Ignasi Carrió's research while affiliated with Autonomous University of Barcelona and other places
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Publications (372)
![Normal presynaptic dopaminergic PET Imaging. ① [¹¹C]-β-CFT. ②...](publication/374443024/figure/fig1/AS:11431281195872794@1696470599860/Normal-presynaptic-dopaminergic-PET-Imaging-C-b-CFT-F-FP-CIT_Q320.jpg)
![[¹⁸F]-FP-CIT PET in Parkinson’s disease (PD). ① Early stage of...](publication/374443024/figure/fig3/AS:11431281195842328@1696470600069/F-FP-CIT-PET-in-Parkinsons-disease-PD-Early-stage-of-disease-Late-stage-of_Q320.jpg)
![[¹⁸F]-FP-CIT PET in other neurodegenerative parkinsonism. ① Multiple...](publication/374443024/figure/fig4/AS:11431281195872795@1696470600178/F-FP-CIT-PET-in-other-neurodegenerative-parkinsonism-Multiple-system_Q320.jpg)
Presynaptic dopaminergic positron emission tomography (PET) imaging serves as an essential tool in diagnosing and differentiating patients with suspected parkinsonism, including idiopathic Parkinson’s disease (PD) and other neurodegenerative and non-neurodegenerative diseases. The PET tracers most commonly used at the present time mainly target dop...
Aim
We performed a systematic survey to assess the existing gaps in Europe in multidisciplinary education for integration of radioligand therapy (RLT) into cancer care and to obtain detailed information on the current limitations and key contents relevant.
Methods
A high-quality questionnaire, with emphasis on survey scales, formulation, and valid...
Radiotherapy or chemotherapy and new drugs and strategies in oncology can produce damage in normal organs and tissues affecting the quality of life of the patient. Pulmonary toxicity is frequently seen in patients treated with bleomycin or other chemotherapeutic agents. The most common clinical form of bleomycin pulmonary toxicity is the subacute c...
Alzheimer’s disease (AD) is the main cause of dementia, with its diagnosis and management remaining challenging. Amyloid positron emission tomography (PET) has become increasingly important in medical practice for patients with AD. To integrate and update previous guidelines in the field, a task group of experts of several disciplines from multiple...
Aim to assess if the use of an audiovisual intervention in the uptake room and/or in the scanning room, could help to reduce anxiety during [18F]FDG PET/CT imaging.
Methods We prospectively studied 120 patients referred for [18F]FDG PET/CT imaging. Patients were allocated in 4 groups of 30 patients depending on the use of the audiovisual interventi...
Although there is evidence that chemotherapy can have side effects on metabolism and brain function, there are few studies on the occurrence of these side effects with immunotherapy. The present study was conducted to assess whether brain metabolic changes occur in patients with malignant melanoma under immunotherapy. Thirty-nine patients after sur...
Purpose
Positron emission tomography (PET) with the first and only tau targeting radiotracer of ¹⁸ F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment. The goal of this international consensus is to help nuclear medicine practitioners procedurally per...
![Flowchart for a recommended approach for the use of [¹⁸F]-FDG PET/CT in...](publication/354192907/figure/fig1/AS:1062005939126277@1630213355029/Flowchart-for-a-recommended-approach-for-the-use-of-F-FDG-PET-CT-in-pediatric_Q320.jpg)
PurposePositron emission tomography (PET) with 18F-fluorodeoxyglucose ([18F]-FDG) has been increasingly applied in precise localization of epileptogenic focus in epilepsy patients, including pediatric patients. The aim of this international consensus is to provide the guideline and specific considerations for [18F]-FDG PET in pediatric patients aff...
Positron emission tomography (PET) is a functional imaging technique introduced in 1970s. Over the years, PET was used alone but is in 2000 when the first hybrid PET/CT device was clinically introduced. Since then, PET has continuously been marked by technological developments, being the most recent one the introduction of silicon photomultipliers...
Imaging of cancer has played an essential role in defining the local and regional extent of the disease. There is increasing recognition that it will have a crucial role in characterizing disease, the testing activity of novel therapies, and proper evaluation of therapeutic efficacy. Traditionally, treatment response evaluation in oncology is based...
Cardiac autonomic nervous system contributes to maintain haemodynamic and electrophysiological stability to changing demands. Cardiac innervation imaging can be performed by means of planar scintigraphy/SPECT or PET using different radiotracers developed for the assessment of pre- and postsynaptic receptors of the cardiac autonomic nervous system,...
The ESC Textbook of Cardiovascular Imaging third edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a ‘state of the art’ clinically ori...
Introduction:
Positron emission tomography (PET) amyloid quantification methods require magnetic resonance imaging (MRI) for spatial registration and a priori reference region to scale the images. Furthermore, different tracers have distinct thresholds for positivity. We propose the AMYQ index, a new measure of amyloid burden, to overcome these li...
This text atlas is a superb guide to the use of PET-CT for the evaluation of treatment response in oncology patients based on its ability to assess tumor metabolic status. The first part of the book explains the role of PET-CT in response evaluation in different treatment settings. For comparison, overviews of the value and limitations of CT alone,...
Aim:
To assess if digital PET/CT improves liver lesion detectability compared to analog PET/CT in patients with known or suspected liver metastases.
Materials and methods:
We prospectively included 83 cancer patients, with one or more of these conditions: history of liver metastases, clinical risk of having liver metastases or presence of suspec...
Background
Quantification of amyloid‐β (Aβ) PET images is a surrogate marker of amyloid deposition in the brain. MRI‐independent approaches have been developed and have reported accurate quantification without the use of MRI but they still require a reference region to compute a SUVr value. The goal of this work was to design a new measure of amylo...
In this report, several issues relevant to scientific publishing in the field of medical imaging are described. How the quality of the research in medical imaging is evaluated is presented as well. The need for journals and the role of current metrics to judge the quality of articles and journals are discussed. Several recommendations are given to...
Background
Impulse control disorders (ICD) are a common and disrupting complication of Parkinson’s disease (PD) treatment. Although their relationship with dopaminergic activity is well studied, their brain metabolic correlates are mostly unknown.
Methods
In this work we studied brain metabolism using brain ¹⁸F-FDG-PET. We performed a case-control...
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has placed significant challenges on health care systems worldwide, whether in the preparation, response, or recovery phase of the pandemic. This has been primarily managed by dramatically reducing in- and outpatient services for other diseases and implementing infection prevention and...
During the last decade, positron emission tomography/computed tomography (PET/CT) and single-photon emission computed tomography/computed tomography (SPECT/CT) have procured advances in research and clinical application of fusion imaging. The recent introduction of digital PET/CT opens new horizons for multimodality molecular imaging. This system o...
The correct administered activity of 18F-FCH is 0.1–0.14 mCi/Kg, which is equivalent to 3.7–5.2 MBq/kg.
Objective
To compare detectability of hyperfunctioning parathyroid tissue (HPT) by digital and analog 18F-fluorocholine PET/CT in patients with primary hyperparathyroidism and negative/inconclusive 99mTc-MIBI scintigraphy-SPECT/CT.
Materials and methods
Thirty-three patients with primary hyperparathyroidism and negative/inconclusive 99mTc-MIBI sci...
Purpose
The purpose of this study was to assess whether digital photon counting technology in digital PET/CT influences the quantification of SUVmax in target lesions and regions of reference compared to analog PET/CT before an interchangeable use of either system in follow up studies.
Methods
From January to June of 2018, 100 oncological patients...
Objective
The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients.
Materials and methods
One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January–June 2018. All patients, who accepted t...
Purpose
Huntington’s disease (HD) is a fatal neurodegenerative disorder with no effective treatment currently available. Although the pathological hallmark of HD is massive striatal atrophy, it has been suggested that cortical deterioration may concomitantly occur and play a major role in the patient’s functional independence. Our objective was to...
The article Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions, written by Francisco Fuentes-Ocampo, Diego Alfonso López-Mora, Albert Flotats, Gabriela Paillahueque
Introduction:
The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach.
Methods:
Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neurops...
Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, and nuclear medicine specialists convened at the Eur...
Aim: The aim of this study is to evaluate the physical performance of the Philips Vereos whole-body PET/CT system according to the NEMA NU2-2012 standard and to compare it to other state-of-the-art PET/CT systems. Methods: Spatial resolution, sensitivity, count-rate performance, count rate accuracy and image quality were assessed. Specifically, spa...
Objective:
Normalization to an appropriate reference region in F-FDG PET imaging may enhance diagnostic performance in Huntington disease (HD). We aimed to identify stable brain areas that could be used to model neurometabolic degeneration in HD correlating imaging (SUVrvalues at the basal ganglia [BBGG]) and clinical parameters (disease burden sc...
Introduction:
Bilingualism exerts neuroprotective effects against neurodegeneration. In Huntington's disease (HD), the systems involved in bilingual control show early compromise, but the effect of bilingualism on the course of HD is unknown.
Methods:
We addressed the impact of livelong use of bilingualism on the clinical features, brain structu...
Background
Apathy is the most prevalent and characteristic neuropsychiatric feature of Huntington's disease. Congruent with the main early pathological changes, apathy is primarily associated with subcortical damage in frontal‐striatal circuits. However, little is known about its precise subserving mechanisms and the contribution of regions other t...
Dementia with Lewy bodies (DLB) is the most common cause of dementia after Alzheimer disease. It is often underdiagnosed because of the overlapping with Alzheimer disease symptoms. We report the F-FDG and F-florbetapir dynamic PET images (early and delay phases) of an 83-year-old woman with cognitive impairment associated with visual hallucinations...
The intact heart is innervated by the parasympathetic and sympathetic fibers of the autonomic nervous system. Cardiac transplantation results in transection of the postganglionic neural axons innervating the heart. Axonal degeneration develops within days after transplantation and leads to total depletion of cardiac norepinephrine stores and eventu...
Radiotherapy or chemotherapy and new drugs and strategies in oncology can produce damage in normal organs and tissues affecting the quality of life of the patient. Pulmonary toxicity is frequently seen in patients treated with bleomycin or other chemotherapeutic agents. The most common clinical form of bleomycin pulmonary toxicity is the subacute c...
Purpose:
Radium Ra 223 dichloride (radium-223, Xofigo®) is the first targeted alpha therapy for patients with castration-resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach. We provide straightforward and practical recommen...
Aim
To study the usefulness of ¹⁸F-fluorocholine (FCH) in detecting the recurrence of primary brain tumors.
Materials and methods
A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumor. The distribution by pathology was: three grade ii astrocytomas, three g...
he new diagnostic criteria for Alzheimer's disease (AD) acknowledges the interest given to biomarkers to improve the specificity in subjects with dementia and to facilitate an early diagnosis of the pathophysiological process of AD in the prodromal or pre-dementia stage. The current availability of PET imaging biomarkers of synaptic dysfunction (PE...
Objectives
The proposal and implementation of a computational framework for the quantification of structural renal damage from 99mTc-dimercaptosuccinic acid (DMSA) scans.
The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independ...
PurposeTo investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T0) to post-onset conditions at 1 month (T1), 1-2 years (T2, T3). Methods
Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission tomography (G-SPECT) studies with...
Aim:
To study the usefulness of (18)F-fluorocholine (FCH) in detecting the recurrence of primary brain tumours.
Material and methods:
A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumour. The distribution by pathology was: three grade ii astrocytomas,...
Purpose
To assess metabolic changes in cerebral 18F-FDG PET/CT in premanifest and manifest Huntington’s disease (HD) subjects compared to a control group and to correlate 18F-FDG uptake patterns with different disease stages.
Materials and methods
Thirty-three gene-expanded carriers (Eight males; mean age: 43 y/o; CAG > 39) were prospectively inclu...
This study aimed to investigate in vivo dynamic metabolic changes after transplantation of induced pluripotent stem cells (iPSCs) and iPSC-derived enriched cardiomyocytes (iPSC-CMs) in a rat model of ischemic injury. Methods: Serial 18F-FDG PET, echocardiographic, immunohistochemical, and immunofluorescence studies were performed after transplantat...
Objectives:
The proposal and implementation of a computational framework for the quantification of structural renal damage from (99m)Tc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-inde...
This chapter summarizes the findings of a global survey aimed at assessing the strengths, weaknesses, opportunities, and threats (so-called SWOT analysis) of hybrid imaging (HI). Hybrid imaging comprises three imaging modalities: single-photon emission tomography (SPET)/computed tomography (CT), positron emission tomography (PET)/CT, and PET/magnet...
Alzheimer’s disease (AD) is the most common cause of dementia. Clinical diagnosis alone has only moderate accuracy and requires the presence of dementia. Amyloid-β (Aβ) imaging provides information and allows earlier diagnosis of AD and better differential diagnosis of dementia in vivo, showing significantly higher cortical Aβ burden in AD patients...
Rationale
123I-mIBG planar image heart-to-mediastinum ratios effectively risk-stratify heart failure (HF) patients. The value of single-photon emission computed tomographic (SPECT) imaging for identifying increased risk of ventricular arrhythmias is less clear. This study sought to determine if findings from simultaneous interpretation of 123I-mIBG...
Heart failure (HF) is associated with reduced cardiac sympathetic neuronal uptake of norepinephrine (NE), which can be assessed noninvasively using different radiotracers and planar or single-photon emission computed tomography (SPECT)/positron emission tomography (PET) imaging. Such sympathetic derangement in HF patients has shown to be an indicat...
Radiotherapy or chemotherapy and new drugs and strategies in oncology can produce damage in normal organs and tissues affecting the quality of life of the patient. Pulmonary toxicity is frequently seen in patients treated with bleomycin or other chemotherapeutic agents. The most common clinical form of bleomycin pulmonary toxicity is the subacute c...
In recent years, it has been clinically and neuropathologically revealed that some neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure (PAF) are overlapping diseases: Lewy body diseases (LBD) has thus become a general term for these diseases. In fact, Lewy bodies are pathologicall...
The new diagnostic criteria for Alzheimer's disease (AD) acknowledges the interest given to biomarkers to improve the specificity in subjects with dementia and to facilitate an early diagnosis of the pathophysiological process of AD in the prodromal or pre-dementia stage. The current availability of PET imaging biomarkers of synaptic dysfunction (P...
Objetivo: Las neoplasias de vejiga y tracto urinario presentan una alta tasa de recidiva. El TC abdominopélvico es la técnica estándar para su estudio de extensión. No está definido el papel del PET-TC, y si su empleo podría cambiar el manejo terapéutico. Material y métodos: Entre noviembre 2010-julio 2014 se estudiaron retrospectivamente a 33 paci...
Whole-body 3D PET/CT tumoral volume segmentation provides relevant diagnostic and prognostic information in clinical oncology and nuclear medicine. Carrying out this procedure manually by a medical expert is time consuming and suffers from inter- and intra-observer variabilities. In
this paper, a completely automatic approach to this task is presen...
Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, this new edition of The ESC Textbook of Cardiovascular Imaging provides extensive coverage of all cardiovascular imaging modalities, and is produced in collaboration with the European Association of Cardiovascular Imaging w...