Ika Agus Rini's research while affiliated with Universitas Padjadjaran and other places

Publications (4)

Article
Full-text available
Purpose: N-acetyltransferase-2 enzyme in the liver, encoded by NAT2 gene, plays a central role in metabolizing tuberculosis (TB) drug isoniazid (INH). Low compliance of patients toward six-month TB therapy and internal host factors, ie comorbid diseases, immune status, and genetic profiles, are factors leading to treatment failure and recurrence o...
Article
Full-text available
BACKGROUND: Systemic lupus erythematosus (SLE) patients living in Indonesia are prone to tuberculosis (TB) infection, since this country ranks second globally for TB prevalence. Isoniazid, an anti-tuberculosis (TB) drug, is metabolized by enzyme N-acetyltransferase 2 (NAT2) that is encoded by NAT2 gene. NAT2 haplotype, referring as acetylator statu...
Article
Full-text available
BACKGROUND: From all of human papillomaviruses (HPV) genotypes capable of causing cervical cancer, it is estimated that 70 percent are HPV-16 and HPV-18. HPV-16 can infect the tissues in single infection or together with other high-risk types of HPV, and the most common is with HPV-18. The origin of HPV can be identified by its phylogenetic tree. T...
Article
Full-text available
BACKGROUND: Chronic infection with high-risk type of human papillomavirus (HPV) can cause cervical cancer. Previous studies showed that multiple infections of HPV are found in cervical cancer caused by multiple HPV infections and the most common are HPV-16 and HPV-52. The origin of HPV-16 circulating in Indonesia varies. The purpose of this study w...

Citations

... Our findings on the frequency of fast acetylator phenotype in the studied population agrees with the report of Sahiratmadja et al., (2021), even though their classification incorporated the intermediate acetylator phenotype. The highest percentage of fast acetylators in our study were observed in subjects with blood group O+ve followed by blood group A+ve. ...
... LTBI treatment requires a long period of therapy, for example, Isoniazid (INH) needs to be given for 6 or 9 months [4]. Interestingly, the population in Indonesia are predominantly intermediate acetylators [19]. Therefore, drug induced liver intoxication should be considered when giving positive IGRA individuals a long period of INH [20] and adherence as well as compliance, need to be well monitored. ...