Hyun-Kyung Song's research while affiliated with Korea Institute of Oriental Medicine and other places

Publications (24)

Article
Veronica persica is a flowering plant belonging to the family Scrophulariaceae. Here, we aimed to evaluate the pharmacological activity of the ethanol extract of Veronica persica (EEVP) in an airway inflammation model. We examined airway responsiveness to aerosolized methacholine, serum immunoglobulin (Ig)E levels, and total cell numbers in the lun...
Article
Background : Terminalia chebula (TC) is a traditional medicinal plant used for treating various diseases in humans. However, pharmacological mechanisms underlying the effects of TC in atopic treatment remain unelucidated. Hypothesis/Purpose : We investigated the therapeutic effects of TC extract in a mouse model of atopic dermatitis (AD) in vivo a...
Article
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S. patholobus suberectus Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic dermatitis (AD) has not been investigated. In this study, we explored the effect of S. suberectus Dunn water extract (SSWex) on AD...
Article
Alpinia officinarum (AO) has been traditionally used in Asia as an herbal medicine to treat inflammatory and internal diseases. However, the therapeutic effect of AO on atopic dermatitis (AD) is unclear. Therefore, we examined whether Alpinia officinarum water extract (AOWex) affects AD in vivo and in vitro. Oral administration of AOWex to NC/Nga m...
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Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion and metastasis. Matriptase is highly expressed in breast cancer and is associated with poor patient outcome. However, the cellular mechanism by which matriptase mediates breast cancer invasion remains unknown. T...
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Periodontitis is a Gram-negative bacterial infectious disease. Numerous inflammatory cytokines, including interleukin-1β (IL-1β), regulate periodontitis pathophysiology and cause periodontal tissue destruction. In human gingival fibroblasts (HGFs), IL-1β stimulates the production of matrix metalloproteinases (MMPs) and proinflammatory cytokines via...
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Bruton's agammaglobulinemia tyrosine kinase (BTK) is an important cytoplasmic tyrosine kinase involved in B‑lymphocyte development, differentiation, and signaling. Activated protein kinase C (PKC), in turn, induces the activation of mitogen‑activated protein kinase (MAPK) signaling, which promotes cell proliferation, viability, apoptosis, and metas...
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Atopic dermatitis (AD) is a skin allergy accompanied by acute and chronic dermal inflammation. In traditional oriental medicine, Laminaria japonica has been used to treat various diseases, including inflammatory diseases. Therefore, to determine the therapeutic potential of L. japonica against AD, we investigated the inhibitory effects of L. japoni...
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Background: Platycodon grandiflorum is a flowering plant that is used in traditional medicine for treating pulmonary and respiratory disorders. It exerts various pharmacological effects, including immunomodulatory and anti-cancer activities. The purpose of this study was to confirm the in vitro and in vivo immune-enhancing effects of P. grandiflor...
Article
Objective: Periodontitis is an inflammatory disease of the supporting tissue around teeth commonly caused by gram-negative bacterial infections. Interleukin (IL)-1β, a cytokine involved in host immune and inflammatory responses, is known to induce the activation of various intracellular signaling pathways. One of these signaling mechanisms involve...
Article
Casein kinase 2 (CK2) is a serine/threonine protein kinase that has been considered to represent an important factor in mammary tumorigenesis. Increased expression of matrix metalloproteinase‑9 (MMP‑9) via nuclear factor‑κB (NF‑κB) activation has been demonstrated to promote breast cancer cell invasion. In the present study, the involvement of CK2...
Article
UVB has been shown to stimulate the generation of ROS, which subsequently results in activation of various intracellular signaling pathways and transcription factors (AP-1, NF-κB), These transcription factors are regulated by MAPKs, which increase cytokine and MMP expression. We examined the preventive effects of reversine on MMP-1 and -3 expressio...
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Purpose Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion. Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia....
Data
CFE inhibits TPA-induced Migration in MCF-7 cells. (A) Cells were treated with various concentrations of CFE for each time. Cells were detected by EZ-cytox viability assay kit. (B) Cells were seeded in the upper chamber of chamber dishes and were either treated with CFE or untreated. After 24 hours, invasion cells were counted after staining.
Data
CFE inhibits migration and Matrigel invasion in MDA-MB-231 cells. (A) CFE were treated with indicated concentrations for 24 hours and then assayed using with EZ-cytox cell viability assay kit. To confirm the (B) migration, and (C) Matrigel invasion in MDA-MB-231 cells, cells were seeded in the upper chamber of chamber dishes and were treated with C...
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Cancer cell invasion is crucial for metastasis. A major factor in the capacity of cancer cell invasion is the activation of matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix. Salvia miltiorrhiza has been used as a promotion for blood circulation to remove blood stasis. Numerous previous studies have demonstrated that S. mi...
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The biological function of NADPH oxidase (NOX) is the generation of reactive oxygen species (ROS). ROS, primarily arising from oxidative cell metabolism, play a major role in both chronological ageing and photoageing. ROS in extrinsic and intrinsic skin ageing may be assumed to induce the expression of matrix metalloproteinases. NADPH oxidase is cl...
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The constituents of Peucedanum japonicum Thunb. (PJ) exhibit biological and pharmacological activities, including anti-obesity, anti-oxidant and anti-allergic activities. The aim of the present study was to esxamine in vitro effects of PJ in RANKL-induced signaling pathways, which determine osteoclast differentiation. PJ ethanol extract (PEE) exhib...
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Background Sophorae Flos (SF) is a composite of flowers and buds of Styphnolobium japonicum (L.) Schott and has been used in traditional Korean and Chinese medicine for the treatment of hemostasis and inflammation. Previous studies reported that SF possesses anti-obesity properties, as well as anti-allergic, anti-proliferative, and anti-inflammator...
Article
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Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidyli...
Data
Supplementary figure 1: NADPH oxidase activity increases in aged HDFs. Supplementary figure 2: The expression of PIP3 increases with increasing PD of HDFs. Supplementary figure 3: Increased PIP3 levels inhibited through suppression of PI3K in aged HDFs. Supplementary figure 4: Inactivation of PTEN increases PIP3 expression. Supplementary figure 5:...
Article
Full-text available
Metastatic cancers spread from their site of origin (the primary site) to other parts of the body. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is important in metastatic cancers as it plays a major role in cancer cell invasion. The present study examined the inhibitory effect of an ethanol extract of Peucedanum japo...
Article
Invasion and metastasis are among the main causes of death in patients with malignant tumors. Fisetin (3,3',4',7-tetrahydroxyflavone), a natural flavonoid found in the smoke tree (Cotinus coggygria), is known to have antimetastatic effects on prostate and lung cancers; however, the effect of fisetin on breast cancer metastasis is unknown. The aim o...

Citations

... IgE binds to the IgE receptor attached to the surface of mast cells, and activates mast cells to release various pro-inflammatory cytokines, histamines, and chemokines [11][12][13]. Keratinocytes are cells that play an important role in skin diseases, and they stimulate epidermal keratinocytes with pro-inflammatory cytokines such as TNF-α/IFN-γ to produce inflammatory chemokines [14]. In addition, activation of inflammatory signaling pathways such as MAPK/NF-κB induce the synthesis of inflammatory chemokines, leading to skin inflammation [15]. ...
... BTK inhibitors [ibrutinib , CNX-774] significantly attenuated TPA-induced cell invasion and migration in MCF-7 cells and inhibited the activation of the phospholipase Cγ2/PKCβ signaling pathways BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) and is essential both for B cell development and function of mature [35,36]. ...
... In the present study, Nc/Nga mice aged 7-8 weeks were maintained on a high-fat diet exacerbates the development of AD-like symptoms (Jena et al., 2019). However, they were too young to show severe AD symptoms, which were developed after DNCB treatment of the dorsal skin (Hwang et al., 2020;Jeong et al., 2020). Jena et al. (2019) reported that long-term intake of high-fat diets, corresponding to Westernstyle diets, results in dermatitis by activating Th2 and Th17 cells in C57BL/6 mice. ...
... However, the non-selective toxicity of Cy renders it toxic to normal cells, thereby causing bone marrow failure, which exacerbates anemia symptoms along with thrombocytopenia, and physiological phenomena, such as poor body growth and decreased immune function (26,27). Thus, there is an increasing demand to identify and develop bioactive substances capable of lowering the side effects and toxicity of immunosuppressive drugs with non-selective toxicity (28)(29)(30). ...
... Therefore, the early detection of these biomarkers can objectively reflect the disease state for early diagnosis and treatment. For instance, inflammatory factors, such as interleukin (IL)-1β, IL-6, and MMP-8, can reflect the occurrence and development of periodontitis 27 . In the proteomic profile of oral cancer patients, elevation is observed in several biomarkers, including CYFRA-21-1, tissue polypeptide antigen, catalase, telomerase, α-amylase, albumin, glutathione, and proinflammatory factors. ...
... It was also demonstrated that emodin (5-200 µM) repressed MMP-2 and MMP-9 expression to restrain the migration and invasion of HCC MHCC-97H cells, by activating p38MAPK signal and inhibiting ERK/MAPK and PI3K/AKT signals [133]. Furthermore, as a CK2 inhibitor, emodin (20 µM) was revealed to suppress protein kinase C-induced tumor cell invasion through restraining CK2 activation and subsequently decreasing MMP-9 expression in breast cancer cells (MCF-7) [134]. ...
... The detected reduction of Nrf-2, the master regulator of antioxidant genes, augmented the oxidative damage. ROS increase the cellular membrane phosphorylation, thereby activate signaling pathway leading to increased MMP-1, MMP-3 secretion, and collagen degradation (Karin 1995;Kim et al. 2018). Indeed, we detected a marked increase in MMP-1 after UVA-exposure, reflected clinically as an elevated photoaging macroscopic score and markedly prolonged pinch test time in the vehicle-treated UVA-exposed mice. ...
... [39][40][41] Crotonis fructus, another important component of QX, was reported to inhibit 12-O-tetradecanoylphorbol-13-acetate-induced cell invasion and upregulate matrix metalloproteinase-9 expression in MCF-7 cells via protein kinase C/p38/c-Jun N-terminal kinase/AP-1 pathway. 42 Another herb in QX, Coptis chinensis, was shown to exert an anticancer effect by inhibiting the proliferation of vascular smooth muscle cells. 43 In addition to its direct antitumor effect, Coptis chinensis also has shown anti-inflammatory effects in mouse models by downregulating nitric oxide and inducible nitric oxide synthase via its suppression of NF-κB and MAPK activation. ...
... It is reported to have many biological activities, including antioxidant, antihypertensive, antidiabetic, anti-atherosclerotic, antibacterial, antifungal, and anticarcinogenic. Diallyl trisulfide (DATS), the most effective active ingredient found in garlic, has been shown to have antioxidant properties, the ability to reduce DNA double-strand breaks and induce cell cycle arrest and apoptosis (19)(20)(21)(22)(23)(24)(25)(26). DATS is a secondary metabolite of allicin; an organosulfur compound produced from the crushing of Allium sativum (garlic) (27). ...
... Они участвуют в процессах ремоделирования тканей и развития органов, специфически модулируя сигнальные пути посредством взаимодействия c субстратами разной природы, включая перестройки ВКМ (Nagase, Woessner, 1999;Page-McCaw et al., 2007, Kessenbrock et al., 2010. ЦИТОЛОГИЯ том 62 № 11 2020 БОБКОВ, ПОЛЯНСКАЯ Есть ряд работ, свидетельствующих об активном участии ММП и ВКМ в процессе старения разных клеточных типов (Moon et al., 2004;Vigetti et al., 2006;Bertram, Hass, 2009;Pitiyage et al., 2011;Makpol et al., 2013;Malaquin et al., 2013;Lynch, Pei., 2014;Gutierrez-Fernandez et al., 2015;Noh et al., 2017). Представленные исследования носят разрозненный характер, поскольку пока только накапливаются данные по анализу участия разных ММП в РС разных клеточных линий. ...