I. Opitz’s research while affiliated with Hospital for Special Surgery and other places

... In the context of targeted therapies and immunotherapy, the role of personalized medicine has become increasingly attractive in the management of NSCLC. Comprehensive genomic profiling allows the identification of key mutations that could guide treatment decisions, ensuring that patients receive the most effective therapies tailored to their specific tumor characteristics [108]. Moreover, the regulation and modification of specific intracellular procedures, like autophagy [109] or ferroptosis [110], may play a crucial role to battle NSCLC. ...

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Oncogenic Mutations and the Tumor Microenvironment: Drivers of Non-Small Cell Lung Cancer Progression

... This definition assumed that patients were medically operable, that all types of major pulmonary resection could be considered, and that resectability had to be assessed upfront before any treatment. This comprehensive project included a systematic review [28], a survey [29], and clinical case discussions [30]. ...

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What Does N2 Lymph Node Involvement Mean for Patients with Non-Small Cell Lung Cancer (NSCLC)?—A Review of Implications for Diagnosis and Treatment

... In this scenario of new potentially curative perioperative approaches, it is also to be considered that consensus on resectability of lung cancer is changing, and during 2023 WCLC, new perspectives about resectability were presented. In patients with N2 multistation, some T4 tumors, by infiltration of major structures and N2 bulky (only in highly selected cases), are to be considered potentially resectable, needing a multidisciplinary approach with caseby-case discussion, involving a range of specialists, including thoracic surgeons, radiation oncologists, oncologists or pulmonologists, pathologists, and imaging specialists [113,114]. Nowadays, molecular characterization plays a relevant role in therapeutic choices, even in the early setting of NSCLC. Indeed, we know how some gene alterations (i.e., EGFR, ALK, ROS1, and RET) can reduce the probability of response to immunotherapy regardless of PD-L1 expression. ...

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Immune Checkpoint Inhibitors and Targeted Therapies in Early-Stage Non-Small-Cell Lung Cancer: State-of-the-Art and Future Perspectives

... This definition assumed that patients were medically operable, that all types of major pulmonary resection could be considered, and that resectability had to be assessed upfront before any treatment. This comprehensive project included a systematic review [28], a survey [29], and clinical case discussions [30]. ...

Reference:

What Does N2 Lymph Node Involvement Mean for Patients with Non-Small Cell Lung Cancer (NSCLC)?—A Review of Implications for Diagnosis and Treatment

... This is particularly interesting in the setting of an increasing body of evidence to support this approach, [20][21][22][23][24] with surgical guidelines in preparation, but a preponderance of multidisciplinary trials focusing on radiation for local consolidation. [25] More than 3 times as many surgeon respondents would choose resection rather than radiation in this setting. This is particularly notable given the surgeons' familiarity with the nuances of these types of operative procedures. ...

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Surgeon preferences for self-treatment in locally advanced non–small cell lung cancer: Would we practice what we preach?

... Lung tumor remains the leading cause of tumor death rate, with the estimation of 1.80 million deaths (18%), and the global tumor burden was expected as around 28.40 million cases in 2040 and also rises 48% in 2020, which was a huge increase in transitioning (from 65% to 94%) versus transitioned (33% to 57%) countries due to the cause of demographic change, although this will be further exacerbated by increasing in risk factor which is associated with globalization and for an economical growth [3]. There are standard challenges on recognizing the lung tumors on patients from a decade like zero symptoms irrelevant to age factor, patients suffering from breathing problem, and patients affected with 30-40 years of smoking, which are very critical to identify in their early stages [4,5]. In addition, inconsistent treatment and monitoring raise the risk of death. ...

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Cloud-Based Lung Tumor Detection and Stage Classification Using Deep Learning Techniques

... After 3 months of treatment, the same group of surgeons conducted a comprehensive evaluation of clinical efficacy in accordance with the World Health Organization's Response Evaluation Criteria in Solid Tumors (WHO RE-CIST) [7]. The assessment categorized outcomes into four distinct classifications: complete remission (CR) (all target lesions disappeared), partial response (PR) (reduction in the sum of target lesion diameters by a minimum of 30% from baseline measurements), stable disease (SD) (reduction in target lesion size insufficient to qualify as PR or increase insufficient to qualify as progressive disease; representing an intermediate state between PR and PD), and progressive disease (PD) (increase in the sum of target lesion diameters by at least 20% from baseline measurements). ...

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Effect of Anatomical Pulmonary Segmentectomy and Lobectomy under Uniportal Video-Assisted Thoracoscopic Surgery on Cardiopulmonary Function and Serum Tumor Markers in Patients with Early-Stage Non-Small Cell Lung Cancer

... 12 In the consensus report published after the survey in which expert opinions were obtained using the Delphi method, it was reported that 87% of participants defined PAL as air drainage over 5 days. 13 With common acceptance in literature, PAL was defined as air drainage lasting longer than 5 days. ET was accepted as the postoperative day when the remaining lung was fully expanded in routine postoperative radiologic follow-up. ...

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Analysis of Factors Affecting Prolonged Air Leak and Expansion Failure in the Lung after Resection in Patients with Pulmonary Malignancy and Predictive Value of Preoperative Quantitative Chest Computed Tomography

... [11] In a survey conducted by the European Society of Thoracic Surgeons (ESTS) and the European Association of Cardio-Thoracic Surgery (EACTS) to assess the impact of gender discrimination on cardiothoracic surgical careers, 67% of the female participants were treated unfairly due to gender discrimination, whereas this rate was only 2.5% among male participants. [15] In our study, more than half of the participants (57.5%) were dissatisfied with their place in their professional lives. In addition, 64.4% of them were subjected to mobbing, as they were women in their professional lives. ...

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Evaluation of gender bias in thoracic surgery in Türkiye: A descriptive study

... Moreover, advanced age is often associated with diminished cardiopulmonary reserve and compensatory abilities, as well as attenuated cardiovascular stress response, rendering them relatively intolerant to surgical trauma and anesthesia (Tohidinezhad et al. 2022). Consequently, the increase in age is correlated with postoperative conduction system dysfunction, thereby elevating the risk of inducing arrhythmias (Benker et al. 2022). These insights underscore the critical importance of preventative measures and early intervention for postoperative arrhythmias in elderly lung cancer patients, aiming to enhance their prognosis and quality of life. ...

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Postoperative arrhythmias in geriatric lung cancer patients undergoing thoracoscopic surgery: an exploration of prevalence and influencing factors