Ian R. White’s research while affiliated with British Society for Cutaneous Allergy and other places

... 6 Sometimes positive tests to metabisulphite 1% in pet. that has been added to the European baseline series, 7 are incorrectly classified as irritant 2 and its relevance is not always easy to determine, 8 although often discovered if a thorough examination of possible sources (both occupational and non-occupational) is carried out. 2,3 Cinnamon (and its components cinnamal and/or cinnamic alcohol) are also causes of allergic contact cheilitis/stomatitis, for example, chewing gum as a frequent cause (see reference 9 for a review) and tea. 10 In patients with severe and/or treatment-resistant cheilitis, stomatitis, and aphthosis, 11 a comprehensive history, patch testing, avoidance of the suspected agents, and clearing of the lesions are necessary to establish the diagnosis. ...

Reference:

Allergic contact cheilitis/stomatitis due to beverages and food, an underreported diagnosis

... Although BIT is currently not allowed in cosmetic products under European Union (EU) legislation, it is extensively used in non-cosmetic products such as detergents, paints, adhesives and fillers [22][23][24][25]. The usage of BIT increased significantly from 1995 to 2018, both in total weight (tonnes) and the number of products registered within the Swedish Products Register [22]. ...

Reference:

Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise

... 14 A recent report described a patient who reacted to benzyl salicylate, ethylhexyl salicylate, and homosalate. 15 One case of recurrent dermatitis following oral exposure to aspirin (acetylsalicylic acid) in a patient with methyl salicylate contact allergy has been reported, though this has never been replicated. 16 Despite the fact that salicylates are derivatives of salicylic acid substituted at a specific site ( Figure 1), cross-reactivity with salicylic acid itself has not been previously described. ...

Reference:

Allergic contact dermatitis to salicylic acid: A case series of relevant sensitization

... These restrictions resulted in a substantial decrease in contact allergy to MI across Europe. The European Surveillance System on Contact Allergies' (ESSCA) data showed a decline from 7.6% in 2013-2014 to 4.4% in 2017-2018, and the Information Network of Departments of Dermatology (IVDK) reported a decrease from 5.4% to 3.2% during the same period [9]. However, the prevalence of contact allergy has continued to increase in the United States, where MI remains less regulated [9]. ...

Reference:

Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise

... Several authors are indeed more frequently reporting case reports of severe ACD in paediatric patients [37,38], which can be severely impactful on their quality of life. In fact, contact allergy to (meth)acrylates can influence future job choices (e.g., dentistry [39], beauty industry [22], manufacturing [1]), requiring strict avoidance of these compounds. Also, in patients allergic to 2-HEMA caution should be used towards medical devices, such as orthopaedic or dental prosthesis, even if not necessarily an acrylate implant causes local or systemic reactions [40]. ...

Reference:

The Italian Trend of Contact Allergy to 2‐Hydroxyethyl Methacrylate: Is the Current European Legislation Working?

... Although BIT is currently not allowed in cosmetic products under European Union (EU) legislation, it is extensively used in non-cosmetic products such as detergents, paints, adhesives and fillers [22][23][24][25]. The usage of BIT increased significantly from 1995 to 2018, both in total weight (tonnes) and the number of products registered within the Swedish Products Register [22]. ...

Reference:

Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise

... GB is an effective technique for handling diverse datasets and constructing powerful predictive models by integrating multiple weak learners. GB is capable of managing imbalanced datasets but is susceptible to overfitting 50 . In addition, the training time may be relatively long owing to the iterative training of multiple models. ...

Reference:

Exploring non-invasive biomarkers for pulmonary nodule detection based on salivary microbiomics and machine learning algorithms

... Since patients with linalool HPs contact allergy also had MCAs, genetic factors might play a role. 30 There are a few limitations in this retrospective study. According to the PT procedure, the patch test chambers that were changed from Finn chamber to Finn chamber aqua in January 2018 might affect the patch test reactions; however, reactions of most of the allergens should remain virtually the same, according to a published study. ...

Reference:

Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene

... Its use is still permitted in a multitude of products including, but not limited to, non-EU cosmetics, veterinary products such as dog shampoo, industrial and domestic cleaning detergents and washing up liquids, fabric softeners and water-based dyes, paints and glues. The introduction of legislation resulted in a significant decrease in the prevalence of contact allergy to MDBGN [42]. Mercader-García et al reported current relevance of positive patch test to MDBGN could be ascertained in only 0.87% of cases and that exposure, whilst still possible is much scarcer than previous. ...

Reference:

Updated Criteria to Include Contact Allergens in the European Baseline Series With Suggested Additions: Potential Additions and Deletions From the EBS

... 20,21 Continued testing of MDBGN may therefore be recommended in cases of high clinical suspicion. 22 This reinforces the need for individualized patient assessment in occupational dermatology since conventional diagnostic methods are not able to capture the complete allergen spectrum. 23 Although not explicitly mentioned for ACD, underreporting of occupational illnesses can be driven by a lack of awareness, fear of job loss, and inadequate workplace health surveillance, 24 leading many workers to ignore or self-treat minor symptoms. ...

Reference:

Challenges in diagnosing occupational allergic contact dermatitis: a case report