Igael Madgar's research while affiliated with Tel Aviv University and other places

Publications (17)

Article
Infertility derived from mate etiology is a health problem which has increased over the last decades. Varicocele is a common cause for mate infertility with incidence of 35% and 75% among males with primary and secondary infertility, respectively, compared to 10%-15% among the general population. VaricoceLe is defined as dilated and entangled pampi...
Article
The increasing prevalence of cancer survivors who are infertile due to gonadal failure highlights the importance of fertility preservation prior to gonadotoxic treatments. Adolescent cancer patients may not be mature enough to produce sperm by masturbation, leading to the use of alternative methods for obtaining sperm for cryopreservation. The aim...
Article
To study the decision to have a child alone, the experience of gamete donation, the issue of disclosure of the donor link to the child, conception-related health and sociodemographic characteristics of the mothers, children's socioemotional development, and mother-child relationships. Qualitative study. Prior clients of a sperm bank. Eleven single...
Article
A case study involving four female patients inseminated with sperm samples from the same donor is reported. Routine amniocentesis of one of the patients revealed that the fetus is a carrier of a balanced reciprocal translocation, 46,XY,t(1;10)(q12;q11.2), which was subsequently detected in the donor. Counselled amniocentesis in the three remaining...
Article
Full-text available
Current recommendations regarding posthumous sperm retrieval (PSR) are based on a small number of cases. Our purpose was to determine the time interval from death to a successful procedure. Seventeen consecutive PSR procedures in 14 deceased and 3 neurologically brain-dead patients at two male infertility centres [Sheba Medical Center (SMC), Tel-Ha...
Article
To compare semen parameters and intracytoplasmic sperm injection (ICSI) outcome in spinal cord-injured subjects who underwent single (group 1) or multiple (group 2) electroejaculations before ICSI. Prospective, randomized, controlled study. Department of gynecology, obstetrics, and pediatric science in a reproductive medicine unit at a major Italia...
Article
To characterize clinical and laboratory findings in nonmosaic 47,XXY patients that may help to predict spermatogenetic activity in their testicles. Prospective study. Assisted reproductive technology program. Twenty patients with nonmosaic Klinefelter syndrome who underwent testicular sperm retrieval for IVF. The correlation between basal FSH, LH a...
Article
Varicocele is a well-known and highly prevalent medical problem in young obligatory service recruits. Still, there are many questions regarding its management. Is there a clear relation between varicocele and infertility? Can early varicocelectomy in young soldiers prevent future infertility? Is there a role for varicocelectomy in pain relief in ph...
Article
Objective: To prospectively evaluate the role of intratesticular vascular flow in modulating sperm function in men with obstructive and nonobstructive azoospermia. The correlation of testicular Doppler values with nitric oxide and testicular sperm extraction was further evaluated. Design: Prospective study. Setting: Assisted reproduction unit...
Article
Recent developments in infertility treatment, as well as medical and ethical concern to preserve the fertilizing ability of male subjects potentially at risk, led to the inception of a sperm cryobank in our medical center in 1996. Up to the end of the year 2000, 64 young men displaying higher semen values than generally required were accepted as do...
Article
Full-text available
In this study we describe the cloning of a human gene, encoding a protein that shares 90% identity and 93% similarity at the primary structure level, with the mouse Pim-2 gene. The gene was designated hPim-2. Structural features suggest that like the mouse Pim-2, hPim-2 is also a serine threonine kinase. At the RNA level, two hPim-2 transcripts wer...
Article
Full-text available
To evaluate IVF outcome after epididymal and testicular sperm retrieval in patients with obstructive or nonobstructive azoospermia. Retrospective clinical analysis. Public university-affiliated IVF unit. One hundred twenty-three azoospermic patients (178 cycles). Sixty-three patients (103 cycles) with obstructive azoospermia (group 1) underwent eit...
Article
Full-text available
In all, 58 couples suffering from infertility because of congenital bilateral absence of the vas deferens underwent a total of 67 combined microsurgical epididymal aspiration or testicular sperm extraction (TESE) and in-vitro fertilization (TVT) treatments. The oocytes recovered were inseminated by either the microdroplet IVF technique (n=20), subz...
Article
Congenital bilateral aplasia of the vas deferens (CBAVD) was suggested to be a mild form of cystic fibrosis (CF). Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in males with CBAVD revealed that in some males CBAVD is caused by two defective CFTR alleles. The genetic basis of CBAVD in the other males and it...

Citations

... Infertility is a health problem that has increased over the last decades. Varicocele is one of the main causes of male infertility with incidence rate of 35-75 and 10-15 % among infertile men and general population, respectively [1]. Varicocele is an abnormal dilation of the pampiniform venous plexus in the scrotum [2]. ...
... This requires coordination with operating room and laboratory staff. It is more often used in patients who have failed PVS and is considered next-line therapy [68]. It can often be performed in the same anesthetic setting as additionally required oncologic procedures with minimal morbidity [69]. ...
... PIM2 encodes a serine/threonine kinase that regulates cell proliferation signaling and is abundant in hemato-poietic tissues and the gastrointestinal tract. PIM2 is highly expressed in leukemia and colorectal cancer and has been associated with other cancers [19,20]. In addition, the PIM2 expression level was reportedly increased in the gastric mucosa of children with Helicobacter pylori infection and may be involved in gastric cancer [10]. ...
... qualitatively. In addition, some testis vascular parameters have been associated with sperm quality 98,99 or have been suggested to be useful in discriminating obstructive -and nonobstructive azoospermia [100][101][102][103] or residual spermatogenic areas in non-obstructive azoospermia 100 . However, at present, these have been investigated only for research purposes, with no impact on the clinical management of azoospermic men 1 . ...
... There is a paucity of studies that have systematically used GWAS data, with the focus specifically at the gene level, to investigate the effects of independent variants on complex mental traits. In classical Mendelian diseases, it is well known that different pathogenic variants within one gene can be implicated in the same or a highly similar disease: e.g., numerous mutations within CFTR can cause cystic fibrosis [16][17][18][19][20], while several mutations in the BRCA1 can increase the risk to develop breast cancer [21][22][23]. This phenomenon, called allelic heterogeneity, arises when different variants within a gene are independently associated with the same trait, usually because they all lead to similar pathogenic changes in protein function. ...
... Initially, intracytoplasmic sperm injection (ICSI) was performed in couples with repeated failed fertilization (Palermo et al., 1992), following standard in-vitro fertilization (IVF). It soon became clear that ICSI could also be used for couples in which the male partner has a limited number of spermatozoa in the ejaculate, or for epididymal or testicular spermatozoa (Madgar et al., 1996). Moreover, it is now clear that none of the conventional semen parameters has any influence on the results of ICSI from ejaculated spermatozoa, except when totally immotile spermatozoa are available for the microinjection procedure . ...
... In our study, the NOA group had more frozen embryos. Other studies reported a similar pregnancy rate in both groups14,[17][18][19][20][21] . Francisco et al reported that pregnancy rate was similar in both groups regardless of the surgical procedure used 20 . ...
... years, some studies reported different predictive factors among series published in Table1. First, in only one multi-center study of 103 KS patients(14) testicular volume seems be bigger 7,8ml +/-2,5 in case of SRR positive versus 5,6mL +/-1,2 if SRR was negative.Among hormonal parameters, two studies reported that FSH level was significantly lower in case of SRR positive: 31.2 versus 40 UI (15) and 28.41 versus 33.08(16). In two other studies SRR were improved when Total testosterone level was higher at11,19), SRR is better in KS patients adolescent (54%) or adult (51%) when LH is lower than 17. 5 associated to testosterone higher than 7,5nmol/L.Many studies have investigated the impact of age on sperm recovery and in table 2, we reported the studies showing a significant difference of age between SRR positive and SRR negative. ...
... Anestezinin ejakülatın kalitesini etkileyebileceğini de unutmamak gerekir. 19 5) Transrektal masaj yöntemi; non-invaziv sperma toplamak için alternatif yöntemlerden biridir. Aksesuar eklenti bezlerinin rektal stimülasyonu kullanılarak yapılır. ...
... Elles sont plus âgées que leurs homologues mariées dans les banques de sperme, bien qu'aujourd'hui beaucoup de femmes mariées repoussent, elles aussi, le temps de la maternité pour des raisons similaires. Soixante pour cent d'entre elles ont dépassé l'âge de 40 ans [9,10]. Ces femmes n'étaient pas toujours conscientes qu'en repoussant leur désir de maternité à un âge plus tardif, elles courraient le risque de ne plus pouvoir le réaliser. ...