Iris Yaish's research while affiliated with Tel Aviv University and other places

Publications (33)

Article
Background : the application of fertility preservation, initially intended for oncological patients prior to gonadotoxic treatment, has extended in recent years to transgender and gender-nonconforming individuals undergoing therapy for gender compatibility. Objectives : to examine semen quality and survival in transgender women pursuing semen cryo...
Article
Full-text available
Background: Transgender men are a marginalized population with unique health care needs. However, their usage of health services is low because of considerable discrimination. A major factor in their avoidance is patient-provider interactions. Methods: This cross-sectional study included 102 transgender men who anonymously completed a 55-item qu...
Article
Research question What are the fertility preservation (FP) rates of transgender women and transgender men, and which factors affect their decision making? Design This prospective study included 97 transgender women and 91 transgender men referred to the Gender Clinic of our medical center's Endocrinology Institute and to the Gan Meir Community Hea...
Article
STUDY QUESTION Is the functional ovarian reserve in transgender men affected by testosterone therapy? SUMMARY ANSWER Serum anti-Müllerian Hormone (AMH) levels slightly decrease during testosterone treatment but remain within the normal range, suggesting preserved follicular ovarian reserve. WHAT IS KNOWN ALREADY Few small studies have investigate...
Article
Full-text available
Elevated low-density lipoprotein (LDL) cholesterol is one of the leading causes of cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors reduce LDL cholesterol levels with subsequent reductions in cardiovascular morbidity. Elevated aldosterone levels are also associated with a greater risk of cardiovascular morbid...
Article
Background: Transgender women with intact gonads receive lifelong hormonal treatment to suppress physiologic androgen production, the optimal efficacious and safe cyproterone acetate (CPA) dose has not been established. Aim: To assess the effectiveness and safety of low-dose (10-20 mg/day) compared with high-dose (50-100 mg/day) CPA treatment....
Article
Full-text available
Background: Transgender individuals feel an incongruity between the assigned gender at birth and their gender identity. Because the prevalence of cardiovascular risk factors and morbidity associated with cross-sex hormonal therapy is not well established, particularly in the older transgender population, we set out to compare it to that of the gene...
Article
Objectives: As members of a gender minority, transgender individuals face many challenges. Many experience distress, depression, anxiety and suicidal ideation related to gender non-conformity and transphobia. Stress and trauma may contribute to the development of fibromyalgia (FM) syndrome, characterised by widespread pain and fatigue. The prevale...
Article
Objectives: Rheumatoid arthritis (RA) and fibromyalgia syndrome (FM) are common diagnoses encountered in rheumatology practice, but do not enjoy the same status. We aimed to examine physician's illness perceptions regarding these two rheumatologic disorders and to evaluate how they correlate with their relationship with these patients. Methods:...
Article
Full-text available
PurposeTo compare assisted reproductive technology (ART) outcomes among transgender men with those of fertile cisgender women.Methods This retrospective cohort study included 12 transgender men, six with no testosterone exposure and six after testosterone treatment, and 12 cisgender women (oocyte donors) who underwent ART in our institution between...
Article
Background: Transoral endoscopic vestibular approach (TOEVA) for thyroidectomy (TOETVA) and parathyroidectomy (TOEPVA) is gaining popularity, yet knowledge is based on a limited number of studies, mostly performed by surgeons experienced in laparoscopic\robotic surgery. Methods: All patients who underwent TOEVA at our institution between Februar...
Article
Full-text available
Background: The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the long-term all-cause mortality in TC survivors compared to the general population, and its association with cardiovascular risk factors. Methods: Individuals diagnosed with TC during 2...
Article
Objective: Suppression of testosterone secretion and/or action in transgender women using cyproterone acetate (CPA), spironolactone, or gonadotropin-releasing hormone analogues (GA) is achieved through various mechanisms. Our objective was to characterize possible differential effects of these compounds on metabolic and endocrine variables. Method...
Article
Objective: Suppression of testosterone secretion and/or action in transgender women using cyproterone acetate (CPA), spironolactone, or gonadotropin-releasing hormone analogues (GA) is achieved through various mechanisms. Our objective was to characterize possible differential effects of these compounds on metabolic and endocrine variables. Methods...
Preprint
Full-text available
Background: The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the association between long-term all-cause mortality and cardiovascular risk factors in TC survivors compared to the general population. Methods: Individuals diagnosed with TC during 2001...
Preprint
Full-text available
Background: The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the long-term all-cause mortality in TC survivors compared to the general population, and its association with cardiovascular risk factors. Methods: Individuals diagnosed with TC during 20...
Preprint
Full-text available
Background: The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the long-term all-cause mortality in TC survivors compared to the general population, and its association with cardiovascular risk factors. Methods: Individuals diagnosed with TC during 20...
Article
Full-text available
Introduction : Transgender women with intact gonads receive lifelong hormonal treatment in order to suppress physiologic androgen production. Cyproterone acetate (CA) is the most comon antiandrogenic drug prescribed for this indication in Europe, with a dose range between 25-100 mg/day. Aim: To assess the effectiveness and safety of low dose (<20 m...
Article
Research question What is the fertility preservation (FP) rate among transgender women who received professional fertility counseling compared to transgender men? Design This retrospective cohort study included 56 transgender women and 56 transgender men referred to comprehensive fertility counseling at the Gender Clinic of the medical center's Fe...
Article
Importance: Chondrolaryngoplasty or reduction of laryngeal prominence is a gender affirmation surgery for transgender women, or for male patients desiring an aesthetic surgery. Several variations of the procedure were suggested, yet to date, all described chondrolaryngoplasty procedures involved a visible neck scar. Objective: To describe a novel t...
Article
Background: Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown. Aims: To study markers of ovarian reserve during testosterone therapy. Methods: Prospective open-label study of transgender men prior and during treatment with testosterone. Sampling was c...
Article
Background and aim of study: Although gender dysphoria is no longer considered a mental illness, transgender people are at risk for psychopathologic morbidities. Endocrinologists play a central role in the gender-affirming process that transgender people chose to undergo, and may be ill-prepared to recognize and manage psychologic difficulties alre...
Article
Objective We aimed to determine the frequency and risk of malignancy (ROM) for indeterminate thyroid nodules, categories III (B3) and IV (B4) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), at a large institution in Israel. Additionally, we investigated the impact of redefining follicular neoplasm with papillary-like nuclear fea...
Article
Background: Women of reproductive age with differentiated thyroid cancer (DTC) often need to receive radioactive iodine (RAI) treatment after surgery. In contrast to the well documented effect of RAI on testicular function, the potential negative effects of this treatment on ovarian reserve have been largely dismissed. The objective of this pilot...
Article
Objective: Clinically nonfunctioning pituitary adenoma (NFPA), remain the only pituitary tumor subtype for which no effective medical therapy is available or recommended. We evaluated dopamine agonist (DA) therapy for preventing growth of post-surgical pituitary tumor remnants. Design: Historical cohort analysis of clinical results at two pituit...
Article
Full-text available
As optimal postoperative management of patients with clinically nonfunctioning pituitary adenomas (NFPA) is a matter of debate, the role of dopamine agonist (DA) therapy in this clinical setting was evaluated. Methods: Retrospective analysis of prospectively collected data was conducted at two pituitary referral centrer with different standard prac...

Citations

... One study reported that 67.4% of transgender women and 61.6% of transgender men had a desire to parent a child, with 50% and 37%, respectively, desiring a biological one. 8 Thus, fertility counseling early in the transition process can aid in attaining these goals. Health care providers should be sure to discuss all options with patients prior to hormone therapy or surgical intervention. ...
... Despite the increase in research specific to trans individuals and pregnancy in recent years, there is still limited research on trans people's reproductive health and fertility for folks who have undergone hormone replacement therapy, gender-affirming surgeries, or both. Yaish et al. (2021) explored egg reserves in trans people who have a uterus and take testosterone for a period of time, ultimately finding that testosterone had no impact on the level of anti-Mullerian hormone (a predictor of ovarian reserve) in individuals taking testosterone and not previously diagnosed with polycystic ovary syndrome. Yaish et al. (2021) note that little research exists in this area, what does exist is contradictory, and future research, especially longitudinal studies, is sorely needed. ...
... Recent data revealed that low-dose cyproterone acetate (10−20 mg/d) suppressed testosterone level to a similar level compared with highdose (50−100 mg/d). 22 The present study revealed that lowdose cyproterone acetate is used in the real world, and more data is needed to prove its efficacy in testosterone suppression. ...
... Among them, the most important is the intervention at the level of the vascular endothelium [3,4], modifying the release and production of mediators and, secondarily, the functions of the receptor systems of signal conducting systems [3,5]. Another direction of influence is the influence on the function of blood platelets responsible for the progression of the disease and its exacerbations [6][7][8], as well as the growth of atherosclerotic plaques [9,10]. Cardiovascular diseases (CVD) are responsible for over 4 million deaths annually in Europe [11]. ...
... Interestingly, however, fibromyalgia remains more prevalent in transgender men compared to transgender women. Levit et al. [31] explained that this may be attributed to the exposure of the central nervous system to female hormones during development in-utero. Sex hormones during fetal development may have lifelong effects on pain perception even if patients are receiving hormone therapy during adulthood [31]. ...
... Sofer et al (7) observed that among their otherwise similar patients, those treated with CPA had prolactin elevations whereas those treated with either spironolactone or with a GnRH agonist did not. The observation is consistent with the finding suspected by U.S. and European investigators in isolation (8,9). ...
... 14,20 It has been hypothesized that perception of physicians of an illness consists of the same dimensions as the one for patients, yet it is based on academic knowledge and clinical experience. 1 Nevertheless, qualitative studies that explore physicians' personal pain concepts are scarce, especially for the treatment of children and adolescents with chronic pain. One study reported that physicians have 3 diverging perspectives about pain, ie, biological, professional, and personal perspectives. ...
... There was a slight but statistically significant difference in sodium concentration in the subset of transgender women taking spironolactone compared to those not taking spironolactone; in contrast, potassium concentrations were not significantly different between these groups. The impact on sodium concentrations is a known consequence of spironolactone impacting the mineralocorticoid system (38), although the magnitude of changes observed may not be clinically meaningful in many cases. However, the exclusion criteria in our study (e.g., diabetes, prior severe cardiovascular event) and relatively young age of the cohort likely reduced the number of subjects with factors such as administration of angiotensin converting enzyme or angiotensin receptor antagonist medications that may also impact the Transgender Clinical Chemistry Reference Intervals ARTICLE September 2022 | 07:05 | 1131-1144 | JALM mineralocorticoid system. ...
... An aspiring TOETVA surgeon should be a high-volume thyroid surgeon proficient in procedures of the central neck 52,53 , and be familiar with either laparoscopic or endoscopic surgery. Emerging retrospective data suggest that the learning curve is somewhere between 11 and 15 procedures 38,54 , although a larger learning curve of 25-30 operations has been reported for otolaryngologist-head and neck surgeons without previous experience in robotic or laparoscopic surgery 39 . Several recommendations have been published on how aspiring TOETVA surgeons should map their professional development and involvement with this technique 52,53 . ...
... Moreover, opposite changes occur in conditions resulting from thyroid hormone deficiency (12)(13)(14). However, only few studies have investigated dyslipidemia risk in patients with TC, and these have yielded conflicting results (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), possibly because of differences in the study population, sample size, and follow-up period. ...