Hwan Seok Park's research while affiliated with Seoul Medical Center and other places
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Publications (5)
Background and Objective Restless legs syndrome induces sleep fragmentation and impairs sleep quality. Although insomnia is the most frequently reported symptom, a substantial proportion of patients report excessive daytime sleepiness (EDS), and the factors that contribute to EDS need to be assessed for optimal treatment. Methods Sixty-five untreat...
Ictal single-photon emission computerized tomography (SPECT) is often nonlocalized in patients with partial epilepsy. We repeated ictal SPECT in patients with partial epilepsy whose first ictal SPECT was nonlocalized. We also performed subtraction ictal SPECT coregistered to magnetic resonance imaging (MRI) (SISCOM) to test the localizability of ic...
Ictal Single Proton Emission Computed Tomography (SPECT) has demonstrated high levels of sensitivity in localizing seizures among patients with epilepsy of the mesial temporal lobe (mTLE). However, incorrect information on the lateralization of mTLE has also been reported. In order to investigate the causes of these incorrect localizations, the aut...
To investigate differences in brain gray matter concentrations or volumes in patients with obstructive sleep apnea syndrome (OSA) and healthy volunteers.
Optimized voxel-based morphometry, an automated processing technique for MRI, was used to characterize structural differences in gray matter in newly diagnosed male patients.
University hospital....
Sleep onset insomnia, defined as difficulty initiating asleep, is a common disorder with associated impairment or significant distress and is associated with daytime consequences. Although these sleep onset insomnia has generally been attributed to psychological or psychiatric causes, it can also be secondary to a medical, circardian, or sleep diso...
Citations
... Previous studies have demonstrated that delay in injection timing is one of the primary reasons for failure of SPECT to localise the EZ. 9,11,24,25 Previous studies have demonstrated that injection times of less than 60 seconds from seizure onset are sufficient for ictal hyperperfusion to be captured in the EZ, 9,11 while other studies suggest EZ localisation is improved when injection occurs within 30 seconds of the seizure onset. 11,12 Of note 76.9% (N=103) and 59.7% (N=80) of 'injectable seizures' in our cohort were injected within 60 and 30 seconds respectively. ...
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... Sleep disorders reportedly lead to dysfunction of the prefrontal cortex; the main symptoms of patients with OSA are sleep disorders (such as sleep interruption and abnormal rhythm) and intermittent hypoxemia, which may jointly lead to nerve cell damage in the prefrontal cortex [58]. In addition, a voxel-based morphometry study found that gray matter atrophy of the bilateral amygdala-hippocampal gyrus and bilateral SFG may be the cause of executive function impairment in patients with severe OSA [59]. Several studies showed that OSA could lead to functional and structural damage of the frontal lobe [60][61][62], which may explain the related working memory, executive function, and emotional disorders [63]. ...
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... SISCOM demonstrates regional differences in cerebral blood flow based on a differential between ictal and interictal perfusion imaging, and has been shown to improve the accuracy of epileptic focus localization [21,29,28,27,38]. Several studies in adults with TLE have shown that ipsilateral ictal SPECT hyperperfusion, the most common finding seen in one third of the patients, was a hallmark for lateralization of the epileptogenic temporal lobe and was associated with favorable surgical outcome [22,11,39,32,17,16,45,18]. In addition, other patterns including bilateral temporal, contralateral temporal, and extratemporal perfusion were also observed with various postoperative outcome correlation [16,8,45,38,4,7]. Despite frequent utilization of SISCOM in children, hyperperfusion patterns have not been well investigated in this population. ...
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