Imel Ramelia Hudaya’s research while affiliated with University of Singaperbangsa Karawang and other places

Silver nanoparticles (AgNPs) are renowned for their potent antimicrobial potential against a diverse range of microorganisms, including bacteria. The robustness of this reaction can be attributed to the particles’ limited dimensions and expansive surface region. The term “green synthesis” in the context of nanomaterials refers to the creation of nanoparticles from varied metals using bioactive compounds, including plant substances. In this current investigation, the ethanolic leaf extract of Toona sureni (TSELE) has been employed for the inaugural application in the synthesis of silver nanoparticles. It functions as a reducing, stabilizing and capping agent. A primary focus of this study was to assess the antibacterial capabilities of these biosynthesized silver nanoparticles (referred to as TSELE-AgNPs) against a selection of microorganisms, namely Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Methicillin-Resistant Staphylococcus aureus (MRSA). Analytical instruments including the UV-VIS spectrophotometer, Fourier Transform Infrared Spectroscopy (FTIR), Particle Size Analyzer (PSA), Field Emission Scanning Electron Microscopy (FESEM-EDX), Transmission Electron Microscopy (TEM), and X-Ray Diffraction (XRD) were enlisted to perform a comprehensive analysis of the AgNPs. The antibacterial potency of the synthesized AgNPs was subsequently determined. The peak absorbance of the AgNPs was registered at a wavelength of 460 nm. An average size of 64.2 nm was recorded for the AgNPs, and a Polydispersity Index (PI) score of 0.357 was obtained, suggesting the particles were largely monodisperse. XRD data revealed that TSELE-AgNPs exhibited a face-centered cubic structure, with the mean crystallite size corresponding to a measurement of 5.01 nm. Demonstrating potent antibacterial activity, the AgNPs depicted Minimum Inhibitory Concentration (MIC) values spanning from 62.5 to 250 µg/ml against the selected clinical isolates. The study effectively illustrates the streamlined synthesis of AgNPs using TSELE in the capacity of a bioreductor, stabilizer, and capping agent in an alternative green synthesis method. Moreover, the research sheds light on the exhibited antibacterial efficacy by the synthesized AgNPs.

Setiap tahun, diperkirakan sebanyak 20% populasi dunia mengalami nyeri. Berdasarkan penelitian pada tahun 2012 di Amerika, setiap harinya terdapat sebanyak 86,6 juta jiwa orang dewasa yang mengalami nyeri akut dan sebanyak 25,5 juta jiwa mengalami nyeri kronis. Terapi menggunakan obat-obatan adalah salah satu upaya yang dapat mengurangi atau mengatasi nyeri. Obat anti inflamasi non-steroid (OAINS) merupakan salah satu obat yang paling sering digunakan dalam tatalaksana nyeri. Penggunaan OAINS yang kurang tepat akan menimbulkan banyak efek samping yang dapat berpotensi berakibat fatal dan justru dapat membuat seseorang mengalami masalah medis akibat efek samping yang lebih berat dibandingkan dengan masalah medis utamanya. Penulisan artikel review ini dimaksudkan untuk melihat pengaruh tingkat pengetahuan masyarakat dalam penggunaan OAINS terhadap rasionalitas penggunaannya secara swamedikasi di beberapa populasi masyarakat dengan metode studi literatur yang diambil dari berbagai jurnal nasional maupun internasional. Berdasarkan hasil studi literatur tersebut didapatkan hasil bahwa tingkat pengetahuan masyarakat dalam penggunaan OAINS secara swamedikasi memiliki hubungan dengan rasionalitas penggunaannya. Kata Kunci: OAINS, Tatalaksana Nyeri, Pengetahuan, Efek Samping, Swamedikasi It is estimated that 20% of the world's population experience pain every year. Based on American research in 2012, there are 86.6 million adults who experience acute pain every day and as many as 25.5 million people experience chronic pain. Drugs therapy is one of the efforts that can reduce or overcome pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs in pain management. Inappropriate use of NSAIDs will cause many side effects that can be potentially fatal and can actually make a person experience medical problems due to side effects that are more severe than the main medical problem. This review article was written to see the effect of the level of public knowledge in the use of NSAIDs on the rationality of their use by self-medication in several population groups using the literature study method taken from various national and international journals. Based on the results of the literature study, it was found that the level of public knowledge in the use of NSAIDs independently has a relationship with the rationality of their use.