testosterone for a period of time, ultimately finding that testosterone had no impact on the level of anti-Mullerian hormone (a predictor of ovarian reserve) in individuals taking testosterone and not previously diagnosed with polycystic ovary syndrome. Yaish et al. (2021) note that little research exists in this area, what does exist is contradictory, and future research, especially longitudinal studies, is sorely needed. ...

... Recent data revealed that low-dose cyproterone acetate (10−20 mg/d) suppressed testosterone level to a similar level compared with highdose (50−100 mg/d). 22 The present study revealed that lowdose cyproterone acetate is used in the real world, and more data is needed to prove its efficacy in testosterone suppression. ...

... Among them, the most important is the intervention at the level of the vascular endothelium [3,4], modifying the release and production of mediators and, secondarily, the functions of the receptor systems of signal conducting systems [3,5]. Another direction of influence is the influence on the function of blood platelets responsible for the progression of the disease and its exacerbations [6][7][8], as well as the growth of atherosclerotic plaques [9,10]. Cardiovascular diseases (CVD) are responsible for over 4 million deaths annually in Europe [11]. ...

... Interestingly, however, fibromyalgia remains more prevalent in transgender men compared to transgender women. Levit et al. [31] explained that this may be attributed to the exposure of the central nervous system to female hormones during development in-utero. Sex hormones during fetal development may have lifelong effects on pain perception even if patients are receiving hormone therapy during adulthood [31]. ...

... Sofer et al (7) observed that among their otherwise similar patients, those treated with CPA had prolactin elevations whereas those treated with either spironolactone or with a GnRH agonist did not. The observation is consistent with the finding suspected by U.S. and European investigators in isolation (8,9). ...

... 14,20 It has been hypothesized that perception of physicians of an illness consists of the same dimensions as the one for patients, yet it is based on academic knowledge and clinical experience. 1 Nevertheless, qualitative studies that explore physicians' personal pain concepts are scarce, especially for the treatment of children and adolescents with chronic pain. One study reported that physicians have 3 diverging perspectives about pain, ie, biological, professional, and personal perspectives. ...

... There was a slight but statistically significant difference in sodium concentration in the subset of transgender women taking spironolactone compared to those not taking spironolactone; in contrast, potassium concentrations were not significantly different between these groups. The impact on sodium concentrations is a known consequence of spironolactone impacting the mineralocorticoid system (38), although the magnitude of changes observed may not be clinically meaningful in many cases. However, the exclusion criteria in our study (e.g., diabetes, prior severe cardiovascular event) and relatively young age of the cohort likely reduced the number of subjects with factors such as administration of angiotensin converting enzyme or angiotensin receptor antagonist medications that may also impact the Transgender Clinical Chemistry Reference Intervals ARTICLE September 2022 | 07:05 | 1131-1144 | JALM mineralocorticoid system. ...

... An aspiring TOETVA surgeon should be a high-volume thyroid surgeon proficient in procedures of the central neck 52,53 , and be familiar with either laparoscopic or endoscopic surgery. Emerging retrospective data suggest that the learning curve is somewhere between 11 and 15 procedures 38,54 , although a larger learning curve of 25-30 operations has been reported for otolaryngologist-head and neck surgeons without previous experience in robotic or laparoscopic surgery 39 . Several recommendations have been published on how aspiring TOETVA surgeons should map their professional development and involvement with this technique 52,53 . ...

... Moreover, opposite changes occur in conditions resulting from thyroid hormone deficiency (12)(13)(14). However, only few studies have investigated dyslipidemia risk in patients with TC, and these have yielded conflicting results (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), possibly because of differences in the study population, sample size, and follow-up period. ...