In-Young Yoon's research while affiliated with Seoul National University Bundang Hospital and other places

Publications (126)

Article
Insomnia is a commonly occurring sleep problem in shift workers. So far, no studies have investigated how insomnia symptoms present differently in shift workers and non-shift workers. The purpose of this study was to compare the network structures and centrality indices of shift and non-shift workers using network analysis and network comparison te...
Article
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Background Many people in modern society have insufficient exposure to ultraviolet B (UVB) sunlight, which may lead to vitamin D deficiency. We aimed to investigate the effect of a proto-type wearable light-emitting diode (LED) device emitting UVB light on serum 25-hydroxyvitamin D levels. Methods A total of 136 healthy adults were randomly assign...
Article
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This study aimed to compare the effects of Autonomous sensory meridian response (ASMR) and binaural beat (BB) on stress reduction, and to determine whether ASMR and BB can induce changes in quantitative electroencephalography (QEEG). A double-blind randomized trial was conducted. Subjects with stress were recruited considering their perceived stres...
Preprint
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A 2-week, randomized, double blind, and controlled study was designed to evaluate the therapeutic effectiveness and safety of a neurofeedback wearable device for stress reduction. Participants were healthy adults with psychological stress and subclinical symptoms of depression or anxiety. Subjects practiced either neurofeedback-assisted meditation...
Article
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Vitamin D deficiency is prevalent in many developed countries, and several studies suggest that vitamin D plays an essential role in brain function. A recent study showed that vitamin D deficiency was closely associated with daytime sleepiness and shorter sleep time. The relationshipbetween vitamin D levels and calcium levels is well established, a...
Preprint
Full-text available
This study aimed to compare the effects of Autonomous sensory meridian response (ASMR) and binaural beat (BB) on stress reduction, and to determine whether ASMR and BB can induce changes in quantitative electroencephalography (QEEG). A double-blind randomized trial was conducted. Subjects with stress were recruited considering their perceived stres...
Article
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Objective Insomnia disorder is a common condition with considerable harmful effects on health. We investigated the therapeutic effi- cacy and safety of low-frequency transcutaneous electric nerve stimulation (LF-TENS) as an alternative treatment option for insomnia disorder. Methods A 4-week, multi-center, randomized controlled study was conducted....
Article
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Purpose: Nocturnal sounds contain numerous information and are easily obtainable by a non-contact manner. Sleep staging using nocturnal sounds recorded from common mobile devices may allow daily at-home sleep tracking. The objective of this study is to introduce an end-to-end (sound-to-sleep stages) deep learning model for sound-based sleep stagin...
Article
Introduction Convenient sleep tracking with mobile devices such as smartphones is desirable for people who want to easily objectify their sleep. The objective of this study was to introduce a deep learning model for sound-based sleep staging using audio data recorded with smartphones during sleep. Methods Two different audio datasets were used. On...
Article
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Objective This study was performed to investigate altered regional gray matter volume (rGMV) and structural covariance related to somatic symptom disorder (SSD) and longitudinal changes after treatment. Additionally, this study examined the relationships of structural alteration with its phenotypic subtypes. Methods Forty-three unmedicated patient...
Article
Objective: The relationship between benzodiazepine use and cognitive decline in insomnia patients has been reported, but still conflicting. Thus, we tried to determine whether long-term exposure of benzodiazepine might be associated with changes of cognition and electroencephalography (EEG) findings in patients with chronic insomnia. Methods: In...
Article
Study objectives: Patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) are known to be at risk of neurodegenerative diseases but the time process of neurodegeneration remains unclear and its ethnic difference is rarely discussed. The objective of this study was to investigate clinical manifestation of iRBD according to di...
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Binaural beat (BB) stimulation, which has two different frequencies for each ear, is reportedly effective in reducing anxiety and controlling mood. This study aimed to evaluate the brain wave entrainment effect of binaural beats and to propose an effective and safe supplementary therapy for relieving the symptoms of insomnia. Subjects between 20 an...
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Study objectives: Automated sleep stage scoring is not yet vigorously used in practice because of the black-box nature and the risk of wrong predictions. The objective of this study was to introduce a confidence-based framework to detect the possibly wrong predictions that would inform clinicians about which epochs would require a manual review an...
Article
Objective This study aimed to evaluate the clinical correlates of sleep discrepancy and how subjective-objective sleep discrepancy (SD) affects the results of cognitive behavioral therapy for insomnia (CBTI) in patients with insomnia disorder. Methods A total of 33 patients aged >55 years with insomnia disorders participated in this prospective co...
Article
Objective The quantitative electroencephalography (qEEG) of patients with somatic symptom disorder (SSD) was not yet thoroughly studied. This study aimed to investigate qEEG of SSD patients compared with those of normal controls (NCs), and changes therein after treatment. Methods SSD patients currently without treatment and age- and sex-matched NC...
Article
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The human gut microbiome is closely linked to mental health and sleep. We aimed to verify the efficacy and safety of probiotic NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98, in improving stress, depression, anxiety, and sleep disturbances, along with the measurement of some blood biomarkers. A total of 156...
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Background and Objective Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at the risk of developing neurodegenerative disorders including mild cognitive impairment (MCI). MCI is prevalent among iRBD patients and is the predictive factor for future dementia. We hypothesized that objective cognitive impairment (OCI) migh...
Article
Study objectives: Sleep characteristics are known to be different according to age and sex. The objective of this study was to investigate differences in sleep parameters and quantitative electroencephalogram (qEEG) of patients with insomnia according to age and sex. Methods: Patients with insomnia disorder ages 40-79 years were recruited. Each...
Preprint
Full-text available
This study was performed to investigate altered regional gray matter volume (rGMV) and structural covariance related to somatic symptom disorder (SSD) and its phenotypic subtypes. Additionally, this study examined the relationships of structural alteration with cognitive functioning and clinical symptoms. Forty-three unmedicated patients with SSD a...
Preprint
Full-text available
A 4-week, multi-center, randomized controlled study was conducted to evaluate the therapeutic efficacy and safety of low-frequency transcutaneous electric nerve stimulation (LF-TENS) for insomnia disorder. A total of 160 individuals aged 40 to 80 years with insomnia disorder were included and randomized to the experimental group receiving active de...
Article
Full-text available
Objective: Among veterans, the prevalence of rapid eye movement sleep behavior disorder (RBD) is higher than among the general population, and some evidence suggests that this is related to post-traumatic stress disorder (PTSD). The purpose of this study was to determine whether the frequency of RBD differs depending on the presence of PTSD or tra...
Article
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Conventionally, apnea–hypopnea index (AHI) is used to define and categorize the severity of obstructive sleep apnea. However, routine polysomnography (PSG) includes multiple parameters for assessing the severity of obstructive sleep apnea. The goal of this study is to identify and categorize obstructive sleep apnea phenotypes using unsupervised lea...
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Parkinson's disease (PD) is a multisystemic disorder characterized by various non-motor symptoms (NMS) in addition to motor dysfunction. NMS include sleep, ocular, olfactory, throat, cardiovascular, gastrointestinal, genitourinary, or musculoskeletal disorders. A range of NMS, particularly hyposmia, sleep disturbances, constipation, and depression,...
Article
Introduction In veterans, the prevalence of rapid eye movement (REM) sleep behavior disorder(RBD) is higher than the general population, and there is some evidence that this is related to posttraumatic stress disorder(PTSD). In addition, trauma related nightmares (TRNs) interfere with REM sleep and are often accompanied by motor activity. (rem slee...
Article
Introduction It has been reported that binaural beat stimulation, which has two different frequencies on both ears, is effective in increasing alertness, memory, reducing anxiety, and controlling mood. This study aims to clarify the brain wave entrainment effect of binaural beat and to identify the mechanism of action of the binaural beat. Methods...
Article
Previous studies have shown the therapeutic effects of clonazepam for rapid eye movement sleep behavior disorder (RBD), but they had several limitations such as the lack of clear definition of treatment outcomes and little information about adjuvant therapy. The aims of this study were to evaluate the treatment outcomes with clonazepam and to explo...
Article
Study objectives: Low serum vitamin D levels are known to be associated with working conditions and poor sleep, but precedent studies on this issue were limited by the absence of objective sleep measurements or clear distinction between daytime and night shift work. Hence, we aimed to examine serum vitamin D levels and sleep in daytime and night-s...
Article
Study design: This was a cross-sectional cohort study. Objective: The objective of this study was to identify the prevalence of sleep disturbance in patients with symptomatic lumbar spinal stenosis (LSS) and to establish the relationship between sleep disturbance and both functional disability and health-related quality of life in patients with...
Article
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Purpose Obstructive sleep apnea (OSA) is highly prevalent and causes serious cardiovascular complications. Several screening questionnaires for OSA have been introduced, but only few validation studies have been conducted in general population. The aim of the present study was to assess the diagnostic value of three OSA screening questionnaires (Be...
Article
Background: Auditory binaural beat (BB) stimulation is known to modulate electroencephalographic activity by brain entrainment, but few studies have established whether BB can affect the sleep state. We examined the effect of θ BB in improving sleep disturbances and daytime alertness. Methods: We conducted double-blind and sham-controlled random...
Article
Introduction Rapid eye movement sleep behavior disorder (RBD) is characterized by unpleasant dreams and dream-enacting behaviors that can result in sleep-related injuries. For treatment of RBD, clonazepam has been widely used. The aims of this study were (1) to evaluate the treatment outcome with clonazepam and (2) to explore associated factors rel...
Article
Autosomal dominant spinocerebellar ataxia type 17 (SCA17) is known to have various manifestations. Previously, ataxia and autonomic dysfunction have been reported with this disorder, making an overlap with multiple systemic atrophy (MSA). However, respiratory complications, especially stridor during sleep, have not yet been reported with SCA17, in...
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Objective The present study compared cancer-related fatigue (CRF) and chronic fatigue syndrome (CFS) using multidimensional measurements with the aim of better understanding characteristics and exploring markers of two similar fatigue syndromes. Methods Twenty-five patients with CRF and twenty patients with CFS completed questionnaires, including...
Article
Objective:: In elderly patients, women have better qualities of sleep than men in objective parameters; however, women subjectively complain more about sleep disturbances than men. We performed visual scoring and spectral analysis of sleep electroencephalograms to explain these gender differences in the degree of arousal, the most representative m...
Article
Previous studies have revealed the negative consequences of shift work in some individuals, with others better tolerating shift work. The present study investigated clinical implications of shift work-related sleep complaints as a manifestation of shift-work intolerance. Responses were obtained from 923 shift workers and 850 non-shift workers at Se...
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Background and Objective Little is known about the factors associated with disruptive behaviors in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). Thus, we report the demographic and clinical characteristics of iRBD patients with disruptive behaviors. Methods Patients diagnosed as having iRBD through video-polysomnography were i...
Article
Introduction Few studies have investigated the validity of obstructive sleep apnea (OSA) screening questionnaires in general population. The aim of the present study was to assess the diagnostic value of three OSA screening questionnaires (the Berlin Questionnaire, BQ; the STOP-Bang Questionnaire, STOP-B; the Four-Variable Screening Tool, Four-V) i...
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Objective: The aim of this study was to determine the clinical course of restless legs syndrome (RLS) and potential risk factors for the persistence of RLS symptoms after iron normalization in women with RLS and low serum ferritin (<50 μg/L). Methods: We reviewed 39 women with RLS and iron deficiency, who achieved iron normalization after oral i...
Article
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients...
Article
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Objective It has been reported that untreated sleep-disordered breathing (SDB) deteriorates over time, however this remains contentious. The aim of the present study is to evaluate the clinical course of SDB in middle-aged and older SDB patients, and to identify how relevant factors contribute to the change in SDB severity. Methods Baseline and fo...
Article
Introduction Although transcutaneous electrical nerve stimulation (TENS) was known as relieving neuromuscular pain, it has been rarely used to treat insomnia. The aim of this study was to investigate additional effects of low-frequency electrical stimulation on chronic insomnia. Methods Fifty-four patients with chronic insomnia who took medication...
Article
Introduction Effects of circadian typology (CT) on various psychological and physiological conditions have been controversial. We aimed to investigate the association between CT and sleep, mood, and quality of life (QOL) after controlling for possible confounding factors, and to assess how the effect of CT differs depending on the variables in empl...
Article
Various physiological and psychological functions are influenced by circadian typology (CT), which was reported to be related to resilience. However, few studies have assessed the effects of CT in relation to resilience. The aim of the present study was to assess the influence of CT on sleep-related symptoms, physical fatigue and psychological well...
Data
Dataset of key variables of the study subjects. (DOCX)
Article
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Background Sleep disordered breathing (SDB) and sleep disturbances have been reported to be associated with allergic rhinitis and asthma. However, population-based studies of this issue in the elderly are rare. Objective To investigate the impact of self-reported rhinitis and asthma on sleep apnea and sleep quality using polysomnography in an elde...
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Background and Objective Restless legs syndrome (RLS) lowers the quality of sleep, and is characterized by symptoms that follow a circadian pattern. The aim of this study was to determine the relationship between RLS and morning-eveningness in Korean adolescents. Methods Of the 867 community-dwelling high school students, 590 subjects were included...
Article
The aim of this study was to find electroencephalographic (EEG) changes in subjects with drug-naïve idiopathic rapid eye movement sleep behavior disorder (iRBD) who had no cognitive impairment. A total of 57 iRBD patients confirmed by polysomnography (PSG) and 33 sex and age-matched healthy controls were included and their waking EEG was recorded f...
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Background and Objective Obstructive sleep apnea (OSA) in elderly is accompanied by cognitive decline. However, it is not well known whether these deleterious changes can be reversed by continuous positive airway pressure (CPAP) treatment. Therefore, we aimed to elucidate the effect of CPAP on cognitive function in the Korean elderly with OSA. Meth...
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Objectives: The acute cessation of smoking often induces symptoms that are similar to those associated with delirium. We aimed to evaluate effects of sudden nicotine abstinence on the development of delirium and its motoric subtypes in hospitalized patients. Methods: The present study included patients who were referred to psychiatrists by ward...
Article
Objective: This study examines the clinical course of restless legs syndrome (RLS) according to its severity, and factors associated with the remission of RLS symptoms. Methods: The remission or persistence of RLS symptoms were investigated by considering RLS patients at the sleep clinic of Seoul National University Bundang Hospital. All subject...
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Objectives: The association between sleep disturbances and cognitive decline in the elderly has been putative and controversial. We evaluated the relation between subjective sleep quality and cognitive function in the Korean elderly. Method: Among 459 community-dwelling subjects, 352 subjects without depression or neurologic disorders (mean age...
Article
Objectives: This study aimed to investigate the dynamic upper airway changes occurring in an obstructive sleep apnea (OSA) rabbit model using dynamic computerized tomography (CT). Methods: In this study, 2.5 U of botulinum toxin type A was injected into the genioglossus to paralyze the tongue in the OSA group (n = 7). The control group was injec...
Article
Background: Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of cognitive dysfunction in iRBD. Methods: A retrospective follow-up study with patients with iRBD was performed. Conversion to neurodegenerative disorders was analysed by Ka...
Article
Previous studies have shown a relationship between obstructive sleep apnea (OSA) and erythrocyte sedimentation rate (ESR), a representative marker for inflammation. We aimed to elucidate the possible association between elevated ESR and OSA severity. A total of 341 patients who visited a sleep center were retrospectively enrolled. Subjects underwen...
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The definition and the criteria for the successful treatment of obstructive sleep apnea vary, depending on the study. This study aimed to compare different success criteria of non-continuous positive airway pressure (non-CPAP) treatment for obstructive sleep apnea in terms of sleep quality by using cardiopulmonary coupling. We included 98 patients...
Article
Although the impact of obstructive sleep apnea (OSA) on cardiovascular risk is reasonably well established in middle-aged patients, the debate persists as to whether OSA also increases this risk in the elderly. Arterial stiffness has been used as an early independent predictor of cardiovascular risk. We sought to determine whether OSA has significa...
Poster
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Background: Dopamine agonists are first-line treatments for restless legs syndrome (RLS), and their long-term use is known to be related to occurrence of augmentation and tolerance. This study aimed to estimate the prevalence of augmentation and tolerance and figure out their characteristics and risk factors in patients taking RLS medications for l...
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Background and Objective Excessive daytime sleepiness (EDS) is commonly reported by the elderly, but has not been well-described in older adults in Korea. This study aimed to estimate the prevalence and risk factors of EDS, and investigated the relationship between EDS and cognitive impairment in an older Korean population. Methods The cross-sectio...
Article
Objectives: Depression, sleep complaints and cognitive impairments are commonly observed in the elderly. Elderly subjects with depressive symptoms have been found to show both poor cognitive performances and sleep disturbances. However, the relationship between sleep complaints and cognitive dysfunction in elderly depression is not clear. The aim o...
Article
Purpose The aim of this study is to evaluate the changes of sleep quality in patients using a mandibular advancement device (MAD) for obstructive sleep apnea (OSA) based upon cardiopulmonary coupling (CPC). Methods A total of 52 patients (mean age 53.7 ± 9.6 years, range 33–74 years) were included in this study. Of them, there were 47 males (90....
Article
Background: There are just a few epidemiological studies on sleep-disordered breathing (SDB) in the elderly, and the results are inconsistent. Study objectives: We sought to investigate the prevalence of and risk factors for SDB in a representative elderly population with the use of attended nocturnal polysomnography (NPSG). Methods: Among 6,9...
Article
Studies on the association between gastroesophageal reflux disease (GERD) and sleep apnea syndrome (SAS) have reported conflicting results, and attention has not been paid to the relationship between GERD and other sleep disorders. The aim of the study was to evaluate the relationship between GERD and various aspects of sleep disturbances. A total...
Article
The purposes of this study were to evaluate clinical outcome of mandibular advancement device (MAD) for obstructive sleep apnea (OSA) patients and to estimate influencing factors on MAD effect. From the patients who were diagnosed as OSA by polysomnography at Seoul National University Bundang Hospital from January 2007 to February 2009, the patient...
Article
Weak cardiorespiratory coupling (CRC) has been suggested in patients with obstructive sleep apnea (OSA), but the effects of continuous positive airway pressure (CPAP) on CRC remain unclear. We investigated the effects of CPAP treatment on CRC in patients with severe OSA to examine possible reversibility of altered CRC. High-resolution electrocardio...
Article
Importance This study presents an innovative method for developing a neuromuscular model of obstructive sleep apnea (OSA). Objective To establish a new OSA animal model simulating real upper airway conditions during sleep.Design and Setting In vivo animal study at an academic tertiary referral center.Subjects A total of 27 New Zealand white mal...
Article
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To examine the prevalence and clinical characteristics of REM sleep behavior disorder (RBD) and subclinical RBD in the Korean elderly population. A community-based Korean Longitudinal Study on Cognitive Aging and Dementia and time-synchronized video-polysomnography (vPSG) in a laboratory. Sleep laboratory in a university hospital. 348 individuals a...
Article
Objectives: Cognitive impairment in restless legs syndrome (RLS) patients can be affected by sleep deprivation, anxiety and depression, which are common in RLS. The objective of this study is to investigate relationship between cognitive impairment and RLS in the non-medicated Korean elderly with controlling for psychiatric conditions. Method: The...
Article
Background: Recent data suggest that obstructive sleep apnea (OSA) is an important contributor to severe uncontrolled asthma. Objective: To investigate the clinical characteristics, asthma control, and asthma-related quality of life in adult patients with asthma at a high risk for OSA. Methods: A total of 217 patients with asthma who visited o...
Article
BACKGROUND: Suicide prevention in the elderly is a major public health priority worldwide and in Korea in particular. We investigated the one-month-point prevalence and factors related to suicidality for suicidal behaviors in elderly Koreans. METHODS: A simple random sample (N=1588) was drawn from the residential roster of 14,051 Koreans aged 60 ye...
Article
Although mandibular advancement device (MAD) is widely used, there are a few papers comparing the efficacy and compliance at the same time according to the type of MAD. The aim of this study is to compare the efficacy and compliance between mono-bloc and bi-bloc MAD in the treatment of obstructive sleep apnea (OSA). Ninety-three patients who treate...
Article
The objective of this study was to assess treatment outcomes and compliance according to obesity among groups of patients with obstructive sleep apnea (OSA) receiving different treatments. A total of 297 patients with OSA treated between 2006 and 2009 underwent pre- and post-treatment polysomnography. One hundred and fifty-one patients were treated...
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A total of 85 sleep disorders are described in the International Classification of Sleep Disorders, 2nd ed. Knowledge about those sleep disorders will be essential not only for good and healthy sleep but also for maintaining adequate physical and mental function during daytime. Sleep medicine has a relatively short history compared to other medical...
Article
Study Type – Symptom prevalence (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Sleep apnoea syndrome (SAS) can be a risk factor for nocturia, although whether the relationship between nocturia and SAS changes according to age remains to be addressed. SAS has a modest impact on nocturia frequency and the prev...
Article
This study was done to investigate change of electroencephalography (EEG) slowing and its relationship to daytime sleepiness and cognitive functions by continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea syndrome (OSAS). We enrolled thirteen male subjects with severe OSAS, and all the subjects were treated with CPAP...
Article
Evidence from previous studies suggests autonomic dysregulation in patients with major depressive disorder (MDD). Antidepressant treatment may also affect central autonomic function. We investigated whether the type of antidepressant might be associated with the pattern of cardiorespiratory coordination in non-depressed women with recurrent MDD. Re...
Article
Background: Decreased cerebral glucose metabolism has been reported in patients with sleep apnea syndrome (SAS), but it has yet to be decided whether cerebral glucose metabolism in SAS can be altered by continuous positive airway pressure (CPAP) treatment. Objective: The aim of this study was to evaluate cerebral glucose metabolism changes in pa...