Inderbir S Gill's research while affiliated with Sylvester Comprehensive Cancer Center and other places

Publications (1,000)

Article
PURPOSE Patients with metastatic urothelial carcinoma have poor prognosis after failure of standard first-line chemotherapy. Immune check point programmed death 1-programmed death ligand 1 antibodies have low response rates and thus there exists a major unmet need. MATERIALS AND METHODS In this phase II trial, patients with metastatic urothelial c...
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To evaluate the relationship between pre‐operative PSA value, 68Ga‐prostate‐specific‐membrane‐antigen (PSMA) PET performance and oncologic outcomes after salvage lymph node dissection (sLND) for biochemical recurrent prostate cancer (PCa). The study included 164 patients diagnosed with ≤2 pelvic lymph‐node recurrence(s) of PCa documented on 68Ga‐PS...
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Urothelial carcinomas (UCs) are a broad and heterogeneous group of malignancies, with the prevalence of upper tract urothelial carcinoma (UTUC) being rare, accounting for only 5–10% of total malignancies. There is a need for additional toolsets to assist the current clinical paradigm of care for patients with UTUC. As a non-invasive tool for the di...
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The purpose of the study is to evaluate the impact of a multimodal Enhanced Recovery After Surgery (ERAS) protocol on perioperative opioid consumption and hospital length of stay (LOS) after robotic-assisted radical prostatectomy (RARP). We compared the first 176 patients enrolled in the protocol (ERAS group) with the previous 176 patients (non-ERA...
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INTRODUCTION AND OBJECTIVE: Obturator Nerve Injury (ONI) is a rare complication reported in 0.2% to 5.7% of pelvic surgeries. The most significant risk factor for ONI is pelvic lymph node dissection (PLND). ONI can be classified as crush and transection injuries, which have different management strategies. We present a series of robotic ONI and how...
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NTRODUCTION AND OBJECTIVE: Injury to the Superior Mesenteric Artery (SMA) during renal surgery is a rare but potentially devastating complication. It can rarely occur in patients with large left renal tumors and bulky lymphadenopathy, or in the setting of re-do surgery with significant retroperitoneal and intraabdominal scarring, which may distort...
Article
Purpose: Previously, we identified eight objective suturing performance metrics highly predictive of urinary continence recovery after robotic-assisted radical prostatectomy. Here, we aimed to test the feasibility of providing tailored feedback based upon these clinically-relevant-metrics and explore its impact on the acquisition of robotic suturi...
Article
Objectives To evaluate the utility of CT-based radiomics signatures in discriminating low-grade (grades 1–2) clear cell renal cell carcinomas (ccRCC) from high-grade (grades 3–4) and low TNM stage (stages I–II) ccRCC from high TNM stage (stages III–IV).MethodsA total of 587 subjects (mean age 60.2 years ± 12.2; range 22–88.7 years) with ccRCC were...
Article
Introduction: Augmented reality (AR) applied to surgical procedures refers to the superimposition of preoperative or intra-operative images onto the operative field. Augmented reality has been increasingly used in myriad surgical specialties including Urology. The following study reviews advances in the use of AR for improvements in urologic outco...
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Importance: The US Preventive Services Task Force (USPSTF) has recommended against routine prostate-specific antigen (PSA)-based prostate cancer (PCa) screening, initially for men older than 75 years in 2008, and then for all men in 2012. Concern has been raised that, by recommending against screening, and thus early detection, the USPSTF recommen...
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Enhanced Recovery After Surgery (ERAS) protocols have been developed in several fields to reduce hospitalization lengths and overall costs. There have also been developments in multimodal analgesia methods to curtail opioid usage after surgery. Herein, we present the results of our initiation of an ERAS protocol for robotic-assisted laparoscopic pa...
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Urinary bladder cancer (BCa) is the 10th most frequent cancer in the world, most commonly found among the elderly population, and becomes highly lethal once cells have spread from the primary tumor to surrounding tissues and distant organs. Cystectomy, alone or with other treatments, is used to treat most BCa patients, as it offers the best chance...
Preprint
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Tissue regeneration is limited in several organs including the kidney, contributing to the high prevalence of kidney disease globally. However, evolutionary and physiological adaptive responses and the presence of renal progenitor cells suggest existing remodeling capacity. This study uncovered a novel endogenous tissue remodeling mechanism in the...
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Background Bladder cancer (BCa), the sixth commonest cancer in the USA, is highly lethal when metastatic. Spatial and temporal patterns of patient-specific metastatic spread are deemed random and unpredictable. Whether BCa metastatic patterns can be quantified and predicted more accurately is unknown. Objective To develop a web-based calculator fo...
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Objectives To evaluate the impact of 5-alpha reductase inhibitors (5-ARIs) on definitive treatment (DT) and pathological progression (PP) in patients on active surveillance (AS) for prostate cancer.Methods We identified 361 consecutive patients, from an IRB-approved database, on AS for prostate cancer with minimum 2 years follow-up. Patients were g...
Article
Background: A substantial proportion of patients undergo treatment for renal masses where active surveillance or observation may be more appropriate. Objective: To determine whether radiomic-based machine learning platforms can distinguish benign from malignant renal masses. Design, setting, and participants: A prospectively maintained single-...
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INTRODUCTION AND OBJECTIVE: Robotic-assisted radical cystectomy with intracorporeal urinary diversion (RARC-ICUD) is now widely considered a standard of care treatment for muscle invasive bladder cancer with equivalent oncologic and functional outcomes compared to traditional open radical cystectomy with extracorporeal urinary diversion. RARC and...
Article
Recent advancements in imaging technology and biopsy strategies have improved tumor localization and risk stratification for prostate cancer (PCa).¹ Concurrently, growing evidence supports the indolent nature of most PCa cases.² These developments have created the impetus for clinicians to explore more tailored treatment approaches for patients dia...
Article
Background: The optimal definition and prognostic significance of persistently elevated prostate-specific antigen (PSA) after salvage lymph node dissection (sLND) for node-only recurrent prostate cancer (PCa) remain unknown. Objective: To assess the definition and clinical implications of persistently elevated PSA after sLND for node-only recurr...
Article
Purpose: To evaluate the prostate cancer (PCa) and clinically significant PCa (CSPCa) detection on systematic (SB), target biopsy (TB) alone and combined SB and TB in men with Prostate Imaging Reporting and Data System (PIRADS)-5 lesion. Material and methods: From a prospectively maintained prostate biopsy (PBx) database, we identified consecuti...
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Purpose of Review The goal of this study is to review recent findings and evaluate the utility of MRI transrectal ultrasound fusion biopsy (FBx) techniques and discuss future directions. Recent Findings FBx detects significantly higher rates of clinically significant prostate cancer (csPCa) than ultrasound-guided systematic prostate biopsy (SBx),...
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Purpose: To determine web-based public interest in minimally invasive surgery (MIS) specifically for urological oncological surgical procedures and how interest in robotics and laparoscopy compares over time. Materials and methods: Worldwide search-engine trend analysis included electronic Google queries of MIS urologic options from January 2004 t...
Article
Background: With the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS). Methods: A 3-sta...
Article
The field of artificial intelligence continues to advance rapidly. Improvements in both patient outcomes and the patient-doctor relationship may occur if physicians embrace this technology.
Article
Objectives Using a radiomics framework to quantitatively analyze tumor shape and texture features in three dimensions, we tested its ability to objectively and robustly distinguish between benign and malignant renal masses. We assessed the relative contributions of shape and texture metrics separately and together in the prediction model.Materials...
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Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and limitations in earlier microscopy techniques. The present study used a new mouse model with a comprehensive imaging approach to visualize so far unexplored...
Article
Background Salvage radical prostatectomy (sRP) historically yields poor functional outcomes and high complication rates. However, recent reports on robotic sRP show improved results. Our objectives were to evaluate sRP oncological outcomes and predictors of positive margins and biochemical recurrence (BCR). Methods We retrospectively collected dat...
Article
Minimally invasive renal surgery has revolutionized the surgical management of renal cancer since the initial report of laparoscopic nephrectomy in 1991. Laparoscopic nephrectomy became the mainstay of management in surgically resectable renal masses since the 1990s. The growing body of literature supporting nephron-sparing surgery over the last tw...
Article
Background Use of partial nephrectomy (PN) in T3 renal cell carcinoma (RCC) is controversial. Objective To evaluate quality outcomes of robot-assisted PN (RAPN) for clinical T3a renal masses (cT3aRM). Design, setting, and participants This was a retrospective multicenter analysis of patients with cT3aN0M0 RCC who underwent RAPN. Intervention RAP...
Article
Objective: To investigate the utility of multiparametric magnetic resonance imaging (mpMRI) in the reassessment and monitoring of patients on active surveillance (AS) for Grade Group (GG) 1 prostate cancer (PCa). Patients and methods: We identified, from our prospectively maintained IRB-approved database, 181 consecutive men enrolled on AS for G...
Article
Objective: To examine the timing, patterns and predictors of 90-day readmission after robotic radical cystectomy. Methods: From September 2009 to March 2017, 271 consecutive patients undergoing robotic radical cystectomy (RRC) with intent to cure bladder cancer (intracorporeal diversion N=253, 93%) were identified from our prospectively collated...
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Purpose: We report outcomes of hemigland high intensity focused ultrasound ablation as primary treatment for localized prostate cancer in the United States. Materials and methods: A total of 100 consecutive men underwent hemigland high intensity focused ultrasound (December 2015 to December 2019). Primary end point was treatment failure, defined...
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The best surgical template for salvage pelvic lymph node dissection (sLND) in patients with nodal recurrence from prostate cancer (PCa) after radical prostatectomy (RP) is currently unknown. We analyzed data of 189 patients with a unilateral positive positron emission tomography (PET) scan of the pelvic lymph node areas, who were treated with bilat...
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Purpose In this study, we investigate the ability of automated performance metrics (APMs) and task-evoked pupillary response (TEPR), as objective measures of surgeon performance, to distinguish varying levels of surgeon expertise during generic robotic surgical tasks. Additionally, we evaluate the association between APMs and TEPR. Methods Partici...
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The EAU guidelines panel on muscle-invasive and metastatic bladder cancer (MIBC) recently recommended open radical cystectomy (ORC) as the best surgical approach for MIBC patients. We critically re-examine the indications for considering ORC as the first choice over robot-assisted radical cystectomy. To the best of our knowledge, this is not suppor...
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Background Long-term outcomes of patients treated with salvage lymph node dissection (sLND) for nodal recurrence of prostate cancer (PCa) remain unknown. Objective To investigate long-term oncological outcomes after sLND in a large multi-institutional series. Design, setting, and participants The study included 189 patients who experienced prosta...
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Purpose: Population-based data on survival after radical cystectomy (RC) are lacking from Southern Europe. The aim of this study was to assess trends and determinants of perioperative mortality and long-term survival in the Veneto region (Northeastern Italy). Methods: All patients submitted to RC for bladder cancer from January 2004 to December...
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Purpose: To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. Patients and methods: We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from our institutional review bo...
Article
Objective To compare outcomes of minimally invasive radical nephrectomy (MIS‐RN) and robotic‐assisted partial nephrectomy (RAPN) in clinical T2a renal mass (T2aRM). Methods Retrospective, multicenter, propensity score‐matched (PSM) comparison of RAPN and MIS‐RN for T2aRM (T2aN0M0). Cohorts were PSM for age, sex, BMI, ASA Class, clinical tumor size...
Article
Introduction: The aim of the study was to compare 11C-Choline and 68Ga-PSMA in men undergoing SLND for nodal recurrent PCa. Materials and methods: The study included 641 patients who experienced PSA rise and nodal recurrence after radical prostatectomy and underwent SLND. Lymph node recurrence was documented by PET/CT scan using either 11C-Choli...
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Introduction Minimally invasive surgery in urology has grown considerably in application since its initial description in the early 1990s. Herein, we present the protocol for a systematic review and meta-analysis comparing open versus robotic urological oncological surgery for various clinically relevant outcomes, as well as to assess their compara...
Article
We performed a systematic review and meta-analysis on the response rates of patients with treatment-refractory urothelial carcinoma treated with programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors. We reviewed the literature for prospective studies evaluating PD-1/PD-L1 inhibitors in refractory urothelial carcinoma patie...
Article
Considering how easy it is to access the Internet, it is natural to wonder whether people use this tool and which information they look for. Web searches might have an advantageous and/or harmful impact on patient-doctor decision-making. Google Trends (GT) is a free, easily accessible tool that enables analysis of worldwide "big data" on the relati...
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Background: Several studies have investigated the relationship between experience measured by caseload and oncological outcomes, economics, and access to care for prostate cancer care. Oncological outcomes have been limited to biochemical failure after radical prostatectomy. Questions remain regarding the more definitive measures of outcomes and t...
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Purpose: To evaluate 5-year oncologic and functional outcomes of hemi-gland cryoablation (Hemi-Cryo) for localized prostate cancer (PCa). Materials and methods: We reviewed the records of 160 consecutive men who underwent Hemi-Cryo for localized PCa. Recurrent/residual clinically significant PCa (CSPCa) was defined as Grade Group (GG) ≥ 2 on fol...
Conference Paper
Background EphB4 is upregulated in prostate cancer in over half the cases, and correlates with stage and survival. EprhinB2, the ligand for EphB4 has not been well studied. Functional studies show EphB4 provides a survival signal through the PI3K/PTEN/Akt/pS6 pathway. A therapeutic agent, soluble EphB4-albumin fusion protein (sEphB4) which blocks b...
Article
The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and consequent overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mpMRI) of the prostate has been identified as a test that could mitigate these diagnostic errors. The performance of mpMRI can vary depending on the population...