I. A. Kosenko's research while affiliated with N.N. Alexandrov National Cancer Centre and other places

Publications (15)

Conference Paper
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Цель: оценить совместное влияние лазерных технологий (внутривенное лазерное облучение крови (ВЛОК) и системная фотодинамическая терапия (cФДТ) в комбинации с контактной лучевой терапией (КЛТ) на показатели роста экспериментальных опухолей in vivo. Материал и методы: Исследование выполнено на 130 лабораторных животных: 80 крыс с саркомой-45 (Са-45)...
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INTRODUCTION The prognosis of patients with persistent or recurrent cervical cancer (CC) is poor, and patient selection for exenterative surgery is challenging. The aim of this study was to determine the outcomes of patients undergoing pelvic exenteration (PE) for persistent or recurrent CC after treatment with radiotherapy in Belarus. METHODS A re...
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Background. Malignant tumors management using conventional treatment modalities is associated with poor outcomes. Objective of the study. To assess photodynamic activity of Photolon as monotherapy, as well as in combination with radio- and chemotherapy in an experiment. Material and methods. The research was done on HeLa monolayer culture (human u...
Conference Paper
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Objective To study the efficacy of neoadjuvant chemotherapy (NACT) with uterine artery chemoembolization (UACE) followed by radical surgery or radiotherapy in patients with locally advanced cervical cancer (LACC). Methods Study included 55 primary LACC patients: 25 presented stage IIB (45.5%), 28 – IIIB (50.9%) and 2 – IVA (3.6%). Forty-seven pati...
Conference Paper
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Цель: Разработать новый вариант модификации лучевого лечения нерезектабельного рака шейки матки (НРШМ), который позволит повысить излеченность опухоли и снизить степень побочного действия специального лечения. Материалы и методы: В экспериментах in vitro и in vivo изучены медико-биологические свойства фотолона, а также противоопухолевая активность...
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Introduction. The state of pelvic and retroperitoneal lymph nodes is an important prognostic factor for cervical cancer. Lymph node size is the most widely used CT and MR criteria for assessing lymph node status. Lymph nodes measuring more than 1cm in the short axis diameter are considered malignant. However this criterion (nodal size) is not foolp...
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A new multimodality approach has been developed for management of locally advanced cervical cancer, including neoadjuvant chemotherapy with chemoembolization of two uterine arteries, a subsequent brachytherapy treatment at a dose of 10 Gy and type III hysterectomy or pelvic exenteration; this approach has made it possible to attain tumor resectabil...
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Aim. To evaluate the prognostic significance of immunohistochemical expression profile of some antigens in patients with cancer of the cervix. Methods. Analysed was the data of primary medical records (medical history and hospital records) and information of the Belarusian Cancer Registry of the 100 women who received special treatment in the Repub...
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Due to the poor outcomes of treatment for locally advanced cervix uteri cancer (CUC), new multimodality treatment modes have been recently sought for this patient population, by using neoadjuvant multidrug chemotherapy (MDCT) prior to surgical intervention. Many investigators are inclined to consider this approach to be an alternative to the standa...
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Five-year overall and recurrence-free survival was evaluated in 84 stage I endometrial cancer patients with such histological patterns as poorly differentiated endometrioid adenocarcinoma, clear-cell carcinoma, serous papillary cancer, poorly differentiated cancer and mixed-type carcinoma. Overall 5-year survival in the whole group was 60.1 +/- 5.9...